A5078268869- Retinal Imaging and Analysis
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Glaucoma and retinal disorders
- Telomeres, Telomerase, and Senescence
- Pluripotent Stem Cells Research
- Noise Effects and Management
- Retinal Development and Disorders
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Genetics, Bioinformatics, and Biomedical Research
- Renal and related cancers
- Nuclear Receptors and Signaling
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Physical Activity and Health
- Dye analysis and toxicity
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular and exercise physiology
- Heat shock proteins research
- RNA Interference and Gene Delivery
- Obesity, Physical Activity, Diet
Hunter Medical Research Institute
2023-2024
The University of Sydney
2011-2024
Children's Medical Research Institute
2013-2022
Institute of Bioinformatics
2021
Westmead Institute
2010-2013
Westmead Hospital
2011
Children's Hospital at Westmead
2011
Centre for Eye Research Australia
2011
The University of Melbourne
2011
Singapore National Eye Center
2011
Background: age-related hearing loss is a common chronic condition; hence, it important to understand its influence on the functional status of older adults. We assessed association between impairment with activity limitations as by activities daily living (ADL) scale.
Acquisition of replicative immortality is currently regarded as essential for malignant transformation. This achieved by activating a telomere lengthening mechanism (TLM), either telomerase or alternative telomeres, to counter normal attrition. However, substantial proportion some cancer types, including glioblastomas, liposarcomas, retinoblastomas, and osteosarcomas, are reportedly TLM-negative. As serial samples human tumors cannot usually be obtained monitor length changes, it has...
Abstract A primary haplotype (H1) of the microtubule‐associated protein Tau (MAPT) gene is associated with Parkinson's disease (PD). However, mechanism for susceptibility remains unknown. We examined promoter region MAPT and identified single nucleotide polymorphisms insertions 1 to 11 nucleotides. These corresponded previously characterized haplotypes, H1 H2, as well a novel variant haplotype, H1′. As observed in other studies, we demonstrated significant association H1/H1 genotype PD...
Advances in the study of neurological conditions have been possible because pluripotent stem cell technologies and organoids. Studies described generation neural ectoderm-derived retinal brain structures from cells. However, field is still troubled by technical challenges, including high culture costs variability. Here, we describe a simple economical protocol that reproducibly gives rise to retina cortical regions confluent cultures The spontaneously generated organoids are...
It is not clear whether physical activity and sedentary behavior affect retinal microvascular caliber. We investigated associations among (outdoor indoor sporting activities), behaviors (including screen time, television [TV] viewing, computer videogame usage), caliber in schoolchildren.Six-year-old students (1765/2238) from a random cluster sample of 34 Sydney schools were examined. Parents completed questionnaires about activities. Retinal images taken, vessel was quantified. After...
OBJECTIVES. In adults, obesity is linked to changes in the retinal microvasculature. Limited research has been conducted into this association children. We examined a cohort of pre-adolescents relationship between body mass index (BMI) and vascular structure, including vessel diameter fractals, measure geometric patterns reflecting density.A population-based study among school children (2 353/3 144 [75.3%], median age, 12.7 years) recruited from random cluster sample 21 schools was during...
The replicative immortality of human cancer cells is achieved by activation a telomere maintenance mechanism (TMM). To achieve this, utilise either the enzyme telomerase, or Alternative Lengthening Telomeres (ALT) pathway. These distinct molecular pathways are incompletely understood with respect to and propagation, as well their associations clinical outcomes. We have identified significant differences in repeat composition tumours that use ALT compared do not. then employed machine...
Few studies have examined the effect of blood pressure (BP) on retinal microvasculature in children. We relationship between BP and vessel caliber a sample preadolescent schoolchildren.Eligible high school students [2353/3144 (response 75.3%); mean age, 12.7 years] from 21 randomly selected schools Sydney, Australia, were during 2004-2005. Retinal was quantified digital images using well known computer-based programs. measured standard protocol defined according to published guidelines for...
The telomerase protein hTERT has a noncanonical role in promoting telomere protection by heat shock 70.
Abstract A proteomics approach was used to identify the proteins potentially implicated in cellular response concomitant with elevated production levels of human growth hormone a recombinant Chinese hamster ovary (CHO) cell line following exposure 0.5 m M butyrate and 80 μ zinc sulphate media. This involved incorporation two‐dimensional (2‐D) gel electrophoresis protein identification by combination N ‐terminal sequencing, matrix‐assisted laser desorption/ionisation‐time flight mass...
In the current study, we aimed to examine associations of low birth weight with retinal vascular caliber and fractal dimension during early adolescence.A population-based study 12-year-old schoolchildren (2353/3144 [75.3%]) recruited from a random cluster sample 21 schools. Birth weight, length head circumference were obtained via parent report child's record. Retinal images taken vessel diameter quantified using validated computer-based methods.After adjusting for age, sex, ethnicity, body...
Abstract Background Automated candidate gene prediction systems allow geneticists to hone in on disease genes more rapidly by identifying the most probable linked phenotypes under investigation. Here we assessed ability of eight different predict intervals previously associated with type 2 diabetes benchmarking their performance against implicated recent genome-wide association studies. Results Using a search space 9556 genes, all but one pruned genome favour moderate highly significant...
Cancers that utilize the Alternative Lengthening of Telomeres (ALT) mechanism for telomere maintenance are often difficult to treat and have a poor prognosis. They also commonly deficient expression ATRX protein, repressor ALT activity, component PML nuclear bodies (PML NBs) which required intrinsic immunity various viruses. Here we asked whether ATRX-deficiency creates vulnerability in cancer cells could be exploited therapeutic purposes. We showed range cell types mutant herpes simplex...
We aimed to assess the associations between parental history of hypertension and indicators cardiovascular risk (retinal vessel diameter, presence obesity, elevated blood pressure) in prepubertal children. There were 1739 (77.7% those eligible) 6-year-old students (863 girls 876 boys) who examined from a random cluster sample 34 Sydney schools. Parents completed questionnaires about their medical conditions, including whether they have/had hypertension. Retinal images taken with digital...