A5070835958- Animal Genetics and Reproduction
- Hematopoietic Stem Cell Transplantation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Cell Function and Interaction
- Single-cell and spatial transcriptomics
- Cancer Genomics and Diagnostics
- Clinical Nutrition and Gastroenterology
- Animal Vocal Communication and Behavior
- Chromosomal and Genetic Variations
- T-cell and B-cell Immunology
- Pancreatic and Hepatic Oncology Research
- Avian ecology and behavior
- Gastrointestinal motility and disorders
- Insect and Arachnid Ecology and Behavior
- Cytomegalovirus and herpesvirus research
Columbia University Irving Medical Center
2020-2024
Rockefeller University
2023-2024
1 Abstract Primordial germ cells (PGCs) are germline stem that develop into sperm or egg and valuable for avian biobanking the propagation of donor-derived offspring. However, in non-poultry birds long-term maintenance self-renewal PGCs vitro remains challenging. This limitation hinders other clades, particularly zebra finch songbirds uniquely possess a restricted chromosome (GRC). Here, we generated compared short-term cultures chicken from embryonic gonads blood, as well established PGCs....
Allogeneic hematopoietic cell transplantation (alloHCT) is curative for various hematologic diseases but often leads to acute graft-versus-host disease (GVHD), a potentially life-threatening complication. We leverage GVHD as uniquely tractable model dissect complex T-cell-mediated pathology in 27 alloHCT recipients. integrate pre-transplant identification of alloreactive T-cells with longitudinal tracking across blood and gut, using mixed lymphocyte reaction-based clonal "fingerprinting",...
The diversity of germ cell developmental strategies has been well documented across many vertebrate clades. However, much our understanding avian primordial (PGC) specification and differentiation derived from only one species, the chicken (Gallus gallus). Of three major classes birds, chickens belong to Galloanserae, representing less than 4% while nearly 95% extant bird species Neoaves. This represents a significant gap in knowledge development hampering efforts adapt genome editing...