A5076658042- Plant Pathogens and Fungal Diseases
- Organ Transplantation Techniques and Outcomes
- Computational Drug Discovery Methods
- Nail Diseases and Treatments
- Clinical Nutrition and Gastroenterology
- Fungal Biology and Applications
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- BRCA gene mutations in cancer
- Botany and Plant Ecology Studies
- Xenotransplantation and immune response
- Metabolomics and Mass Spectrometry Studies
- Frailty in Older Adults
- Diabetes Management and Education
- Music Therapy and Health
- Childhood Cancer Survivors' Quality of Life
- Bryophyte Studies and Records
- Breast Implant and Reconstruction
- Histone Deacetylase Inhibitors Research
- Neurological Complications and Syndromes
- Mollusks and Parasites Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Marine and Coastal Research
- Health Promotion and Cardiovascular Prevention
- Catholicism, Bioethics, Media, Education
National Center for Advancing Translational Sciences
2020-2024
University of Pennsylvania
2024
Kennesaw State University
2024
National Institutes of Health
2022
Christiana Care Health System
2021
Society of Thoracic Surgeons
2017
Valve (United States)
2017
Emory and Henry College
2017
University of Chicago
2010-2016
Lehigh Valley Hospital
2015
field is purely objective, and the information discussed essential to internist general practitioner.
Abstract The immunosuppressive metabolite of leflunomide, A77 1726, inhibits the enzymatic activity protein tyrosine kinases and dihydro-orotic acid dehydrogenase, an enzyme involved in pyrimidine biosynthesis. Here murine CTLL cell lines were studied to determine which biochemical targets 1726 was responsible for observed inhibition proliferation cytotoxic activity. At low concentrations biosynthesis is target, since correlates with a reduction NTP levels reversed by uridine. higher uridine...
Hepatic metabolic stability is a key pharmacokinetic parameter in drug discovery. Metabolic usually assessed microsomal fractions and only the best compounds progress discovery process. A high-throughput single time point substrate depletion assay rat liver microsomes (RLM) employed at National Center for Advancing Translational Sciences. Between 2012 2020, RLM data was generated ~ 24,000 from more than 250 projects that cover wide range of pharmacological targets cellular pathways. Although...
Efficiently circumventing the blood-brain barrier (BBB) poses a major hurdle in development of drugs that target central nervous system. Although there are several methods to determine BBB permeability small molecules, Parallel Artificial Membrane Permeability Assay (PAMPA) is one most common assays drug discovery due its robust and high-throughput nature. Drug long costly venture, thus, any advances streamline this process beneficial. In study, ∼2,000 compounds from over 60 NCATS projects...
Problems with drug ADME are responsible for many clinical failures. By understanding the properties of marketed drugs and modeling how chemical structure contributes to these inherent properties, we can help new projects reduce their risk profiles. Kinetic aqueous solubility, parallel artificial membrane permeability assay (PAMPA), rat liver microsomal stability constitute Tier I assays at National Center Advancing Translational Sciences (NCATS). Using recent data generated from in-house...
In the present work observations were made of growth certain pathogenic fungi on hair. Bonar and Dreyer used bundles hair inoculated with trichophyton interdigitale to test antiseptic properties solutions. Tona observed in tube. The various (dermatophytes) a medium scalp products seems have received little attention. consisted barber shop cleansed water, placed petri dishes tubes autoclaved. It was found necessary keep moist distilled water by adding an amount sufficient cover mat Growth...
A study of the growth pathogenic fungi on a mixture barber shop hair and scalp products adults was reported. In this paper results children under 12 years, before after extraction with ether, are The divided into 2 portions one portion extracted ether for 24 hours in Soxhlet. Portions material were placed test tubes, moistened distilled water autoclaved. Plants made unextracted Sabourauds'proof medium following saprophytes, Lichtheimia sp. Scopulariopsis brevicaulis; Achorion schoenleinii,...
A study was made of the growth pathogenic fungi on hair and scalp products before puberty, as collected after extraction with ether in a Soxhlet for 24 hours. similar men women is here reported. Care taken that this clean, untreated undyed. The numerous individuals different ages mixed. About 6 cc. placed test tubes, covered distilled water, tubes plugged cotton autoclaved. following 2 non-pathogenic saprophytes Lichthemia sp. Scopulariopsis brevicaulis were studied: Achorion schoenleinii,...
We report the discovery of an imidazopyridine series IRAK1/4/pan-FLT3 kinase inhibitors. Optimization this has produced compound 31 which displays potent and selective inhibition IRAK1, IRAK4, FLT3, all mutant forms as well good in vitro ADME pharmacokinetic properties. In a mouse xenograft model AML, produces survival prolongation equal to that Gilteritinib, leading marketed FLT3 inhibitor currently used treat AML.
Background. Our aim was to study the impact of clinical acute rejection (CR) and subclinical (SR) on outcomes in kidney transplant recipients treated with rapid steroid withdrawal (RSW). Methods. All patients who received a living or deceased donor were RSW included. The primary outcome death-censored graft survival. Biopsies Banff borderline changes included groups. Results. 457 included; 46 (10%) experienced SR, 36 (7.8%) had CR. Mean HLA mismatch significantly higher CR group. grade There...
To examine the impact of a nurse-led intervention on anxiety levels and perceived self-efficacy to cope in patients receiving first-time chemotherapy using customized prechemotherapy educational virtual reality (VR) video.35 with cancer participated this study at large suburban center Newark, Delaware.A single-group, quasi-experimental pilot was conducted feasibility VR video chemotherapy. The State-Trait Anxiety Inventory, heart rate, blood pressure were used measure anxiety, Cancer...
The perinucleolar compartment (PNC) is a dynamic subnuclear body found at the periphery of nucleolus. PNC enriched with RNA transcripts and RNA-binding proteins, reflecting different states genome organization. prevalence positively correlates cancer progression metastatic capacity, making it useful marker for progression. A high-throughput, high-content assay was developed to identify novel small molecules that selectively reduce in cells. We identified further optimized pyrrolopyrimidine...
Previous research has outlined evident disparities in the prevalence of chronic conditions among African Americans compared to other groups, with low-income American men disproportionately affected by almost every disorder. Self-management programs are useful tools for managing disorders beyond doctor's office. This monograph provides a detailed looking into current state on health conditions. An intersectional approach is used provide nuanced synthesis relevant literature. The project...
In order to investigate the changes occasioned by light and darkness in retinal elements of a Urodele series experiments on large (37 45 mm.) larval recently metamorphosed individuals Amblystoma was carried out. It found that pigment these eyes undergoes decided forward movement when animals are transferred from light. most is massed near base epithelial cells, only comparatively few needles extend into protoplasmic processes between visual cells. decidedly greater amount moves toward...
e17628 Sources of Information and Influence on Decisions Regarding Contralateral Prophylactic Mastectomy: A Prospective Study Background: Little is known about what influences a woman's decision to undergo contralateral prophylactic mastectomy (CPM). We hypothesized that different types information influence women diferently depending the patient's age, race type surgical procedure. Methods: 55-item survey validated with breast cancer survivors was administered 82 patients before surgery....
71 Background: Contralateral prophylactic mastectomy (CPM) rates are increasing but it is unclear how many patients consider CPM prior to their surgery. Methods: We developed a 55 item survey validated with 20 breast cancer survivors which was administered newly diagnosed (n=136) at two institutions surgery determine factors associated treatment preference. Results: The median age 58 years (range 30-85). Eighty-three (69.2%) were White. Thirty-eight (28.6%) of had 1st degree relative cancer....