A5048520243- Medicinal Plant Research
- Enzyme-mediated dye degradation
- Pharmaceutical and Antibiotic Environmental Impacts
- Essential Oils and Antimicrobial Activity
- bioluminescence and chemiluminescence research
- Antimicrobial Peptides and Activities
- Moringa oleifera research and applications
- Autophagy in Disease and Therapy
- Electrochemical sensors and biosensors
- Career Development and Diversity
- Covalent Organic Framework Applications
- Advanced Nanomaterials in Catalysis
- Medicinal Plants and Neuroprotection
- Phytochemical compounds biological activities
- Analytical chemistry methods development
- Machine Learning in Bioinformatics
- Pharmacology and Nanomedicine Research
- Computational Drug Discovery Methods
- Biomedical and Engineering Education
- Nanoparticles: synthesis and applications
- Microwave Imaging and Scattering Analysis
- Ginger and Zingiberaceae research
- Innovative Teaching Methods
- Nanomaterials for catalytic reactions
- Fungal Biology and Applications
Khalifa University of Science and Technology
2020-2024
United Arab Emirates University
2015-2021
Abstract Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, investigated effect on migration, invasion, metastasis tumor growth TNBC Our current study revealed non-cytotoxic concentrations significantly inhibited migration blocked adhesion to fibronectin downregulated MMP-9 prostaglandin E 2 (PgE2). Not only did decrease their HUVECs lung...
Abstract Here we investigated the feasibility of using microwave spectroscopy for characterization normal and breast cancer cell lines cultured in vitro . Healthy non-tumorigenic, MCF-10A cancer, MDA-MB-231, Hs578T, T47D MCF-7 were electrically characterized open-ended coaxial probe technique from 200 MHz to 13.6 GHz. The dielectric constant, loss conductivity between non-tumorigenic cells analyzed their differences determined. Our results showed that four exhibited higher properties when...
Efficient enzyme immobilization is crucial for the successful commercialization of large-scale enzymatic water treatment. However, issues such as lack high loading coupled with leaching present challenges widespread adoption immobilized systems. The study describes development and bioremediation application an biocomposite employing a cationic macrocycle-based covalent organic framework (COF) hierarchical porosity horseradish peroxidase (HRP). intrinsic porous features azacalix[4]arene-based...
Abstract Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that ethanolic extract (RCE) inhibits proliferation these lines in a time- and concentration-dependent manner. RCE induced senescence cycle arrest at G1 phase. These changes were concomitant with upregulation p21, downregulation cyclin D1, p27, PCNA, c-myc, phospho-RB expression senescence-associated β-galactosidase activity. No proliferative recovery was detected after...
Colorectal cancer (CRC) is the third most common type of in terms incidence and mortality worldwide. Here we have investigated anti-colon potential Origanum majorana essential oil (OMEO) its underlying mechanisms action. We showed that OMEO significantly inhibited cellular viability colony growth human HT-29 colorectal cells. induced protective autophagy, associated with downregulation mTOR/p70S6K pathway, activated caspase-8 caspase-9-dependent apoptosis. Blockade autophagy 3-methyladenine...
Colorectal cancer is the fourth leading cause of cancer-related deaths worldwide. Here, we investigated anticancer effect Rhus coriaria extract (RCE) on HT-29 and Caco-2 human colorectal cells. We found that RCE significantly inhibited viability colony growth colon Moreover, induced Beclin-1-independent autophagy subsequent caspase-7-dependent apoptosis. Blocking by chloroquine reduced RCE-induced cell death, while blocking apoptosis had no death. Mechanistically, inactivated AKT/mTOR...
Colorectal cancer is considered as the third leading cause of death. In present study, we investigated potential anticancer effect and molecular mechanism Origanum majorana ethanolic extract (OME) against human colorectal cells. We showed that OME exhibited strong anti-proliferative activity in a concentration- time-dependent manner two cell lines (HT-29 Caco-2). inhibited viability, colony growth induced mitotic arrest HT-29 Also, DNA damage, triggered abortive autophagy activated caspase 3...
Dye-degrading peroxidases (DyPs) are increasingly finding applications in biotechnology owing to their broad substrate specificity and potential ability degrade recalcitrant organic dyes emerging pollutants. The presence accumulation of pollutants (EPs) water sources poses a pressing health environmental issue that necessitates the development greener more economical remediation approaches such as biological remediation. present study explores application recombinant thermophilic DyP from...
The accumulation of emerging pollutants in the environment remains a major concern as evidenced by increasing number reports citing their potential risk on and health. Hence, removal strategies such remain an active area investigation. One way through which can be eliminated from is enzyme-mediated bioremediation. Enzyme-based degradation further enhanced via advanced protein engineering approaches. In present study sensitive robust bioanalytical liquid chromatography-tandem mass...
Abstract The accumulation of toxic chemical constituents in sludge and wastewater has fuelled an interest investigating efficient eco-friendly remediation approaches. In this study, a set bacterial samples were isolated from petroleum tested for their ability to degrade different aromatic pollutants, including azo dyes emerging pollutants. Although exhibiting differential specificity, all isolates able classes efficiently. Ribosomal 16S rRNA sequencing the 12 showed that they belonged two...
In recent years, concerns are being raised about the potential harmful effects of emerging pollutants (EPs) on human and aquatic lives. Extensive research is conducted developing efficient remediation strategies to target this new class toxic pollutants. Studies focused biological (enzyme-based) methods have shown as greener possibly more economical alternatives other treatment approaches, such chemical methods. The current study use recombinantly produced novel bacterial peroxidases, namely...
Abstract The recent lockdown of laboratories in the COVID‐19 era has negatively impacted many lab‐based courses for undergraduate students; however, research project classes have been hardest hit. Unlike lecture courses, where lab instructors resorted to virtual experiments and videos substitute actual experiments, senior year independent which are supposed involve real research, struggling find an appropriate solution. A possible solution cases coronavirus pandemic led no or little...