Deep learning has dramatically improved object recognition, speech medical image analysis and many other fields.Optical coherence tomography (OCT) become a standard of care imaging modality for ophthalmology.We asked whether deep could be used to segment cornea OCT images.Using custom-built ultrahigh-resolution system, we scanned 72 healthy eyes 70 keratoconic eyes.In total, 20,160 images were labeled the training in supervised approach.A custom neural network architecture called CorneaNet...

Dry eye disease (DED) is a highly prevalent ocular condition with significant burden on affected patients. Regardless of the underlying etiology, DED associated increased surface inflammation. We investigated safety and efficacy short-term treatment topical low dose hydrocortisone in patients chronic A total 60 (mean age 51 ± 14 years) conjunctival hyperemia greater than grade 2 Efron scale were included. Patients randomized to receive either preservative-free 0.335% (Softacort, Laboratories...

Purpose: The aim of this mechanistic clinical study was to explore the effect water-free perfluorohexyloctane eye drops on tear film thickness (TFT) in patients with dry disease (DED). Methods: Forty-eight mild moderate DED participated randomized, single-masked, observer-blinded parallel group a 1:1 ratio receive either or unpreserved 0.9% saline solution (Hydrabak®, Thea, France) 4 times daily both eyes for weeks. A custom-built ultrahigh-resolution optical coherence tomography system used...

The tear meniscus contains most of the fluid and therefore is a good indicator for state film. Previously, we used custom-built optical coherence tomography (OCT) system to study lower by automatically segmenting image data with thresholding-based segmentation algorithm (TBSA). In this report, investigate whether results are suitable train neural network in order obtain similar or better shorter processing times. Considering class imbalance problem, compare two approaches, one directly...

Purpose: This study investigated the effect of single administration 2 different hyaluronic acid-based topical lubricants on tear film thickness (TFT) in patients with moderate-to-severe dry eye disease (DED). Methods: Sixty were randomized to receive drops containing unpreserved sodium hyaluronate, triglycerides, and phospholipids (HTP), hyaluronate (HA), or chloride (NaCl). TFT lipid layer (LLT) assessed before at defined time points after instillation a custom-built ultrahigh-resolution...

Many different parameters exist for the investigation of tear film dynamics. We present a new meniscus segmentation algorithm which automatically extracts area (TMA), height (TMH), depth (TMD) and radius (TMR) from UHR-OCT measurements apply it to data set including repeated ten healthy subjects. Mean values standard deviations are 0.0174 ± 0.007 mm2, 0.272 0.069 mm, 0.191 0.049 mm 0.309 0.123 TMA, TMH, TMD TMR, respectively. A significant correlation was found between all respective...

Abstract Photoreceptor function is impaired in many retinal diseases like age-related macular degeneration. Currently, assessment of the photoreceptor for early diagnosis and monitoring these either subjective, as visual field testing, requires contact with eye, electroretinography, or relies on research prototypes acquisition speeds unattained by conventional imaging systems. We developed an objective, noncontact method to monitor using a standard optical coherence tomography system. This...

A custom-built ultrahigh-resolution optical coherence tomography (UHR-OCT) system and fluorescein staining were employed for investigation of a scopolamine induced dry eye mouse model.Acquired data was used to evaluate common complementary findings the two modalities.Central corneal thickness as measured by UHR-OCT increased significantly over study period 24 hours, from 89.0 ± 3.57 µm 92.2 4.07 µm.Both techniques able show lesions with large range severity.Localized detected in 5% diffuse...

To determine the association between tear film thickness (TFT) as measured with ultra-high resolution optical coherence tomography (UHR-OCT) and signs symptoms of dry eye disease (DED).A total 450 eyes from 225 patients DED six different randomized clinical trials were included in this pooled analysis. In all subjects, TFT was a custom-built UHR-OCT system. Symptoms quantified using standardized Ocular Surface Disease Index (OSD)I questionnaire including break up time (TFBUT) Schirmer I test...

Abstract Intrinsic optical signals constitute a noninvasive biomarker promising the objective assessment of retinal photoreceptor function. We employed commercial coherence tomography (OCT) system and an OCT signal model for evaluation path length (OPL) changes in temporal outer retina five healthy subjects during light adaptation. Data were acquired at 30 time points, ambient long duration stimulation with white light, analyzed, employing based on sum seven Gaussian curves corresponding to...

Purpose: This prospective, randomized, observer-masked, parallel-group study aimed to compare the effect of topical azithromycin and oral doxycycline on tear film thickness (TFT) signs symptoms ocular surface disease (OSD) in patients with meibomian gland dysfunction (MGD). Methods: Patients were randomized either receive or doxycycline. After a baseline visit, three follow-up visits at intervals 2 weeks scheduled. Main outcome was change TFT as measured ultrahigh resolution optical...

<h3>Background</h3> Interleukin 20 (IL-20) and its receptors are present in rheumatoid arthritis (RA) synovial tissue IL-20 is thought to play a role the pathophysiology of RA as proinflammatory cytokine. NNC0109-0012 (Anti-IL-20) novel human monoclonal IgG4 antibody which targets neutralises IL-20. Currently, being developed for treatment patients with RA. <h3>Objectives</h3> The primary objective this phase 1 trial was assess safety tolerability one dose per week seven consecutive weekly...

During wound healing, the rapid re-establishment of a functional microcirculation in wounded tissue is utmost importance. We applied optical coherence tomography (OCT) angiography to evaluate vascular remodeling an excisional model pinnae C57BL/6 and db/db mice receiving different proangiogenic topical treatments. Analysis high-resolution OCT angiograms, including four quantitative parameters vessel density, length, number bifurcations, tortuosity, revealed changes microvasculature allowed...

Abstract We trained a deep learning algorithm to use skin optical coherence tomography (OCT) angiograms differentiate between healthy and type 2 diabetic mice. OCT were acquired with custom‐built system based on an akinetic swept laser at 1322 nm lateral resolution of ∼13 μm using split‐spectrum amplitude decorrelation. Our data set consisted 24 stitched the full ear, size approximately 8.2 × mm, evenly distributed The classification uses ResNet v2 convolutional neural network architecture...

Purpose: The purpose of this study was to investigate rod photopigment bleaching-driven intrinsic optical signals (IOS) in the human outer retina and its measurement repeatability based on a commercial coherence tomography (OCT) platform. Methods: path length photoreceptor subretinal space (SRS), that is, distance between signal bands segment tips retinal pigment epithelium, measured 15 healthy subjects ambient light during long-duration bleaching white-light exposure. Results: On 2...

The purpose of this study was to investigate the correlation between pattern optical coherence tomography (OCT) en face maps tear film lipid layer (TFLL) and thickness (LLT), fluorescein breakup time (FBUT), Schirmer I test values in healthy subjects.Measurements from four clinical data sets were retrospectively analyzed, TFLL patterns classified into 3 categories: homogeneous (HOM), wavy (WAV), or dotted (DOT) appearance. Linear mixed model analyses performed. Intraclass coefficients index...

Abstract Purpose Dry Eye Disease (DED) has been found to be associated with reduced pre‐corneal tear film thickness (TFT). Previous studies have shown that topical lubricants the potential increase TFT in patients DED. In present study, we investigated whether anti‐inflammatory therapy low dose preservative free (PF) soft steroid, hydrocortisone 0.335% eye drops also an effect on moderate severe Methods A total of 60 DED were included. Patients randomized receive either for 12 days 4 times...