A5089188116- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Diabetes and associated disorders
- Thyroid Disorders and Treatments
- Diabetes Management and Research
- Human Health and Disease
- Obesity and Health Practices
- Lipid metabolism and disorders
- Pancreatic function and diabetes
- Healthcare Systems and Public Health
- Childhood Cancer Survivors' Quality of Life
- Medical and Biological Sciences
- Pituitary Gland Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Obesity, Physical Activity, Diet
- Hypothalamic control of reproductive hormones
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Amino Acid Enzymes and Metabolism
- Celiac Disease Research and Management
- Adrenal Hormones and Disorders
- Congenital heart defects research
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
Bashkir State Medical University
2017-2024
Russian Children's Clinical Hospital
2022
Abstract Context Somatrogon is a long-acting recombinant human growth hormone (rhGH) in development for once-weekly treatment of children with deficiency (GHD). Objective We aimed to compare the efficacy and safety somatrogon once-daily somatropin prepubertal GHD. Methods In this 12-month, open-label, randomized, active-controlled, parallel-group, phase 3 study, participants were randomized 1:1 receive (0.66 mg/kg/week) or (0.24 12 months. A total 228 (boys aged 3-11 years, girls 3-10 years)...
Childhood obesity is an urgent problem of pediatric endocrinology due to the widespread occurrence, development metabolic complications and their steady tracking into adulthood. The developed clinical guidelines are main working tool practitioner. They briefly structurally present information about epidemiology modern classification obesity, methods its diagnosis treatment based on principles evidence-based medicine.
Abstract Context: TransCon Growth Hormone (GH) (Ascendis Pharma) is a long-acting recombinant sustained-release human GH prodrug in development for children with deficiency (GHD). Objective: To compare the pharmacokinetics, pharmacodynamics, safety, and efficacy of weekly to that daily prepubertal GHD. Design: Randomized, open-label, active-controlled study three doses versus Genotropin (Pfizer). Setting: Thirty-eight centers 14 European countries Egypt. Patients: Prepubertal male female...
Abstract Purpose The objectives of the ongoing, Phase 3, open-label extension trial enliGHten are to assess long-term safety and efficacy weekly administered long-acting growth hormone lonapegsomatropin in children with deficiency. Methods Eligible subjects completing a prior 3 parent (heiGHt or fliGHt) were invited participate. All treated lonapegsomatropin. Subjects United States switched TransCon hGH Auto-Injector when available. Endpoints safety, annualized height velocity,...
This international, Phase 3, open-label extension trial evaluated the long-term safety and efficacy of once-weekly lonapegsomatropin in children with growth hormone deficiency (GHD). Conducted across 63 sites (15 countries), enliGHten enrolled GHD who previously participated a 3 (heiGHt or fliGHt). Participants received subcutaneous injections dosed at 0.24 mg hGH/kg/week. Safety was monitored through adverse events, local tolerability, levels, metabolic parameters. Efficacy annualized...
Aim. To analyze the association of rs3730089 nucleotide sequence variant PIK3R1 gene with various metabolic disorders in patients type 1 diabetes mellitus (T1DM). Design. A one-stage cross-sectional study. Materials and methods. 147 unrelated T1DM were examined. Their height, body weight, waist hip circumferences, mass index measured. Laboratory tests included determination total cholesterol, high- low-density lipoprotein triglycerides. The was investigated using a polymerase chain reaction....
Childhood obesity is an urgent problem of pediatric endocrinology due to the widespread occurrence, development metabolic complications and their steady tracking into adulthood. The developed clinical guidelines are main working tool practitioner. They briefly structurally present information about epidemiology modern classification obesity, methods its diagnosis treatment based on principles evidence-based medicine.
BACKGROUND: Self-monitoring of blood glucose (SMBG) with glucometers provides only a snapshot the glycemic profile and is accompanied by significant psychological discomfort pain, especially in children. Flash Glucose Monitoring System — FreeStyle Libre (FSL) overcomes many barriers associated measurement improves metabolic control. AIM: To evaluate efficacy FSL children type 1 diabetes mellitus (T1DM) terms control, episodes severe hypoglycemia (SH) diabetic ketoacidosis (DKA). MATERIALS...
The precocious puberty is an urgent problem of pediatric endocrinology characterized by clinical and pathogenetic heterogeneity. appearance secondary sex characteristics before the age 8 years in girls 9 boys requires timely diagnosis appointment pathogenetically justified treatment order to achieve target indicators final growth prevent social deprivation. developed guidelines are main working tool practitioner. They briefly structurally present information about epidemiology modern...
Abstract Disclosure: Z. Zadik: None. N. Zelinska: Consulting Fee; Self; Novo Nordisk, Berlin-Chemie, Medtronic, Sanofi-Aventis. Research Investigator; MacroGenics, Pfizer, Inc., Merck, OPKO Health, Ferring Pharmaceuticals, Teva Pharmaceutical Industries Ltd., Parexel, Genexine. Speaker; ACINO, Sanofi-Aventis, Johnson &Johnson, Wörwag Pharma. V. Iotova: Grant Recipient; Inc. Swixx, Sandoz, Berlin-Chemie. Y. Skorodok: O.A. Malievskiy: Mauras: Agios. Abbvie. Abbvie, Beta Bionics. S.R....
