A5032242203- Adipokines, Inflammation, and Metabolic Diseases
- Cancer Genomics and Diagnostics
- Adipose Tissue and Metabolism
- Single-cell and spatial transcriptomics
- Mass Spectrometry Techniques and Applications
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Neurogenesis and neuroplasticity mechanisms
- Lipid metabolism and biosynthesis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Animal Behavior and Reproduction
- Evolution and Genetic Dynamics
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Immune Cell Function and Interaction
Washington University in St. Louis
2020-2025
St. Olaf College
2018
University of Missouri–St. Louis
2014
Soybean seeds are an important source of vegetable oil and biomaterials. The content individual triacylglycerol species (TAG) in soybean is difficult to quantify accurate rapid way. present study establishes approach TAG utilizing electrospray ionization tandem mass spectrometry with multiple neutral loss scans. Ten scans were performed detect the fatty acyl chains TAG, including palmitic (P, 16:0), linolenic (Ln, 18:3), linoleic (L, 18:2), oleic (O, 18:1), stearic (S, 18:0), eicosadienoic...
Targeting tumor-associated macrophages through C-C chemokine receptor type 2 (CCRs) in pancreatic ductal adenocarcinoma (PDAC) improves the efficacy of chemotherapy and restores T cell immunity preclinical models. We conducted a phase I/II single institution study (NCT03496662) combining gemcitabine nab-paclitaxel (GnP), CCR2/5 inhibitor BMS-813160 nivolumab for four 28-day cycles patients with borderline resectable (BR) or locally advanced (LA) PDAC. The recommended dose (RP2D) was...
Spatial structure has been shown to favor female-biased sex allocation, but current theory fails explain male biases seen in many taxa, particularly those with environmental determination (ESD). We present a and accompanying individual-based simulation model that demonstrates how population leads male-biased ratios under ESD. Our simulations agree earlier work showing the high productivity of female-producing habitats creates net influx sex-determining alleles into male-producing habitats,...
White adipose tissue is crucial in various physiological processes. In response to high caloric intake, may expand by generating new adipocytes. Adipocyte precursor cells (progenitors and preadipocytes) are essential for mature adipocytes, single-cell RNA sequencing provides means identify these populations. Here, we characterized adipocyte populations the skin, an depot with rapid robust generation of We identified a population immature preadipocytes, revealed biased differentiation...