A5057628003- Chronic Lymphocytic Leukemia Research
- Glycosylation and Glycoproteins Research
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Phagocytosis and Immune Regulation
- Galectins and Cancer Biology
- Micro and Nano Robotics
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- Slime Mold and Myxomycetes Research
- Biocrusts and Microbial Ecology
- Cell death mechanisms and regulation
- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- RNA and protein synthesis mechanisms
- Hippo pathway signaling and YAP/TAZ
- Folate and B Vitamins Research
- Cell Adhesion Molecules Research
- Spaceflight effects on biology
- Glioma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Cancer, Lipids, and Metabolism
- Cellular transport and secretion
- Molecular Communication and Nanonetworks
Universitat de les Illes Balears
2023
IFOM
2015-2018
University of Milan
2017-2018
Centre de Recherche en Cancérologie de Toulouse
2013
Centre National de la Recherche Scientifique
2012-2013
Université Toulouse III - Paul Sabatier
2012-2013
Inserm
2012-2013
Centre de Physiopathologie de Toulouse-Purpan
2012-2013
Universitat de València
1999-2005
Frustration due to differences in cell motility within clusters gives rise novel collective motion of migrating clusters.
Abstract How cells move chemotactically remains a major unmet challenge in cell biology. Emerging evidence indicates that for interpreting noisy, shallow gradients of soluble cues system must behave as an excitable process. Here, through RNAi-based, high-content screening approach, we identify RAB35 necessary the formation growth factors (GFs)-induced waves circular dorsal ruffles (CDRs), apically restricted actin-rich migratory protrusions. is sufficient to induce recurrent and polarized...
T-cell scanning for antigen-presenting cells (APC) is a finely tuned process. Whereas non-cognate APC trigger motility via chemokines and intercellular adhesion molecule-1 (ICAM-1), cognate deliver stop signal resulting from antigen recognition. We tested in vitro the contribution of actin cytoskeleton regulator Wiskott-Aldrich syndrome protein (WASP) to activity primary human CD4(+) T cells. WASP knock-down resulted increased upon encounter with dendritic or B reduced capacity following The...
Abstract Solid tumor dissemination relies on the reprogramming of molecular pathways controlling chemotaxis. Whether motility nonsolid tumors such as leukemia depends deregulated expression molecules decoding chemotactic signals remains an open question. We identify here membrane remodeling F-BAR adapter protein Cdc42-interacting 4 (CIP4) a key regulator chemotaxis in chronic lymphocytic (CLL). CIP4 is expressed at abnormally high levels CLL cells, where it required for CCL19-induced Upon...
Click to increase image sizeClick decrease sizeKeywords: Free radicalsglutathionelipid peroxidationantioxidants
<p>AVI file - 1602K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections the lamellipodium a representative JVM3 cell expressing GFP-CIP4 and migrating in CCL19 gradient. The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>AVI file - 2141K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections the lamellipodium a representative JVM3 cell expressing GFP-CIP4 and migrating in CCL19 gradient. The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>PDF file - 74K</p>
<p>PDF file - 54K, Additional information regarding CCR7 internalization.</p>
<p>AVI file - 1553K, Time-lapse video-recording of a representative JVM3 cell expressing GFP-actin and migrating in CCL19 gradient (source towards the bottom).</p>
<p>AVI file - 1134K, Time-lapse video-recording of a representative CIP4 knocked-down JVM3 cells exposed to CCL19 gradient (source towards the bottom) over period 12 min.</p>
<p>AVI file - 3816K, Time-lapse video-recording of a representative JVM3 cell expressing GFP-CIP4 and migrating over period 37 min in CCL19 gradient (source towards the bottom). The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>AVI file - 2015K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections the lamellipodium a representative JVM3 cell expressing GFP-CIP4 and migrating in CCL19 gradient. The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>AVI file - 1602K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections the lamellipodium a representative JVM3 cell expressing GFP-CIP4 and migrating in CCL19 gradient. The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>AVI file - 1134K, Time-lapse video-recording of a representative CIP4 knocked-down JVM3 cells exposed to CCL19 gradient (source towards the bottom) over period 12 min.</p>
<p>AVI file - 2015K, Supplemental Movies 6-8 shows Time-lapse video-recording of zoomed sections the lamellipodium a representative JVM3 cell expressing GFP-CIP4 and migrating in CCL19 gradient. The four panels show (green), pseudo-colour scale indicating CIP4 level, transmission merge.</p>
<p>AVI file - 4312K, Time-lapse video-recording of a representative JVM3 cell expressing GFP-CCR7 distribution and migrating in CCL19 gradient (source towards the bottom).</p>
<p>AVI file - 503K, Time-lapse video-recording of a representative JVM3 cells exposed to CCL19 gradient (source towards the bottom) over period 5 min.</p>
<p>PDF file - 74K</p>