A5016984693- RNA modifications and cancer
- Head and Neck Cancer Studies
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Histone Deacetylase Inhibitors Research
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Microtubule and mitosis dynamics
- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Chemical Synthesis and Analysis
- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Medicinal Plants and Neuroprotection
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bioinformatics and Genomic Networks
Kyung Hee University Medical Center
2021-2025
Korea University
2010-2024
Korea Institute of Radiological and Medical Sciences
2010-2023
Kyung Hee University
2019
Sungkyunkwan University
2014-2017
Samsung Medical Center
2014-2017
Keimyung University
2017
Rural Development Administration
2009-2011
Abstract Cancer immunotherapy has emerged as a promising cancer treatment. However, the presence of immune-refractory tumor cells limits its clinical success by blocking amplification anti-tumor immunity. Previously, we found that immune selection drives evolution tumors toward multi-modal resistant and stem-like phenotypes via transcription induction AKT co-activator TCL1A NANOG. Here, report crucial role HSP90A at crossroads between NANOG-TCL1A axis multi-aggressive properties...
Abstract Cancer immunoediting drives the adaptation of tumor cells to host immune surveillance. Immunoediting driven by antigen (Ag)-specific T enriches NANOG expression in cells, resulting a stem-like phenotype and resistance. Here, we identify HDAC1 as key mediator NANOG-associated phenotype. upregulated through promoter occupancy, thereby decreasing histone H3 acetylation on K14 K27. NANOG-dependent, HDAC1-driven epigenetic silencing cell-cycle inhibitors CDKN2D CDKN1B induced features....
Immune selection drives tumor cells to acquire refractory phenotypes. We previously demonstrated that cytotoxic T lymphocyte (CTL)-mediated immune pressure enriches NANOG
The host immune system plays a pivotal role in the emergence of tumor cells that are refractory to multiple clinical interventions including immunotherapy, chemotherapy, and radiotherapy. Here, we examined molecular mechanisms by which triggers cross-resistance these interventions. By examining biological changes murine subjected sequential rounds vitro or vivo selection via cognate cytotoxic T lymphocytes, found multimodality resistance arises through core metabolic reprogramming pathway...
Immunoediting caused by antitumor immunity drives tumor cells to acquire refractory phenotypes. We demonstrated previously that antigen-specific T edit these such they become resistant CTL killing and enrich NANOGhigh cancer stem cell-like cells. In this study, we show synaptonemal complex protein 3 (SCP3), a member of the Cor1 family, is overexpressed in immunoedited upregulates NANOG hyperactivating cyclin D1-CDK4/6 axis. The SCP3-cyclin axis was preserved across various types human...
Abstract Background Under conditions of hypoxia, cancer cells with hypoxia inducible factor-1α (HIF-1α) from heterogeneous tumor show greater aggression and progression in an effort to compensate for harsh environmental conditions. Extensive study on the stability HIF-1α under acute has been conducted, however, understanding its involvement during chronic phase is limited. Methods In this study, we investigated effect SIRT1 HIF1 a typical hypoxic conditon that maintains 24 h using Western...
<title>Abstract</title> Cancer immunotherapies, including immune checkpoint blockade (ICB), have marked a significant breakthrough in cancer treatment but their clinical efficacy is limited immune-resistant tumors. Previously, we found that immunotherapy-mediated selection enriches tumors with both tumor-intrinsic and -extrinsic refractory phenotypes via the transcriptional induction of HDAC1 by NANOG. Here, identify CRY1 as critical target NANOG stabilizes Cyclin A MCL1 to promote stem...
Abstract Immune selection drives the evolution of tumor cells toward an immune-resistant and cancer stem cell (CSC)-like phenotype. We reported that apoptosis inhibitor-5 (API5) acts as immune escape factor, which has a significant role in controlling resistance to antigen-specific T cells, but its functional association with CSC-like properties remains largely unknown. In this study, we demonstrated for first time API5 confers properties, including NANOG expression, frequency CD44-positive...
Rab escort protein 1 (REP1) is a component of geranyl-geranyl transferase 2 complex. Mutations in REP1 cause disease called choroideremia (CHM), which an X-linked eye disease. Although it postulated that has functions cell survival or death various tissues addition to the eye, how normal and cancer cells remains be elucidated. Here, we demonstrated required for intestinal eyes variety zebrafish, also important roles tumorigenesis. Notably, highly expressed colon lines, silencing sensitizes...
