A5069962855- Carbohydrate Chemistry and Synthesis
- Breast Lesions and Carcinomas
- Medical Imaging Techniques and Applications
- Cancer Diagnosis and Treatment
- Electrohydrodynamics and Fluid Dynamics
- Breast Cancer Treatment Studies
- Analytical Chemistry and Chromatography
- Radiopharmaceutical Chemistry and Applications
- Turbomachinery Performance and Optimization
- Cancer Treatment and Pharmacology
- Organometallic Complex Synthesis and Catalysis
- Medical Imaging and Pathology Studies
- Chemical Synthesis and Reactions
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Chemical Synthesis and Analysis
- Biopolymer Synthesis and Applications
- Combustion and flame dynamics
- Fermentation and Sensory Analysis
- biodegradable polymer synthesis and properties
- Combustion and Detonation Processes
- Microbial Metabolic Engineering and Bioproduction
- Advanced Control Systems Optimization
- Enzyme Catalysis and Immobilization
- Ultrasound and Cavitation Phenomena
Shizuoka City Shimizu Hospital
2025
Saitama Medical University
2009-2024
Ehime University
2021-2023
Saitama International Medical Center
2013-2022
Hiroshima Prefectural Hospital
2014-2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2011-2017
National Institutes of Health
2010-2017
Hiroshima University
1999-2016
Kumamoto University
2013
Tohoku University Hospital
2011
Abstract Therapeutic options for breast cancer patients with brain metastases (BM)/leptomeningeal carcinomatosis (LMC) are limited. Here, we report on the effectiveness and safety of trastuzumab deruxtecan (T-DXd) in human epidermal growth factor receptor 2-positive BM. Data were analyzed 104 administered T-DXd. Overall response rate (ORR), progression-free survival (PFS), overall (OS), intracranial (IC)-ORR, IC-PFS evaluated. ORR by investigator assessment was 55.7% (total population)....
Abstract We provide updated results (median follow-up duration: 20.4 months) of a retrospective study on the effectiveness trastuzumab deruxtecan (T-DXd) in patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer brain metastases (BM) and/or leptomeningeal disease (ROSET-BM). Median progression-free survival (PFS) was 14.6 months. overall (OS) not reached (NR); 24-month OS rate 56.0%. Subgroup analysis showed that median PFS 13.2 months analytical active BM,...
The FOXP3 mRNA expression and the other regulatory T cell-related molecules were investigated compared with clinicopathological parameters in human primary breast cancer. This study included 136 cancer patients operated our department from 2003 to 2006. Total RNA was extracted frozen normal tissues, of FOXP3, IL-10, TGFβ1 CCL22 evaluated using quantitative real-time RT-PCR. expressions significantly higher tissue than tissue, not only at pT1, 2, 3 stages but also DCIS stage. There positive...
We show the experimental data of selective ethanol separation from ethanol–water solution, using ultrasonic atomization. Pure could be obtained directly a solution with several mol% at 10 °C. This result can explained in terms parametric decay instability capillary wave, which high localization and accumulation acoustic energy occur, leading to That is, condenses longitudinal waves highly localized surface area causes
Methods for identifying sentinel lymph nodes (SNs) and their clinical significance have been established. Recent advances in molecular immunology enabled the analysis of precise immune responses. The objective current study was to clarify dendritic cell (DC) maturation, T-helper type 1 (Th-1) Th-2 responses, regulatory T-cell responses SNs patients with breast carcinoma.SNs non-SNs were identified by radioguided blue dye-guided methods 70 consecutive clinically node negative (N0) carcinoma....
Thyroid hormone (T3) plays diverse roles in adult organ function and during vertebrate development. The most important stage of mammalian development affected by T3 is the perinatal period when plasma level peaks. Amphibian metamorphosis resembles this postembryonic absolutely dependent on T3. ability to easily manipulate process makes it an ideal model study molecular mechanisms governing action functions mostly regulating gene expression through receptors (TRs). Studies vitro, cell...
Thyroid hormone (T3) plays an important role in regulating multiple cellular and metabolic processes, including cell proliferation, death, energy metabolism, vertebrates. Dysregulation of T3 signaling results developmental abnormalities, defects, even cancer. We used T3-dependent Xenopus metamorphosis as a model to study how regulates transcription during vertebrate development. exerts its metamorphic effects through receptors (TR). TR recruits, manner, cofactor complexes that can carry out...
Abstract Background Thyroid hormone (T3) is important for adult organ function and vertebrate development. Amphibian metamorphosis totally dependent on T3 offers a unique opportunity to study how controls postembryonic development in vertebrates. Earlier studies have demonstrated that TR mediates the metamorphic effects of Xenopus laevis . Liganded recruits histone modifying coactivator complexes target genes during metamorphosis. This leads nucleosomal removal modifications, including...
Abstract Some organometallic systems were found to be effective as catalysts for the polymerization of N‐carboxy‐DL‐alanine anhydride give poly‐α‐alanine. Organoaluminum catalyst produce water‐insoluble poly‐α‐alanine which was considered have a certain degree stereoregularity. A polymer prepared by triethylaluminum/(+)‐borneol system or (+)‐borneol alone optically active, dextrorotatory in dichloracetic acid, levorotatory acid/chloroform mixture.
Computed tomography of tracheopathia osteoplasticaH Onitsuka, N Hirose, K Watanabe, H Nishitani, Kawahira, Matsuura and ShigematsuAudio Available | Share
Abstract The copolymerization of N ‐carboxy‐ L ‐ and D ‐alanine anhydride with methanol as initiator was carried out. enantiomer excess in the starting monomer mixture is preferentially incorporated into polymer chains, demonstrating asymmetric selection during ‐copolymerization. mechanism asymmetric‐selective polymerization α‐amino acid NCA discussed terms stereoregulation by molecular asymmetry growing chain.
The aim of this study was to evaluate the significance Ki67 labeling index and p53 status as prognostic predictive indicators operable estrogen receptor (ER)-positive human epidermal growth factor 2 (HER2)-negative breast cancer. Among 697 consecutive patients with primary cancer who underwent curative surgery between 2002 2013, 308 ER-positive HER2-negative were assessed. results multivariate Cox analysis demonstrated that a high significantly associated short recurrence-free interval (RFI)...
Background The formation and/or maturation of adult organs in vertebrates often takes place during postembryonic development, a period around birth mammals when thyroid hormone (T3) levels are high. T3-dependent anuran metamorphosis serves as model to study development. Studies on the remodeling intestine Xenopus (X.) laevis have shown that development involves de novo stem cells process controlled by T3. On other hand, X. tropicalis, highly related laevis, offers number advantages for...
Abstract Background Near-infrared optical imaging targeting the intrinsic contrast of tissue hemoglobin has emerged as a promising approach for visualization vascularity in cancer research. We evaluated usefulness diffuse spectroscopy using time-resolved spectroscopic (TRS) measurements functional primary breast cancer. Methods Fifty-five consecutive TNM stageI/II patients with histologically proven invasive ductal carcinoma and operable tumors (<5 cm) who underwent TRS were enrolled....
Abstract Background: Brain metastases (BM) occur in 20%-50% of patients (pts) with HER2-positive (HER2+) metastatic breast cancer (MBC), and their presence is a poor prognostic factor. Leptomeningeal carcinomatosis (LMC) occurs 12%–43% pts MBC. Therapeutic options for BC BM and/or LMC are limited. Results the DESTINY-Breast01 DESTINY-Breast03 studies have shown clinical benefit trastuzumab deruxtecan (T-DXd) HER2+ MBC stable BM; however, study populations were small did not include active...