A5063183825- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Autoimmune and Inflammatory Disorders Research
- Psoriasis: Treatment and Pathogenesis
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Dermatological and Skeletal Disorders
- Inflammatory Myopathies and Dermatomyositis
- Biosimilars and Bioanalytical Methods
- Viral Infections and Immunology Research
- Urticaria and Related Conditions
- Hematological disorders and diagnostics
- Dermatological and COVID-19 studies
- Bone and Joint Diseases
- Systemic Sclerosis and Related Diseases
- Skin and Cellular Biology Research
- Metabolism and Genetic Disorders
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Eosinophilic Disorders and Syndromes
- S100 Proteins and Annexins
Nethradhama Superspeciality Eye Hospital
2015-2024
SDM College of Medical Science and Hospital
2015-2022
St.John's Medical College Hospital
2020-2022
Vikram Hospital
2022
Fortis Hospital
2022
Manipal Hospital
2022
Sparsh Hospital
2022
Columbia Asia
2022
Bhagwan Mahaveer Jain Hospital
2022
JSS Medical College and Hospital
2022
Abstract Aim In this study, efficacy, tolerability and safety of biosimilar adalimumab (Exemptia; Zydus Cadila) was compared with reference (Humira; AbbVie) in patients moderate to severe rheumatoid arthritis ( RA ). Method multicentre, prospective, randomized, double‐blind, active controlled parallel arm 120 were given 40 mg either test (Exemptia) or (Humira) by subcutaneous route every other week for 12 weeks. The primary endpoint proportion responders two tretament groups American College...
<ns4:p>Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, is associated with hyperinflammation cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, being used manage storm in patients. However, extensive use corticosteroids leads serious adverse events disruption gut-lung axis. Various...
The study discusses the case of a patient with known rheumatoid arthritis (RA) who presented sudden-onset gangrene left little finger, accompanied by severe pain. Despite elevated inflammatory markers, normal echocardiogram, and negative autoimmune screenings, was diagnosed RA-associated medium vessel vasculitis. Initial treatment pulse steroids; however, subsequent development pain in radial artery distribution prompted further investigation. Angiography revealed narrowing ulnar arteries,...
Localized lupus pernio (LP) is a rare manifestation of chronic sarcoidosis. This presents case 46-year-old female with one-year history painful upper lip nodule and occasional oral ulcers. HRCT (high-resolution computed tomography) chest abdomen histopathology confirmed localized sarcoidosis without systemic involvement. Treatment hydroxychloroquine (200 mg daily) tapering corticosteroid regimen led to significant improvement within two months. LP, marked by violaceous facial plaques, often...
Background AnnexinA2 (AnxA2) membrane deposition has a critical role in HB-EGF shedding as well IL-6 secretion breast cancer cells. This autocrine cycle major cell proliferation, migration and metastasis. The objective of the study is to demonstrate annexinA2-mediated regulation via Her-2 negative progression. Methods Secretory annexinA2, were analysed peripheral blood sample ( n = 20) positive patients 16). Simultaneously, tissue expression was by immunohistochemistry. these secretory...
Introduction Identifying factors predicting adverse pregnancy outcomes involving systemic lupus erythematosus (SLE) is a research priority. The aims of this study were to investigate (a) the maternal and fetal pregnant patients associated with outcomes, (b) effect on disease activity these patients. Methods This was an ambi-directional collecting information from five multi-specialist referral centres across state Karnataka, India over 5 years (2013–2018). Clinical details pregnancies that...
The aims were to demonstrate pharmacokinetic (PK) similarity between DRL_RI, a proposed rituximab biosimilar, and two reference innovator products (Rituxan® [RTX-US] MabThera® [RTX-EU]) compare their pharmacodynamics (PD), efficacy, safety, immunogenicity in rheumatoid arthritis (RA) patients with inadequate response methotrexate (MTX)-based therapy no prior biologic administration. In this randomized, double-blind, parallel-group study, 276 moderate-to-severe active RA randomized receive...
The aim was to study the prevalence of comorbidities in rheumatoid arthritis (RA) patients everyday clinical practice and their association with disease-specific demographic factors. multi-center recruited 3,247 (at 14 centers, 265) were excluded due incomplete data. number subjects considered for analysis 2982. mean (±standard deviation) age 48.98±12.64 years male-to-female ratio 1:5. data collected based on a pre-structured pro forma by trained research associates through interview...
