A5115603786- Hepatocellular Carcinoma Treatment and Prognosis
- Ureteral procedures and complications
- Scoliosis diagnosis and treatment
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Metastasis and carcinoma case studies
- Vascular anomalies and interventions
- Acute Myeloid Leukemia Research
- Immunotherapy and Immune Responses
- Infection Control and Ventilation
- Cancer Research and Treatments
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Spondyloarthritis Studies and Treatments
- Ferroptosis and cancer prognosis
- Renal and Vascular Pathologies
- Neuroblastoma Research and Treatments
- Eicosanoids and Hypertension Pharmacology
- Spine and Intervertebral Disc Pathology
- COVID-19 and healthcare impacts
- Renal cell carcinoma treatment
- Genetic factors in colorectal cancer
- Renin-Angiotensin System Studies
- Epigenetics and DNA Methylation
Peking Union Medical College Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
National Cancer Institute
2023
Center for Cancer Research
2023
Harbin Medical University
2020-2023
Second Affiliated Hospital of Guangzhou Medical University
2023
Guangzhou Medical University
2023
Frederick National Laboratory for Cancer Research
2023
Nagoya University
2020
First Affiliated Hospital Zhejiang University
2019
Triple-negative breast carcinoma (TNBC) is one of the most aggressive types solid-organ cancers. While immune checkpoint blockade (ICB) therapy has significantly improved outcomes in certain cancers, patients with immunologically cold TNBC are afforded only a modest gain survival by addition ICB to systemic chemotherapy. Thus, it urgently needed develop novel effective therapeutic approaches for TNBC. Utilizing 4T1 murine model TNBC, we developed combination immunotherapeutic regimen...
The limited response to immune checkpoint blockades (ICBs) in patients with hepatocellular carcinoma (HCC) highlights the urgent need for broadening scope of current immunotherapy approaches. Lenvatinib has been shown a potential synergistic effect ICBs. This study investigated optimal method combining these two therapeutic agents and underlying mechanisms. lenvatinib at three different doses on promoting tissue perfusion vascular normalization was evaluated both immunodeficient...
The osteotomy surgery for ankylosing spondylitis (AS) presents a higher risk of dural injury and cerebrospinal fluid leakage compared to conventional spinal surgical procedures. However, there is currently lack systematic summaries in this field. This study aims present the incidence factors associated with tears (CSF) during corrective procedures AS kyphotic deformity. A retrospective analysis was conducted on patients diagnosed our hospital between June 2014 May 2024 who presented...
To determine whether short-term consumption of a moderately high-fat diet (MHFD) affects nitric oxide (NO) production, the concentration stable NO metabolites (NOx) in urine and plasma rats fed MHFD (15.6 %g fat) or control (4.5 was measured weekly for 4 weeks. Plasma NOx levels were significantly depressed group by week 1 remained so duration study. Decreased bioavailability may result from decrease production scavenging reactive oxygen species (ROS). Because endothelial NOS (eNOS) is major...
Abstract Neuroblastoma, a type of cancer that is common in children, composed two genetically clonal but epigenetically distinct cell types: mesenchymal (MES) and adrenergic (ADRN) types, controlled by super‐enhancer‐associated lineage‐specific transcription factor networks. Mesenchymal‐type cells are more migratory, resistant to chemotherapy, prevalent relapse tumors. Importantly, both types spontaneously transdifferentiate into one another, this interconversion can be induced genetic...
Urinary tract involvement through deep infiltrating endometriosis (DIE) is rare. The surgical management of DIE involving the ureter a complex procedure that requires an accurate balance between need for complete excision endometriotic foci and to avoid any morbidity associated with radical surgery. We reported patient ureteral (UE) complicated hydronephrosis who underwent right double-J stent insertion plus laparoscopic dissociation resection. Postoperative imaging examination suggested had...
Abstract Background To evaluate and compare the safety, efficacy cost of endoscopic submucosal snaring with circumferential mucosal incision (ESS-CMI) dissection (ESD) in various types colonic neoplasms. Methods Patients who were admitted our center for neoplasm therapy screened, Chinese item “endoscopic dissection” English abbreviation ESD, period between January 2011 December 2017. Initially enrolled patients further categorized into ESD ESS-CMI groups after careful assessment detailed...
Background: Breakthroughs have been made in cancer immunotherapy using antibodies against immune checkpoints. But successful checkpoint blockade (ICB) responses only occur a fraction of people, and we no idea which patients will be the lucky one before treatment. Picking out effective population accurately can improve cure rate significantly. We set to design novel immunophenotyping approaches for kidney renal clear cell carcinoma (KIRC) based on tumor microenvironment(TIME), target...