A5055354387- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- interferon and immune responses
- Sarcoma Diagnosis and Treatment
- Bone Metabolism and Diseases
- Cancer Cells and Metastasis
- Immune cells in cancer
- Civil and Structural Engineering Research
- Bone fractures and treatments
- Seismic Waves and Analysis
- Orthopaedic implants and arthroplasty
- Geophysical Methods and Applications
- Virus-based gene therapy research
- Immune Cell Function and Interaction
- Bone Tissue Engineering Materials
- Total Knee Arthroplasty Outcomes
- TGF-β signaling in diseases
- Ultrasonics and Acoustic Wave Propagation
- Viral Infections and Vectors
University of Calgary
2020-2023
Alberta Bone and Joint Health Institute
2020-2023
Canadian Orthopaedic Foundation
2020
Clinical Orthopaedics and Related Research
2020
The putative benefit of rhBMP-2 is in the setting limb reconstruction using structural allografts, whether it be allograft-prosthetic composites, osteoarticular or intercalary segmental grafts. There are also potential advantages augmenting osseointegration uncemented endoprosthetics and reducing infection. Recombinant human BMP-2 might mitigate nonunion allograft augmented osteosarcoma salvage surgery; however, its use limited because concerns about prooncogenic effects agent.(1) To assess...
Introduction Soft tissue sarcomas (STS) are highly metastatic, connective-tissue lineage solid cancers. Immunologically, frequently characterized by a paucity of tumor infiltrating lymphocytes and an immune suppressive microenvironment. Activation the STING pathway can induce potent immune-driven anti-tumor responses within immunogenic tumors; however, this strategy has not been evaluated in immunologically cold sarcomas. Herein, we assessed therapeutic response intratumoral activation...
Sarcomas are rare, difficult to treat, mesenchymal lineage tumours that affect children and adults. Immunologically-based therapies have improved outcomes for numerous adult cancers, however, these therapeutic strategies been minimally effective in sarcoma so far. Clinically relevant, immunologically-competent, transplantable pre-clinical models essential advance immunology research. Herein we show Cre-mediated activation of Kras G12D , deletion Trp53 the hindlimb muscles C57Bl/6 mice...
In inhomogeneous media with constituents having very different acoustic properties, strong multiple scattering of ultrasonic waves can occur, especially when the wavelength is comparable length scales over which constituent properties vary. Such lead to a long “coda” that dominates observable behaviour in pulsed experiments, and dwarf ballistic pulse travels coherently through medium. many cases, transport energy by multiply scattered be well described using diffusion approximation, may even...
<h3>Background</h3> Soft tissue sarcomas (STSs) are a heterogeneous group of malignancies that arise from mesodermal tissue. Generally, STSs treated with morbid surgical resection and radiation therapy.<sup>1</sup> The STS tumour microenvironment (TME) contains an abundance macrophages<sup>2</sup> few lymphocytes.<sup>3</sup> In many malignancies, macrophages can be associated progression<sup>4</sup> suppression lymphocytes.<sup>5</sup> role in needs further investigation. Therefore, the...
<h3>Background</h3> Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive and metastatic soft tissue that resistant to most conventional systemic therapies immunotherapies.<sup>1–5</sup> Activation of the STimulator INterferon Genes (STING) pathway an emerging immunotherapeutic strategy can be used recruit effector lymphocytes into TME induce tumour eradication.<sup>6–9</sup> In murine model UPS, we have demonstrated intra-tumoural (i.t.) administrations murine-specific STING...