Abstract Objectives: Somatrogon (hGH-CTP) is a long acting recombinant human growth hormone, consisting of the amino acid sequence hGH and three copies carboxy-terminal peptide (CTP) chorionic gonadotropin (hCG) being developed as once weekly treatment for children with pGHD. This report summarizes data from first year optional open-label extension (OLE) pivotal phase 3 global trial (ClinicalTrials. gov: NCT02968004), comparing efficacy safety switched Genotropin (rhGH; somatropin) to...
The thyroiditis in children are urgent problem of pediatric endocrinology due to the widespread occurrence and characterized by clinical pathogenetic heterogeneity. developed guidelines main working tool practitioner. They briefly structurally present information about epidemiology modern classification thyroiditis, methods their diagnosis treatment based on principles evidence-based medicine.
Continuous glucose monitoring is an effective method of glycaemia, allowing to achieve optimal glycemic control and reduce the risk complications type 1 diabetes mellitus in children. After approval new «Standard medical care for children with (diagnosis treatment)» (registered Ministry Justice Russia on 02/18/2021 No. 62543), hundreds lawsuits were initiated many regions country against regional public authorities field healthcare organizations demanding free supply systems continuous blood...
The description of the child aged 5 months with von Hippel-Lindau syndrome without any manifestations this is presented. reason for molecular genetic examination was presence cases in family (mother and sister). heterozygous variant c.355T>C p.F119L found VHL gene. An objective revealed no pathology. A comprehensive laboratory instrumental aimed at searching components syndrome, including a blood test metanephrines normetanephrines, ultrasound abdominal organs, fundus, also did not reveal...
Currently, monogenic forms of diabetes mellitus account for up to 6.5% all cases in children and adolescents. Among the 14 currently identified types MODY diabetes, most common are HNF4a-, GCK-, HNF1a-MODY. latter, GCK-MODY has mildest course, often not requiring drug therapy, with a favorable prognosis terms micro- macrovascular complications. The development molecular genetics makes it possible more accurately verify various mellitus, predict course disease, determine treatment tactics,...
Congenital hypothyroidism (CH) is an important issue of pediatric endocrinology. Early detection this disease and timely initiation treatment can prevent the development severe mental retardation. Neonatal screening for CH in Russian Federation has been conducted since 1993. Updated 2024 clinical guidelines are main tool a physicians. They briefly structurally present information about congenital hypothyroidism, its epidemiology modern classification, methods diagnosis treatment, based on...
Thyroiditis in children are important issues of pediatric endocrinology due to their widespread occurrence. They differ etiology, pathogenesis, and clinical manifestations. Updated guidelines 2024 the main working tool physicians. briefly structurally present information about epidemiology modern classification thyroiditis, methods diagnosis treatment based on principles evidence-based medicine.
Abstract Background: Somatrogon, a long-acting recombinant human growth hormone, is being developed as once weekly treatment for pediatric patients (pts) with GHD. A phase 2, 12 month study (NCT01592500) in pts GHD showed that somatrogon at 0.66 mg/kg/week had similar efficacy and safety to daily Genotropin. Pts who completed months of could be enrolled into an open-label extension (OLE). Aims: Evaluate the long-term exposure continued OLE up additional 5 years. Methods: Methods main 2 were...
Background: Currently more than 50 mutations of the INS gene are known to affect various stages insulin biosynthesis in beta cells pancreas. However only individual cases diabetes mellitus (DM) associated with heterozygous coding region were reported Russian Federation. We report a group patients clinical manifestation DM caused by both and non-coding regions gene. The mutation intron for first time Federation Materials methods : 60 an isolated course neonatal (NDM), 52 at age 7–12 months...
Abstract Objectives GX-H9 is a long-acting form of recombinant human GH under clinical development for both adults and children with GHD. In this report, 24-month efficacy safety once weekly every other week (EOW) administration were evaluated, in addition to Genotropin® switch-ability after 12-month treatment. Methods Subjects randomly assigned receive either one three doses (0.8 mg/kg/week, 1.2 mg/kg/week or 2.4 mg/kg week) 0.03 mg/kg/day Genotropin®. Treatment duration all patients arms...
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The aim of the present study was to evaluate exocrine pancreatic function in children with type 1 diabetes mellitus during course disease.Fecal elastase varied between 24.4 and 169.6 μg /g (median 134.5 /g) DM concomitant PEI. Number diarrhea not significantly different low levels those normal (43.0% versus 35.5%, p=0.359). remainder had fecal elastase-1 201.4 810.5 stool 650.7 /g). Differences patients without PEI comparison group were significant (p=0.112).Median daily fat excretion 8.31...