Most tumors frequently undergo initial treatment with a chemotherapeutic agent but ultimately develop resistance, which limits the success of chemotherapies. As cisplatin exerts high therapeutic effect in variety cancer types, it is often used diverse strategies, such as neoadjuvant, adjuvant and combination However, resistance has manifested regardless type, represents an unmet clinical need. Since we found that API5 expression was positively correlated chemotherapy several specimens from...
Gastric adenocarcinoma (GAC) is a lethal disease characterized by genomic and clinical heterogeneity. By integrating 8 previously established signatures for GAC subtypes, we identified 6 clinically molecularly distinct consensus subtypes (CGSs). CGS1 have the poorest prognosis, very high stem cell characteristics, IGF1 expression, but low alterations. CGS2 enriched with canonical epithelial gene expression. CGS3 CGS4 copy number alterations immune reactivity. However, differ in that has HER2...
Standard treatment for glioblastoma comprises surgical resection, chemotherapy with temozolomide, and radiotherapy. Nevertheless, majority of patients have recurrence from resistance to the cytotoxic conventional therapies. We examined combinational effects KML001, an arsenic compound targeting telomeres chromosomes temozolomide or irradiation, in cell lines xenograft models, overcome therapeutic limitation chemoradiation therapy glioblastoma. Although KML001 alone showed little on vitro...
Glioblastoma multiforme (GBM) is the most malignant World Health Organization grade IV brain tumor. GBM patients have a poor prognosis because of its resistance to standard therapies, such as chemotherapy and radiation. Since stem-like cells been associated with treatment GBM, novel therapies targeting cancer stem cell (CSC) population critically required. However, CSCs share molecular functional characteristics normal neural (NSCs). To elucidate differential therapeutic targets CSCs, we...
Background: We propose a novel prognostic biomarker-based strategy for increasing the efficacy of radiotherapy (RT) in head and neck squamous cell carcinoma (HNSCC). Materials Methods: identified genes associated with superoxide dismutase 2 (SOD2) nuclear factor erythroid-2-related (NRF2) from gene-expression data The Cancer Genome Atlas (TCGA) by calculating Pearson correlation. Patients were divided into two groups using hierarchical clustering. Colony-formation assay was performed to...
The promoter region of the telomerase reverse transcriptase gene (TERT) is mutated in a subpopulation patients with glioblastoma multiforme (GBM). In present study, preclinical and clinical implications mutation were analyzed 25 GBMs to evaluate its utility as therapeutic target. Associations between TERT number preclinical/clinical characteristics analyzed. Notably, was identified 92.3% where dissociated cells revealed vitro sphere formation capacity; while 33.3% without capacity (P=0.004)....
The FAT1 gene functions as a tumor suppressor or promoter and remains incompletely understood. We examined the clinical significance of in head neck squamous cell carcinoma (HNSCC) using four publicly available HNSCC cohorts one cohort enrolled at tertiary medical center. developed signatures reflecting mutations mRNA expression cohort. Patients with were classified into ‐associated low risk (FAT1‐LR; n = 195) high (FAT1‐HR; 371) subgroups. five‐year overall survival recurrence‐free rates...
Although numerous studies have used systemic approaches to identify prognostic predictors in oral squamous cell carcinoma (OSCC), the effectiveness of these has not been assessed clinically. Further, mechanism underlying malignant behaviors OSCC is poorly characterized. This study aimed develop and verify accurate for patients assess associated biology. We identified an OSCC-recurrence-related gene signature (ORGS) using a Cox regression analysis. Functional enrichment analysis was enriched...
Abstract Background Various cancer stem cell (CSC) biomarkers and the genes encoding them in head neck squamous carcinoma (HNSCC) have been identified evaluated. However, validity of these factors prognosis HNSCC has questioned remains unclear. In this study, we examined clinical significance CSC biomarker HNSCC, using five publicly available cohorts. Methods To predict patients with developed validated expression signatures whose mRNA levels correlated at least one four ( CD44 , MET ALDH1A1...