A5061115492- Polysaccharides and Plant Cell Walls
- Herbal Medicine Research Studies
- Pain Mechanisms and Treatments
- Complementary and Alternative Medicine Studies
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Polysaccharides Composition and Applications
- Microbial Metabolites in Food Biotechnology
- Fungal Biology and Applications
- Phytochemistry and Biological Activities
- Exercise and Physiological Responses
- Natural Compound Pharmacology Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Food composition and properties
- Phytochemistry and Bioactive Compounds
- Sulfur Compounds in Biology
- Cannabis and Cannabinoid Research
- Helicobacter pylori-related gastroenterology studies
- Bartonella species infections research
- Tea Polyphenols and Effects
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Alcohol Consumption and Health Effects
- Anesthesia and Pain Management
- Gout, Hyperuricemia, Uric Acid
Universidade de São Paulo
2020-2024
Universidade Federal do Paraná
2017-2023
Chamomile is one of the most ancient medicinal herbs known to mankind and among its traditional uses are calming effects. However, few studies explored effects on central nervous system (CNS). In this study we further proceed with structural elucidation polysaccharides from chamomile tea. A highly substituted 4-O-methyl-glucuronoxylan (fraction SN-50R) was purified chemically characterized, presenting Xyl:GlcA ratio 1.7:1, Mw 500 kDa total sugar content 98%. Its bioactivity pain CNS...
A β-D-glucan was obtained from the edible mushroom Pholiota nameko by hot aqueous extraction and purification. NMR methylation analyses of purified fraction (GHW-PN, 1.46% yield) indicated presence a (1 → 3)-linked β-D-glucan, highly substituted (~27%) at O-6 single units β-D-Glcp or 6)-β-D-Glcp fragments. The β-glucan (at 0.5, 1, 2%) showed shear thinning behavior when concentration solution increased, there an increase in apparent viscosity. presented gel-like thermal stability under...
Yellow passion fruit peel (PFP) is considered an important source of dietary fibre (DF) and its consumption has been associated with health benefits in metabolic gut disturbs. This work aimed to characterize the chemical structure soluble DF (SDF) from PFP evaluate gastroprotective activity acute gastric-ulcer model induced by ethanol rats. SDF was composed 92% GalA presented high methyl esterified homogalacturonan (DE = 70%), relative Mw 53 kDa. Oral pre-treatment animals (0.1, 1 10 mg/kg)...
Aims: The covalent linking of nonsteroidal anti-inflammatory drugs to a hydrogen sulfide (H2S)-releasing moiety has been shown dramatically reduce gastrointestinal (GI) damage and bleeding, as well increase analgesic potency. We have tested the hypothesis that an H2S-releasing derivative ketoprofen (ATB-352) would exhibit enhanced efficacy without significant GI in mouse model allodynia/hyperalgesia. Results: ATB-352 was significantly more potent effective than did not elicit damage....
Rhamnogalacturonan (RGal) is a polysaccharide isolated from Acmella oleracea that ameliorates the intestinal barrier in an ulcerative colitis model induced by dextran sulfate sodium (DSS) and Caco-2 cells. Here we investigate if RGal could reduce visceral pain, inflammation, oxidative stress gastrointestinal dysmotility. Acetic acid, capsaicin or mustard oil were used to assess pain normal mice. Ulcerative was with DSS (10 mg/kg) given orally for 7 days. reduced abdominal contortions, cell...
This study presents a new approach for identifying myeloperoxidase (MPO) inhibitors with strong in vivo efficacy. By combining inhibitor-like rules and structure-based virtual screening, the pipeline achieved 70% success rate discovering diverse, nanomolar-potency reversible hypochlorous acid (HOCl) scavengers. Mechanistic analysis identified RL6 as genuine MPO inhibitor RL7 potent HOCl scavenger. Both compounds effectively suppressed production cells neutrophils, showing superior inhibition...
ABSTRACT Background Hydrogen sulfide (H 2 S) is proposed to be a key regulator of inflammatory diseases; however, its role in the complex and often inadequately managed pathophysiology postoperative pain frequently mishandled. This study was undertaken elucidate endogenous H S recovery nociceptive thresholds using mouse model pain. Methods Male BALB/c mice (6–7 weeks) underwent sham or plantar incision surgery (PIS). Thermal mechanical were assessed before 1–7 days post‐PIS. At 1, 4 7...
Naringenin (NG) is a flavanone abundant in grapefruit and other citrus fruits that presents several pharmacological effects, such as antioxidant, anti-inflammatory, analgesic, among others. We investigated the antinociception of systemic administration naringenin some mechanisms action underlying its effect. Intraperitoneal NG (10 mg/kg) inhibited mechanical allodynia induced by partial sciatic nerve ligation (PSNL) carrageenan 65 ± 4 43 9% (2 h), respectively. also reduced writhes number...
Neuropathic and postoperative pain are clinical conditions that impair the quality of life. The current pharmacotherapy is ineffective accompanied by several side effects. In order to develop new therapeutics targets, secondary metabolites plants have been extensively studied. Acmella oleracea (“jambu”) a native plant from Amazon rich in alkylamides, bioactive compounds responsible induce anesthetic chemesthetic sensations. We previously demonstrated intraplantar administration an hexanic...