A5033191674- Zebrafish Biomedical Research Applications
- Genomics and Phylogenetic Studies
- Phagocytosis and Immune Regulation
- Genomics and Rare Diseases
- Advanced biosensing and bioanalysis techniques
- Cell Adhesion Molecules Research
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- Genetic Associations and Epidemiology
- Genomics and Chromatin Dynamics
University of Michigan
2020-2024
Michigan United
2024
Understanding the functional effects of sequence variation is crucial in genomics. Individual human genomes contain millions variants that contribute to phenotypic variability and disease risks at population level. Because rarely act isolation, we must consider potential interactions neighboring accurately predict effects. We can accomplish this using haplotagging, which matches sequencing reads their parental haplotypes alleles observed known heterozygous variants. However, few published...
Understanding the functional effects of sequence variation is among primary goals contemporary genomics. Individual human genomes contain millions variants which are thought to contribute phenotypic variability and differential disease risks at population level. However, because rarely act in isolation, we cannot accurately predict without first considering potential other interacting on same chromosome. This information can be obtained by phasing read data from sequencing experiments. no...
Abstract Background Zebrafish are a foundational model organism for studying the spatio-temporal activity of genes and their regulatory sequences. A variety approaches currently available editing modifying gene expression in zebrafish, including RNAi, Cre/lox, CRISPR-Cas9. However, lac operator-repressor system, component E. coli operon which has been adapted use many other species is valuable, flexible tool inducible modulation expression, not previously tested zebrafish. Results Here we...
Zebrafish are a foundational model organism for studying the spatio-temporal activity of genes and their regulatory sequences. A variety approaches currently available editing modifying gene expression in zebrafish, including RNAi, Cre/lox, CRISPR-Cas9. However, lac operator-repressor system, an E. coli operon component which has been adapted use many other species is valuable, flexible tool inducible modulation studies, not previously tested zebrafish. Here we demonstrate that system...