A5080901819- CRISPR and Genetic Engineering
- Bacteriophages and microbial interactions
- Aquaculture disease management and microbiota
- Computational Drug Discovery Methods
- Parasitic Diseases Research and Treatment
- Viral gastroenteritis research and epidemiology
- Traditional and Medicinal Uses of Annonaceae
- thermodynamics and calorimetric analyses
- Insect symbiosis and bacterial influences
- Bacterial Genetics and Biotechnology
- Parasites and Host Interactions
- Piperaceae Chemical and Biological Studies
- Respiratory viral infections research
- Advanced biosensing and bioanalysis techniques
- Mosquito-borne diseases and control
- Chemistry and Chemical Engineering
- Diverse Scientific Research Studies
- Neurobiology and Insect Physiology Research
- Diatoms and Algae Research
- Chromosomal and Genetic Variations
- SARS-CoV-2 and COVID-19 Research
- Cephalopods and Marine Biology
- Plant Virus Research Studies
- RNA and protein synthesis mechanisms
- Vibrio bacteria research studies
University of Zulia
2020-2024
Thomas Jefferson University
2020
Abstract The global pandemic caused by infections of the new coronavirus (COVID-19) makes it necessary to find possible less toxic and easily accessible therapeutic agents. In this study, we used strategies docking molecular dynamics analyze phytochemical compounds against FDA-approved antimalarial drugs recommended for treatment COVID-19. evaluation was performed with scores MolDock Score Rerank calculated Molegro Molecular. DockThor server generate complexes myPresto dynamic studies....
The global pandemic caused by the new SARS-COV-2 coronavirus makes it necessary to search for drugs its control. Within of this research has been known that ivermectin drug, a FDA-approved which is formulated as an 80:20 mixture B1a and B1b used commonly parasitic infections, inhibitory effect on viruses, includes at in vitro level. In particular case mechanism action remains elusive controversial. Interestingly, energy interaction with any proteins SARS-CoV-2 possible structural alterations...
The pandemic caused by SARS-CoV-2 forces drug research to combat it. Ivermectin, an FDA approved antiparasitic formulated as a mixture 80:20 of the equipotent homologous 22,23 dihydro ivermectin (B1_a and B1_b), which is known inhibit in vitro with mechanism action be defined. It draws attention powerfully that energetic structural perturbation this induces binding on SARS-COV-2 proteins importance for its proliferation ill unknown. Hence what we do exhaustive computational biophysics study...
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs), together with cas genes, constitute the systems CRISPR-Cas, a novel type of innate defense system in prokaryotes for destruction exogenous elements (plasmids or phages). The genus Vibrio and Photobacterium represents one main responsible infectious agents aquaculture cause huge losses shrimp industry. few bioinformatic investigations on CRISPR/Cas Vibrionaceae family are mainly oriented to clinical species. Therefore,...
The clustered regularly interspaced short palindromic repeats (CRISPR) are genetic sequences that conventionally confer immunity to prokaryotes against invading elements. objective of this work was perform an analysis these at the thermodynamic level, determining minimum free formation energy (MFE) direct (DR) and complete CRISPR structures include spacer (DRSP), analyze possible relationship between energetics associated non-canonical mechanism in 30 prokaryotic reported genomes, understand...
In shrimp farming, the family of proteobacteria Vibrionaceae, especially species genus Vibrio, represent one main responsible for infections in production (Litopenaeus vannamei), generating great losses to this industry. Phagotherapy emerges as a novel alternative control said substitution use antibiotics, thanks specific inhibitory activity these viruses. However, it is necessary take into account presence prokaryotes genetic sequences called clusters regularly interspaced short palindromic...
Black Sigatoka, caused by the fungus Pseudocercospora fijiensis (Mycosphaerella fijiensis) is an important disease of bananas and plantain. The design sgRNAs molecules for gene silencing offers possible control this phytopathogen. sgRNAs, are that bind to enzymes specifically edit genes interest. use these requires bioinformatics tools their study. Therefore, objective research was characterize silence Fus3 virulence CYP51 growth in P. fijiensis, through analysis structural, thermodynamic...
The CRISPR-Cas9 technology used in plant biotechnology is based on the use of Cas9 endonucleases to generate precise cuts genome, and a duplex consisting trans-activating CRISPR RNA (tracrRNA) (DRRNA) which are precursors guide (sgRNA) commercially redesigned (sgRNA-Cas9) gene cleavage. Most these tools come from clinical bacteria. However, there several systems environmental microorganisms such as phytoendosymbionts plants genus Acholeplasma. But exploitation more compatible with requires...