A5051676873- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Immune Cell Function and Interaction
- Colorectal and Anal Carcinomas
- Cutaneous Melanoma Detection and Management
- Melanoma and MAPK Pathways
- Microscopic Colitis
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Protein Kinase Regulation and GTPase Signaling
- Cancer Cells and Metastasis
- Brain Metastases and Treatment
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- Endometrial and Cervical Cancer Treatments
- Tracheal and airway disorders
- RNA regulation and disease
- COVID-19 Clinical Research Studies
- Lung Cancer Research Studies
German Cancer Research Center
2023-2025
Heidelberg University
2023-2025
All India Institute of Medical Sciences
2019-2023
Maulana Azad Medical College
2018
University of Delhi
2018
Background Immune checkpoint inhibitors (ICIs) are the gold standard therapy in patients with deficient mismatch repair (dMMR)/microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC). A significant proportion of show resistance, making identification determinants response crucial. Growing evidence supports role sex determining susceptibility to anticancer therapies, but data is lacking for MSI-H CRC. Methods In this real-world cohort comprising 624 mCRC receiving ICIs, we...
Abstract Purpose: The Immunoscore predicts colorectal cancer prognosis but faces adoption barriers because of complex software and reimbursement issues. This study used open-source methods to explore a simplified prognostic model in nonmetastatic by focusing on single T-cell markers. Experimental Design: A multicentric prospective cohort patients with assessed CD3+ CD8+ tumor-infiltrating lymphocytes (TIL) the invasive margin (IM) tumor core (TC) using QuPath. An immune cell score (ICS),...
<div>AbstractPurpose:<p>The Immunoscore predicts colorectal cancer prognosis but faces adoption barriers because of complex software and reimbursement issues. This study used open-source methods to explore a simplified prognostic model in nonmetastatic by focusing on single T-cell markers.</p>Experimental Design:<p>A multicentric prospective cohort patients with assessed CD3<sup>+</sup> CD8<sup>+</sup> tumor-infiltrating lymphocytes (TIL) the...
<p>Supplementary Figures</p>
Abstract Background This study aims to analyze risk factors, clinical profiles, treatment protocols, and disease outcomes in histologically proven resectable vulvar cancer (VC) patients according tumor stage. is a retrospective analysis of prospectively collected database 20 VC from May 2014 June 2019. Results The mean age diagnosis was 55 years, with range 38–84 years. incidence four cases per year. significantly more post-menopausal (65%) multiparous (90%) women. According FIGO staging...
Background: Carcinoma ovary is very rarely associated with paraneoplastic cerebellar degeneration (PCD). The first clinical manifestations of primary malignancy could be symptoms. presence specific serum onconeural antibodies (Abs) in ataxia patients may guide clinicians to search for the tumor by different investigation modalities. Case: A 71-year female presented symptoms gait and urinary incontinence. There were high levels anti-Yo Ab rapid progression no known etiology, which led...
Abstract Introduction The AJCC eighth edition TNM classification for lung cancer was released in 2017 and included major newer modifications. External validation studies have evaluated the efficacy of new system obtained paradoxical results. Methods A meta-analysis performed these to evaluate classification. Eight eligible with 654,185 patients were analysis. Hazard ratios (HRs) associated 95% confidence intervals extracted from identified studies. primary outcomes survival discrimination...