Aim: Ankylosing spondylitis (AS) is a chronic inflammatory arthritis mainly affecting articular and extraarticular structures. AS clinical manifestations also involve sacroiliac joints spine. Genetic factors play key role in susceptibility. AS-associated subtypes of human leukocyte antigen (HLA)-B27 other HLA-B alleles vary different ethnic populations. There are no reports HLA B genotype association to South Indian patients. In the current study, we have analyzed with 105 patients 100...
Abstract Background We conducted this study to identify the influence of prolonged use hydroxychloroquine (HCQ), glucocorticoids and other immunosuppressants (IS) on occurrence outcome COVID-19 in patients with autoimmune rheumatic diseases (AIRDs). Methods This was a prospective, multicenter, non-interventional longitudinal across 15 specialist rheumatology centers. Consecutive AIRD treatment were recruited followed up longitudinally assess parameters contributing development its outcome....
To study the prevalence of remission in rheumatoid arthritis (RA) patients and influence different factors like literacy, socioeconomic status, presence comorbidity treatment strategy achieving remission.The involved 1990 RA who were recruited for Karnataka Rheumatoid (KRAC) study. Based on evaluated, participants classified as follows: age, < 30 years, 30-39 40-49 50-59 years ≥ 60 years; educational illiterate/no formal education, high school or less, graduate, post-graduate doctorate;...
Background: Patients with autoimmune rheumatic diseases (AIRD) may be at an increased risk for COVID-19 infection and poorer outcomes when compared the general population. We undertook this study to estimate of in our AIRD population determine parameters which contribute its occurrence. Methods: prospectively recruited all consecutive patients on immunosuppressive therapy from 14 specialist rheumatology centers across south Indian state Karnataka during current pandemic followed them...
To estimate the prevalence of extra-articular manifestations (EAM) in rheumatoid arthritis (RA) patients and impact demographic, clinical treatment factors.The study was carried out as a part 'Karnataka Rheumatoid comorbidity (KRAC) study' conducted at 14 centers across Karnataka, India between September 2014 July 2015. The data were collected by trained research associates using structured pro forma, under supervision consulting rheumatologists. Based on factors evaluated, participants...
Abstract Introduction We assessed the risk factors and outcome of COVID-19 in patients with autoimmune rheumatic diseases(AIRD) who contracted infection while on background treatment tofacitinib. Methods This is a non-interventional, cross-sectional, questionnaire based telephonic study which included consecutive AIRD tofacitinib co-treatment. Data related to subset, disease modifying anti drugs(DMARDs) including glucocorticoids comorbidities, was collected from 7 rheumatology centers across...
Introduction: Comorbidities frequently accompany psoriasis and psoriatic arthritis (PsA) add to the disease burden. We aimed identify comorbidity burden in patients with PsA evaluate its impact on activity measures our geographic region. Methods: This was a multicenter, cross-sectional study involving consecutive from 17 rheumatology centers. Their variables comorbidities were recorded. Results: In 549 enrolled patients, mean age 39.2 (14.9) years, male predominance (6:5). The duration of...
Abstract Aim The use of healthcare resources by rheumatoid arthritis (RA) patients can be related to the presence disease, comorbid conditions, steroids, and combined immunosuppressants. This study evaluated risk factors associated with infection hospitalization in RA. Methods multicenter, cross‐sectional enrolled 3247 RA subjects fulfilling 2010 American College Rheumatology/European League Against Rheumatism criteria examine prevalence episodes documentable non‐tubercular infections as a...
Alkaptonuria is a very rare disease that can cause premature degenerative arthritis of the spine and peripheral large joints. I present here case middle-aged woman who developed low back pain secondary to alkaptonuria.
Multicentric reticulohistiocytosis is a rare disease of unknown etiology. The skin, mucosa, synovial, bone and internal organs may be involved. Cutaneous nodules distinctive arthritis are the most prominent clinical features. pathogenesis MRH but probably has an immunologic basis. A 32-year-old female presented with multiple, painless tender on dorsum her hands, forearms elbows. histopathological study confirmed diagnosis multicentric reticulohistiocytosis.
This case study presents the clinical journey of a 37-year-old woman who previously experienced gangrene in her fingers and toes. Initial assessments revealed elevated total white blood cell count platelets, coupled with low hemoglobin levels. Despite normal inflammatory markers negative results for antiphospholipid syndrome, antinuclear antibodies, anti-neutrophil cytoplasmic arterial Doppler imaging displayed no abnormalities. Suspecting vasculitis, patient was initially treated steroids...