A5090332206- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Synthesis and Catalytic Reactions
- Peroxisome Proliferator-Activated Receptors
- Enzyme function and inhibition
- Liver Disease Diagnosis and Treatment
- Metal complexes synthesis and properties
- Neuropeptides and Animal Physiology
- RNA Interference and Gene Delivery
- Receptor Mechanisms and Signaling
- Ferrocene Chemistry and Applications
- MicroRNA in disease regulation
- Synthesis and biological activity
- Neuroscience and Neuropharmacology Research
- Genomics, phytochemicals, and oxidative stress
- Synthesis and Biological Evaluation
- Drug Transport and Resistance Mechanisms
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- PARP inhibition in cancer therapy
- Click Chemistry and Applications
- Adipose Tissue and Metabolism
- CRISPR and Genetic Engineering
University of Chieti-Pescara
2018-2023
Gliomas are the most aggressive adult primary brain tumors. Expression of inducible Nitric Oxide Synthase has been reported as a hallmark chemoresistance in gliomas and several studies have that inhibition could be related to decreased proliferation glioma cells. The present work was analyze molecular effects acetamidine derivative compound 39 (formally CM544, N-(3-{[(1-iminioethyl)amino]methyl}benzyl) prolinamide dihydrochloride), newly synthetized iNOS inhibitor, C6 rat cell model. There...
Nitric oxide is an important inflammation mediator with a recognized role in the development of different cancers. Gliomas are primary tumors central nervous system poor prognosis, and expression inducible nitric synthase correlates degree malignancy, changes vascular reactivity, neo-angiogenesis. Therefore, targeting biosynthesis appears as potential strategy to impair glioma progression. In present work set aryl amido-aryl acetamidine derivatives were synthesized obtain new potent...
FXR is a member of the nuclear receptor superfamily, which regulates expression various genes involved in bile acid, lipid and glucose metabolism. Targeting with small molecules has been exploited to treat lipid-related disorders diseases such as cholestasis, gallstones hepatic disorders. In this work, we expand existing pool known agonists using fast hit-to-lead structure-based pharmacophore docking screening protocol. A set 25 was selected after large database commercial chemicals,...
PPAR agonists represent a new therapeutic opportunity for the prevention and treatment of neurodegenerative disorders, but their pharmacological success depends on favourable pharmacokinetic properties capability to cross BBB.
first_page settings Order Article Reprints Font Type: Arial Georgia Verdana Size: Aa Line Spacing: Column Width: Background: Open AccessAbstract Inhibitors of the Inducible Nitric Oxide Synthase as Antiglioma Agents † by Cristina Maccallini *, Marialucia Gallorini, Pasquale Amoia, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Letizia Giampietro, Amelia Cataldi and Rosa Amoroso Department Pharmacy, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31,...
Triple negative breast cancer (TNBC) is a specific subtype, and poor prognosis associated to this tumour when it in the metastatic form. The overexpression of inducible Nitric Oxide Synthase (iNOS) considered predictor outcome TNBC patients, enzyme reported as valuable molecular target compromise progression. In work, new amidines containing benzenesulfonamide group were designed synthesized selective iNOS inhibitors. An vitro biological evaluation was performed assess compounds activity...