A5018474821- Axon Guidance and Neuronal Signaling
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Memory and Neural Mechanisms
Montreal Neurological Institute and Hospital
2018-2024
McGill University
2018-2024
Abstract The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development expressed by neurons the mature brain. Netrin-1 recruits GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is critical long-term potentiation (LTP) at CA3-CA1 hippocampal Schaffer collateral synapses, while conditional DCC deletion from glutamatergic impairs hippocampal-dependent spatial memory severely disrupts LTP...
Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the postnatal and adult mammalian brain. netrin receptor DCC are both enriched at synapses. In hippocampus, activity-dependent secretion by potentiates glutamatergic synapse function, critical long-term potentiation, experimental cellular model learning memory. Here, we assessed impact neuronal expression...
Abstract The receptor deleted in colorectal cancer (DCC) and its ligand netrin-1 are essential for axon guidance during development expressed by neurons the mature brain. Netrin-1 recruits GluA1-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is critical long-term potentiation (LTP) at CA3-CA1 hippocampal Schaffer collateral synapses, while conditional DCC deletion from glutamatergic impairs hippocampal-dependent spatial memory severely disrupts LTP...
Netrin-1 was initially characterized as an axon guidance molecule that is essential for normal embryonic neural development; however, many types of neurons continue to express netrin-1 in the post-natal and adult mammalian brain. netrin receptor DCC are both enriched at synapses. In hippocampus, activity-dependent secretion by potentiates glutamatergic synapse function, critical long-term potentiation, experimental cellular model learning memory. Here, we assessed impact neuronal expression...
ABSTRACT In the mature CNS, netrin-1 is expressed by neurons and oligodendrocytes implicated in stability of axo-oligodendroglial paranodal junctions. Here we report that netrin receptor UNC5B highly enriched at paranodes. We demonstrate paranodes become disorganized following conditional deletion oligodendrocytes, with disruption interface between glial loops detachment from axon. As a result, Caspr1 Kv1.1 disperse along axon, internodes fail to lengthen compact myelin periodicity reduced....
Abstract The ability of the mammalian brain to maintain spatial representations external or internal information for short periods time has been associated with sustained neuronal spiking and reverberatory neural network activity in medial entorhinal cortex. Here, we show that cholinergic activation muscarinic receptors on cortical neurons mediates plasma membrane recruitment netrin-1 receptor deleted-in-colorectal cancer (DCC) promote receptor-mediated persistent firing. Conditional...