A5027914847- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Molecular Biology Techniques and Applications
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Lipid metabolism and biosynthesis
- Cell death mechanisms and regulation
- Polyamine Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- Microplastics and Plastic Pollution
- Protein Kinase Regulation and GTPase Signaling
- Dietary Effects on Health
- Recycling and Waste Management Techniques
- RNA regulation and disease
- Telomeres, Telomerase, and Senescence
- Papaya Research and Applications
- Apelin-related biomedical research
- Plant Genetic and Mutation Studies
- Synthesis and Biological Activity
- Effects and risks of endocrine disrupting chemicals
- Linguistics and Discourse Analysis
- Bioactive Compounds and Antitumor Agents
- Phytochemical compounds biological activities
- Folate and B Vitamins Research
Instituto Politécnico de Lisboa
2019-2024
National Institute of Health Dr. Ricardo Jorge
2015-2023
University of Lisbon
2017-2023
Gastric Cancer (GC) is one of the most prevalent cancers worldwide. As currently available therapeutic options are invasive, new and more benign being explored. One which Apigenin (Api), a natural flavonoid found in fruits vegetables, such as celery, parsley, garlic, bell pepper chamomile tea. Api has known anti-inflammatory, -oxidant, -proliferative proprieties several diseases its potential an anticancer compound been Here we systematize data regarding effects on GC cells, terms cell...
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that recognizes and selectively degrades mRNAs carrying premature termination codons (PTCs). The level of sensitivity PTC-containing to NMD multifactorial. We have previously shown human β-globin PTCs in close proximity the translation initiation AUG codon escape NMD. This was called 'AUG-proximity effect'. present analysis nonsense α-globin illustrates determinants AUG-proximity effect are fact quite complex, reflecting ability...
The mechanistic/mammalian target of rapamycin (mTOR) is a conserved serine/threonine kinase that integrates cellular signals from the nutrient and energy status to act, namely, on protein synthesis machinery. While major advances have emerged regarding regulators effects mTOR signaling pathway, little known about regulation gene expression. Here, we show human transcript can be translated in cap-independent manner, its 5′ untranslated region (UTR) highly folded RNA scaffold capable binding...
Abstract p53 is the most known and studied tumour suppressor gene. Yet we have recently shown that also a proto-oncogene, as it encodes Δ160p53 oncoprotein. Integrated stress response (ISR) survival pathway frequently activated in cancers, marked by phosphorylation of eukaryotic initiation factor 2alpha (eIF2α) defined reprogramming mRNA translation. Here identified ISR powerful trigger oncogene, leading to induction not only but Δ133p53, another protein variant Upon two isoforms were...
Introduction: The rapidly contagious process of respiratory viruses such as SARS-CoV-2 makes it urgent to multiply testing for diagnostics identify the active viral shedding cases (current infection, carriage state or, residual RNA) and decrease risk transmission other patients healthcare professionals. Although nasopharyngeal swabs (NPSs) are most common specimen type used COVID-19 diagnosis, they require supervision by a professional, concerns have been raised regarding personnel exposure,...
Obesity is a clinical condition characterized by an abnormal accumulation of adipose tissue with increased risk developing illnesses such as type 2 diabetes, cardiovascular disease, and cancer. In obesity, the secretion proinflammatory adipokines contributes to oxidative stress that can lead decline in length telomeres. Telomeres are structures repetitive sequences delimiting chromosomes, plays crucial role maintaining their integrity stability and, thus, its shortening associated cellular...