A5054107035- Cancer Treatment and Pharmacology
- Influenza Virus Research Studies
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Breast Cancer Treatment Studies
- Chronic Kidney Disease and Diabetes
- Sepsis Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- BRCA gene mutations in cancer
- Chemotherapy-related skin toxicity
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Genetic factors in colorectal cancer
- Hepatitis B Virus Studies
- DNA Repair Mechanisms
- Atrial Fibrillation Management and Outcomes
- Gout, Hyperuricemia, Uric Acid
- Colorectal Cancer Treatments and Studies
- Biliary and Gastrointestinal Fistulas
- Cancer Genomics and Diagnostics
- Veterinary medicine and infectious diseases
Luodong Poh-Ai Hospital
2010-2023
Chronic kidney disease (CKD) is significantly associated with lung cancer incidence. The aim of this study was to elucidate whether influenza vaccination reduces the incidence in patients CKD. This cohort enrolled a record CKD diagnosis from 2000 2012 Taiwan’s National Health Insurance Research Database. Included were divided into vaccinated and unvaccinated groups. In total 12,985 enrolled. Among these patients, 5495 7490 unvaccinated. risk lower group after adjusting for age, sex, dialysis...
Aims Paclitaxel is a widely used anti‐neoplastic agent but has low oral bioavailability due to gut extrusion by P‐glycoprotein (P‐gp). Oral paclitaxel could be more convenient, less resource intensive, and tolerable than intravenous administration. Encequidar (HM30181A) novel, minimally absorbed gut‐specific P‐gp inhibitor. We tested whether administration of with encequidar (oPac+E) achieved comparable AUC (IVP) 80 mg/m 2 . Methods conducted multi‐centre randomised crossover study two...
Abstract Background Radiotherapy (RT) following breast-conserving surgery (BCS) is mainly used to decrease the rate of ipsilateral breast tumor recurrence (IBTR) in women with ductal carcinoma situ (DCIS). Recent studies have demonstrated that low-dose tamoxifen significantly reduces IBTR DCIS. Here, we aim determine whether administration non-inferior RT preventing patients low-risk characteristics Methods/design This a prospective, international, open-label, randomized, non-inferiority...
The evolutionary trajectories that drive clinical and therapeutic consequences in localized breast cancers (BCs) with ipsilateral tumor relapse (IBTR) remain largely unknown. Analyses of longitudinal paired whole-exome sequencing data from 10 BC patients IBTR reveal that, compared to primary tumors, homologous recombination (HR) deficiency, inactivation the HR pathway, chromosomal instability, somatic driver mutations are more frequent. Furthermore, three major models evolution summarized,...
Patients with type 2 diabetes mellitus (T2DM) have a higher risk of chronic kidney disease (CKD) due to vascular complications and inflammation. T2DM contributes mortality morbidity related influenza. In Taiwan, influenza vaccination is recommended for patients T2DM. A previous meta-analysis reported the efficacy in reducing hospitalization diabetes; however, renal protective effect vaccine remains unclear. This study evaluated whether could reduce incidence CKD dialysis The cohort included...
The risk of stroke in patients with gout is high. effect vaccines lowering the remains unclear. We retrospectively analyzed 23,949 (age ≥ 55 years) from National Health Insurance Research Database over a 12-year period. were divided into vaccinated (n = 11,649) and unvaccinated groups 12,300). Overall, group had significantly lower risks all stroke, hemorrhagic ischemic than (adjusted hazard ratio [aHR], 0.59 95% confidence interval [CI], 0.55-0.63; aHR, 0.60 CI, 0.49-0.73; 0.55-0.65,...
Background and purpose: Paclitaxel is a widely used anti-neoplastic agent but has low oral bioavailability due to gut extrusion by P-glycoprotein (P-gp). Oral paclitaxel could be more convenient, less resource intensive, tolerable than intravenous administration. Encequidar (HM30181A) novel, minimally absorbed specific P-gp inhibitor. We tested whether administration of with encequidar (oPac+E) achieved comparable AUC (IVP) 80mg/m2. Experimental approach: conducted multi-centre randomised...
Background and purpose: Paclitaxel is a widely used anti-neoplastic agent but has low oral bioavailability due to gut extrusion by P-glycoprotein (P-gp). Oral paclitaxel could be more convenient, less resource intensive, tolerable than intravenous administration. Encequidar (HM30181A) novel, minimally absorbed specific P-gp inhibitor. We tested whether administration of with encequidar (oPac+E) achieved comparable AUC (IVP) 80mg/m2. Experimental approach: conducted multi-centre randomised...
There is evidence of strong association between influenza infections and stroke; however, the vaccination its effect on strokes currently unclear. In present study, Taiwan’s National Health Insurance Database was used in obtaining data for study subjects 55 years older diagnosed with hypertension (n = 59,251; 25,266 vaccinated 33,985 unvaccinated subjects) from 2001–2012. Propensity scores were calculated using a logistic regression model to determine effects by accounting covariates that...
Objective: Although influenza vaccination reduces the risk of atrial fibrillation (AF), its protective effect in patients with gout remains unclear. The present study aimed to evaluate gout. Methods: A total 26,243 gout, aged 55 and older, were enrolled from National Health Insurance Research Database (NHIRD) between 1 January 2001, 31 December 2012. divided into vaccinated (n = 13,201) unvaccinated groups 13,042). After adjusting comorbidities, medications, sociodemographic characteristics,...
Previous studies have indicated that influenza vaccination reduces the development of lung cancer. However, protective effects on primary liver cancer in patients with chronic kidney disease (CKD) are unclear. This cohort study identified 12,985 aged at least 55 years who had received a diagnosis CKD between 1 January 2001 and 31 December 2012 from National Health Insurance Research Database Taiwan. The were classified according to status. Propensity score matching was used reduce selection...