A5045826587- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Gut microbiota and health
- Peptidase Inhibition and Analysis
- Virus-based gene therapy research
- Herpesvirus Infections and Treatments
- Molecular Biology Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Histone Deacetylase Inhibitors Research
- HIV Research and Treatment
- Advanced biosensing and bioanalysis techniques
- Ovarian cancer diagnosis and treatment
- Telomeres, Telomerase, and Senescence
- Genetic factors in colorectal cancer
- Immune Response and Inflammation
- Cancer Genomics and Diagnostics
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- FOXO transcription factor regulation
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Leptospirosis research and findings
- Saffron Plant Research Studies
- Cell Adhesion Molecules Research
- Kruppel-like factors research
Aristotle University of Thessaloniki
2014-2025
Faculty of Public Health
2015
Laboratoire de Biochimie
2006-2015
National and Kapodistrian University of Athens
2001-2004
Mount Sinai Hospital
1995-2000
Cyprus Institute of Neurology and Genetics
2000
University of Toronto
1996-1998
Abstract We have developed 2 new quantitative methods for measuring anti‐p53 antibodies in human serum. Using these we analyzed 1,392 sera from patients with various malignancies and 230 individuals without malignancy. Highest prevalence of was associated ovarian colon cancers (15%), followed by lung (8%) breast (5%) cancers. Prevalence other lower (<4%). In hospitalized apparently healthy individuals, very low (<2 1% respectively). Extremely high antibody concentrations (> 10 5...
The objective of this study was to examine the impact polymorphisms in acyl-CoA:diacylglycerol acyltransferase (DGAT1), leptin and growth hormone receptor genes on body energy (body condition score, total content cumulative effective balance) blood metabolic traits (levels beta-hydroxybutyrate, glucose non-esterified fatty acids), measured once before first calving then repeatedly throughout lactation 497 Holstein cows. influence same cow reproductive performance health during second...
Human studies and clues from animal models have provided important links between gastrointestinal (GI) tract bacteria colon cancer. Gut microbiota antigenic stimuli play an role in shaping the intestinal immune responses. Therefore, especially case of inflammation-associated cancer, gut antigens may affect tumorigenesis. The present study aimed to investigate effects oral administration a bacterial product with known immunomodulatory properties on inflammation-driven colorectal...
p53Aberrations are frequent in colorectal carcinogenesis (40–70%). Because p53 gene mutations typically result increased protein concentration tumor cells, this cellular might become immunogenic during development. To test hypothesis, serum antibodies were quantitatively analyzed 229 patients with cancer, using an immunofluorometric procedure. Circulating against found 23% (53/229) of the patients. We quantified antibody concentrations all positive sera and that they varied from 300 to...
Genetic alterations of the p53 tumor suppressor protein are most frequent molecular events in human carcinogenesis. For as yet unknown reasons, mutant often acts an immunogen for autoantibody generation. These autoantibodies can be detected serum cancer patients. The presence such antibodies has been identified a subset patients with ovarian carcinoma, but their clinical significance not investigated.Serum samples from carcinoma were quantitatively analyzed time-resolved immunofluorometric...
Diabetes is regarded as an epidemiological threat for the twenty-first century. Phytochemicals with known pharmaceutical properties have gained interest in field of alleviating secondary complications diseases. Such a substance crocin, basic constituent saffron (Crocus sativus). The present study aimed at examining beneficial effects per os crocin administration on antioxidant status, blood biochemical profile, hepatic gene expression and plasminogen activator inhibitor-1 activity (PAI-1)...
To investigate the prevalence of Leishmania infection in rodents from various areas northern Greece.Ninety-seven (66 Mus musculus, 19 Rattus norvegicus and 12 R. rattus) were collected during pest control programmes examined by cytology (spleen liver smears), serology (ELISA) PCR (real-time gel-based) for Leishmania. Date, environment, sex, existence dogs close environment recorded each rodent.All cytological preparations negative, whereas specific IgG was detected 54.5% total; 70%...
Background: Hepatocellular carcinoma (HCC) is a frequently diagnosed cancer and leading cause of cancer-related death worldwide. Its rapid progression, combined with the limited treatment options at late stages, imposes need for early detection aggressive intervention. Based on knowledge that hepatocarcinogenesis significantly influenced by histone acetylation, we directed our search novel HCC therapeutics among deacetylation inhibitors (HDACi). The aim present study was to investigate...
Urokinase-type plasminogen activator (uPA) participates in cancer-related biologic processes, such as wound healing and inflammation. The present study aimed to investigate the effect of uPA deficiency on long-term outcome early life episodes dextran sodium sulfate (DSS)-induced colitis mice. Wild-type (WT) uPA-deficient (uPA(-/-)) BALB/c mice were treated with DSS or remained untreated. Mice necropsied either 1 week 7 months after treatment. Colon samples analyzed by histopathology,...
The suppression of the bone morphogenetic protein (BMP) signaling pathway has been recently shown to promote adenoma-to-carcinoma transition in sporadic colon cancer. However, its role evolution early preneoplastic changes neoplasia remains elusive. In present study, we aimed investigate gene expression levels multiple extracellular BMP family constituents, including ligands/receptors and inhibitors, during stages inflammation-associated carcinogenesis. For that, used developed...
Several hereditary disorders, particularly those affecting the physiological anticoagulation systems, have been well established as risk factors for venous thromboembolism. In present study, we investigated prevalence of following thrombogenic mutations in a Greek-Cypriot population: G1691 factor V Leiden mutation, G20210A mutation prothrombin gene, and C677T methylenetetrahydrofolate reductase (MTHFR). All three variants documented to be significant various cardiovascular conditions. Ninety...
Inflammation-associated oxidative stress contributes to hepatic ischemia/reperfusion injury (IRI). Detrimental inflammatory event cascades largely depend on activated Kupffer cells (KCs) and neutrophils, as well proinflammatory cytokines, including tumor necrosis factor α (TNF-α) interleukin (IL) 18. The aim of our study was evaluate the effects IL 18 binding protein (IL 18Bp) in IRI mice. Thirty C57BL/6 mice were allocated into 3 groups: sham operation, (I/R), I/R with intravenous...
The presence of prostate-specific antigen (PSA) protein and messenger RNA (mRNA) was studied in 52 primary lung tumor tissues. PSA detected more frequently at higher levels extracts from men. correlated with preoperative postoperative serum levels, suggesting a possible contamination the residual blood vasculature. mRNA by reverse transcription-polymerase chain reaction (RT-PCR) Southern blot hybridization 24 (68%) 35 tumors men, 9 (53%) 17 women, 5 (71%) 7 adjacent normal tissue specimens....