A5100897931- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Ion-surface interactions and analysis
- Iron Metabolism and Disorders
- Electron and X-Ray Spectroscopy Techniques
- Advanced Electron Microscopy Techniques and Applications
- Cultural Heritage Materials Analysis
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced Fluorescence Microscopy Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- X-ray Spectroscopy and Fluorescence Analysis
- Antioxidant Activity and Oxidative Stress
- Lipoproteins and Cardiovascular Health
- Selenium in Biological Systems
- Whipple's Disease and Interleukins
- Alzheimer's disease research and treatments
- Pregnancy and preeclampsia studies
- Cerebrovascular and Carotid Artery Diseases
- Microstructure and mechanical properties
- MRI in cancer diagnosis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Metallic Glasses and Amorphous Alloys
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
National University of Singapore
2003-2023
Chinese Academy of Sciences
1995
Institute of High Energy Physics
1995
As the inflammatory enzyme myeloperoxidase (MPO) is abundant in ruptured human atherosclerotic plaques, we aimed to investigate role of MPO as a potential diagnostic and therapeutic target for high-risk plaque.We employed tandem stenosis model plaque instability apolipoprotein E gene knockout (Apoe-/-) mice. To test MPO, used Mpo-/-Apoe-/- mice 2-thioxanthine inhibitor AZM198. In vivo activity was assessed by liquid chromatography-tandem mass spectrometry detection 2-chloroethidium...
Vascular smooth muscle cells (VSMCs) contribute dynamically to atherosclerosis at all stages but the molecular drivers of their phenotypic switching, especially during early plaque development, and how they progression remain unclear. We performed spatial transcriptomics on 12 human aortic tissues with without atherosclerotic plaque. Macrophage-like SMCs were predominant cell-type in atheroma, displaying high iron storage dysregulation, confirmed by elemental mapping nuclear microscopy. The...
The uptake of rare earth elements (REEs) such as Nd 3+ , Gd and Er by Euglena gracilis 848 algae cells has been studied using nuclear microprobe techniques at the Centre for Ion Beam Applications (CIBA), National University Singapore. cell imaging facility recently constructed CIBA allows scanning transmission ion microscopy (STIM) down to sub‐100‐nm level provides energy loss images whole intact cells. Helical coiling pellicle strips was observed, Rutherford backscattering spectrometry...
Changsha kiln ware represents an important status in the history of Chinese ceramics, well-known for its massive production capacity evidenced from extensive archaeological finds both domestically and abroad. It is long known or assumed that pioneer underglaze painted porcelains, however recent analytical studies suggest otherwise: overglaze, atypical underglaze, cannot be ascertained microscopically. glazing technique remains a convoluted issue debatable amongst scholars yet to concluded....
Abstract All clinically-approved and many novel gadolinium (Gd)-based contrast agents used to enhance signal intensity in magnetic resonance imaging (MRI) are optically silent. To verify MRI results, a “gold standard” that can map quantify Gd down the parts per million (ppm) levels is required. Nuclear microscopy relatively new technique has this capability composed of combination three ion beam techniques: scanning transmission microscopy, Rutherford backscattering spectrometry, particle...
Changsha kiln ware represents an important status in the history of Chinese ceramics, well-known for its massive production capacity evidenced from extensive archaeological finds both domestically and abroad. It is long known or assumed that pioneer underglaze painted porcelains, however recent analytical studies suggest otherwise: overglaze, atypical cannot be ascertained microscopically. glazing technique remains a convoluted issue debatable amongst scholars yet to concluded. To...