A5074953989- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Systemic Lupus Erythematosus Research
- Traumatic Ocular and Foreign Body Injuries
- Ocular Surface and Contact Lens
- Photoreceptor and optogenetics research
- Ocular Diseases and Behçet’s Syndrome
- Facial Trauma and Fracture Management
- Retinal and Optic Conditions
- Acne and Rosacea Treatments and Effects
- Intraocular Surgery and Lenses
- Neuroscience and Neural Engineering
- Contact Dermatitis and Allergies
- Agricultural safety and regulations
- Retinal and Macular Surgery
- Cerebral Venous Sinus Thrombosis
- Pesticide Exposure and Toxicity
- Neural Networks and Applications
- Advancements in Transdermal Drug Delivery
- Beetle Biology and Toxicology Studies
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Tuberous Sclerosis Complex Research
University of Iowa
2019-2024
University of Iowa Hospitals and Clinics
2019-2023
University of California, Davis
2008-2022
Massachusetts Eye and Ear Infirmary
2015
University of California, San Francisco
2008-2011
Purpose: To perform in vivo evaluation of the structural morphology and vascular plexuses neurosensory retina choroid across vertebrate species using swept-source optical coherence tomography (SS-OCT) SS-OCT angiography (SS-OCTA) imaging. Methods: A custom-built system with an incorporated flexible imaging arm was used to acquire three-dimensional (3D) retinal OCT OCTA data five different vertebrates: a mouse (C57BL/6J), rat (Long Evans), gray short-tailed opossum (Monodelphis domestica),...
BACKGROUND AND PURPOSE Soluble epoxide hydrolase inhibitors (sEHIs) possess anti‐inflammatory, antiatherosclerotic, antihypertensive and analgesic properties. The pharmacokinetics (PK) pharmacodynamics in terms of inhibitory potency sEHIs were assessed non‐human primates (NHPs). Development a sEHI for use NHPs will facilitate investigations on the role sEH numerous chronic inflammatory conditions. EXPERIMENTAL APPROACH PK parameters 11 cynomolgus monkeys determined after oral dosing with 0.3...
Diabetes mellitus is a multiorgan systemic disease impacting numerous ocular structures that results in significant morbidity and often more frequent corneal glaucoma surgeries for affected individuals. We hypothesize the metabolic proteomic derangement observed progression of diabetes influences composition aqueous humor (AH), which ultimately impacts anterior segment health eye. To identify changes associated with progression, we mapped metabolite profile proteome AH samples from patients...
Abstract Stargardt disease, the most common inherited macular dystrophy, is characterized by vision loss due to central retinal atrophy. Although clinical trials for are currently underway, disease typically slowly progressive, and objective, imaging-based biomarkers critically needed. In this retrospective, observational study, we characterize thicknesses of individual sublayers optical coherence tomography (OCT) in a large cohort patients with molecularly-confirmed, ABCA4 -associated...
Vertebrate retinal photoreceptors signal light by suppressing a circulating “dark current” that maintains their relative depolarization in the dark. This dark current is composed of an inward through CNG channels and NCKX transporters outer segment balanced outward exiting principally from inner segment. It has been hypothesized Kv2.1 carry predominant fraction rods. We examined this hypothesis comparing whole cell, suction electrode, electroretinographic recordings knockout (Kv2.1−/−)...
The temporal resolution of scotopic vision is thought to be constrained by the signaling kinetics retinal rods, which use a highly amplified G-protein cascade transduce absorbed photons into changes in membrane potential. Much known about biochemical mechanisms that determine rod responses ex vivo, but rate-limiting vivo are unknown. Using paired flash electroretinograms with improved signal-to-noise, we have recorded amplitude and wide range strengths from living mice. Bright recovered...
Abstract Many retinal diseases involve the loss of light-sensing photoreceptor cells (rods and cones) over time. The severity distribution varies widely across affected individuals, so characterizing degree pattern can clarify pathophysiology prognosis. Currently, in vivo visualization individual photoreceptors requires technology such as adaptive optics, which has numerous limitations is not used. By contrast, optical coherence tomography (OCT) nearly ubiquitous daily clinical practice...
Purpose: Guinea pig sensitization assays provide a critical tool in toxicological testing. Here, we investigate the relative sensitivities of Pig Maximization Test (GPMT), Open Epicutaneous (OET), and Buehler test on seven common compounds.Methods: Seven compounds (formalin, nickel sulfate, 2-benzothiazolethiol, neomycin potassium dichromate, ethylenediamine, dihydrochloride, cinnamyl alcohol) were investigated 15 guinea pigs per assay. Differences between each assay individually for...
Objective To correlate structural features seen on optical coherence tomography (OCT) with best-corrected visual acuity (BCVA) and Gass lesion type in patients Best vitelliform macular dystrophy (BVMD). Methods analysis This is a retrospective case series of consecutive molecularly confirmed BEST1- associated BVMD. OCT scans were reviewed for status presence subretinal pillar, focal choroidal excavation (FCE), intraretinal fluid or atrophy. Available angiography images used to evaluate the...
Burn patients receiving aggressive fluid resuscitation are at risk of developing orbital compartment syndrome (OCS). This condition results in elevated pressures and can lead to rapid permanent vision loss. Risk factors monitoring frequency for OCS remain largely unknown. A retrospective review was therefore conducted admitted burn evaluated by the ophthalmology service an American Association verified Treatment Center. Demographic, burn, examination, data were compared using two-sided...
Purpose Autoimmune retinopathy (AIR) is a poorly characterized disease with wide phenotypic spectrum, complicating investigations of its underlying pathophysiology. We sought to analyze optical coherence tomography (OCT) retinal thickness changes in AIR patients.Methods A retrospective chart review from 2007 2017 was performed evaluating patients at single academic, tertiary referral center. OCT sublayer analysis performed, and paradoxical thickening phenotypes were reviewed.Results...
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Purpose: Autoimmune retinopathy (AIR) is a poorly understood condition with wide phenotypic spectrum and heterogeneous findings on clinical examination imaging. In this study, the authors characterize features of recently described subtype AIR distinct split outer plexiform layer appearance OCT. Methods: This was retrospective, observational study patients diagnosis seen at University Iowa between January 2007 September 2023 who were found to have decreased visual acuity, central scotoma...
Purpose: To evaluate the efficacy of cooled vs room-temperature artificial tears in reducing ocular discomfort after intravitreal injections (IVIs). Methods: Patients receiving a standard injection retina clinic who met eligibility criteria and provided informed consented were enrolled study. randomized to or intervention group. Both groups rated their following IVI administered. Results: The group comprised 48 patients group, 61 patients. There was no significant difference reduction...
Purpose: The aim of this study was to define risks for corneal transplantation associated with fibrous ingrowth among first-time transplant recipients. Methods: We performed a retrospective case–control patients histopathologic diagnosis between 2002 and 2019. Patients from first specimen were included. Those incomplete records excluded. A 1:2 ratio used. Controls matched using surgical indication, surgery year, method, sex, age. Results: Seventy-eight eyes (76 patients) included 160 control...