A5012099600- Obstructive Sleep Apnea Research
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Voice and Speech Disorders
- Eosinophilic Esophagitis
- Parasites and Host Interactions
- Cystic Fibrosis Research Advances
- Lymphatic Disorders and Treatments
- Antibiotic Resistance in Bacteria
- Asthma and respiratory diseases
- Human Mobility and Location-Based Analysis
- Congenital Ear and Nasal Anomalies
- COVID-19 epidemiological studies
- IL-33, ST2, and ILC Pathways
- Dermatological diseases and infestations
- Muscle Physiology and Disorders
- Neurogenetic and Muscular Disorders Research
- Obsessive-Compulsive Spectrum Disorders
- Eosinophilic Disorders and Syndromes
- Eating Disorders and Behaviors
- Parasitic infections in humans and animals
- Nuclear physics research studies
- Food Allergy and Anaphylaxis Research
- Child Nutrition and Water Access
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Boston Children's Hospital
2024
SleepMed
2024
Centers for Disease Control and Prevention
2023
New York University
2019
University of Wisconsin–Madison
2019
Stanford Medicine
2019
Louisiana State University Health Sciences Center New Orleans
2018
Moscow Research and Clinical Center for Neuropsychiatry
2018
1. Kevin Gipson, MD, MS* 2. Mengdi Lu, MD* 3. T. Bernard Kinane, MD* 1. *Division of Pediatric Pulmonology and Sleep Medicine, Department Pediatrics, Massachusetts General Hospital for Children Harvard Medical School, Boston, MA * Abbreviations: AAP: : American Academy Pediatrics AHI: apnea-hypopnea index AT: adenotonsillectomy Bi-level: bilevel positive airway pressure CPAP: continuous CSA: central sleep apnea FDA: Food Drug Administration OSA: obstructive PAP: PSG:...
The increasing prevalence of HIV/AIDS in Africa over the past twenty-five years continues to erode continent's health care and overall welfare. There have been various responses pandemic, led by Uganda, which has had greatest success combating disease. Part Uganda's attributed a formalized information, education, communication (IEC) strategy, lowering estimated infection rates from 18.5% 1995 4.1% 2003. We formulate model investigate effects information education campaigns on HIV epidemic...
Abstract Importance Congenital chylothorax is a rare condition with pulmonary and multiorgan system effects, for which there are no standardized treatment recommendations. Collective review of known cases offers some conclusions suggestions treatment. Objective The aim this study was to present case series 5 patients who were treated in the neonatal intensive care unit chylothorax. Methods We describe infants diagnosed prenatally hydrops fetalis postnatally had clinically significant...
Summary Sleep‐disordered breathing is an important health issue for children. The objective of this study was to develop a machine learning classifier model the identification sleep apnea events taken exclusively from nasal air pressure measurements acquired during overnight polysomnography paediatric patients. A secondary differentiate site obstruction hypopnea event data using model. Computer vision classifiers were developed via transfer either normal while asleep, obstructive hypopnea,...
An 8-year-old male from south Louisiana was diagnosed with Loeffler syndrome of suspected Ascaris origin. Further investigation the farm recovered larvated, infective eggs soil in drains surrounding pens on family's small hog farm. Molecular analysis eggs, conjunction Ascaris-specific IgE, inadequate management and sanitation, behavioral risk factors indicate patient had an suum soil-transmitted infection.
Obstructive sleep apnea (OSA) is common in children with Down syndrome (DS). Adenoidectomy and/or tonsillectomy are the usual first interventions employed to treat OSA DS but sometimes do not achieve adequate resolution of clinical signs. Positive airway pressure treatment often used next, this poorly tolerated by population. Persistent can adversely affect a child’s health and cognitive development. Hypoglossal nerve stimulation (HGNS), previously shown be safe effective adults OSA, has...
Löffler syndrome, a fulminant eosinophilic pneumonitis associated with the larval migratory phase of human parasites, is rarely reported in United States. A previously healthy 8-year-old male was hospitalized tachypnea, cough, hypoxemia, and fever one week's duration. History revealed exposure to pigs on his family's farm southernmost Louisiana, where patient responsible for cleaning farm's pigpens. His fingernails were soiled extremely short, edge nail bed exposed secondary onychophagia....
Objective Tracheomalacia is characterized by weakness of the tracheal wall resulting in dynamic airway collapse during respiration; severe cases often require surgical intervention. Off‐label external splinting with degradable implants has been reported humans; however, there remains a need to develop splints tunable mechanical properties and degradation profiles for pediatric population. The objective this pilot study assess safety efficacy silk fibroin‐based clinically relevant preclinical...
Introduction Hypoglossal nerve stimulation (HGNS) is an effective therapy for carefully selected pediatric patients with Down syndrome (DS) and obstructive sleep apnea (OSA), but optimization of device settings has been focused on settings. The potential benefits sensing lead setting have not investigated. We describe a series three cases HGNS in children DS where both the settings, as well utilization drug‐induced endoscopy (DISE), when indicated, was more than alone. Methods Using our...
Objective(s) Hypoglossal nerve stimulation (HGNS) is safe and effective for patients with Down syndrome (DS) severe persistent obstructive sleep apnea (OSA). Long‐term outcomes this patient population have not been evaluated. Methods A prospective single‐group multicenter cohort study 1‐year follow‐up was conducted between 2015 2021 among 42 adolescent DS OSA. Here, we evaluate long‐term in cohort. Patients were evaluated polysomnogram (PSG) at three timepoints: pre‐implantation (timepoint...
Abstract Background Numerous lung associated diseased states such as acute pneumonia and cystic fibrosis (CF) are with increased concentrations of IL8 infiltration neutrophils (PMNs) in the airspace. production by epithelial cells (ECs) is stimulated Pseudomonas aeruginosa infection, an opportunistic pathogen involved pneumonia, infection CF patients. The exact role plays migration circulating PMNs into infected airspace still uncertain. Objective Assess mediating PMN response to P....
With the advances of culture-independent techniques, we now know that microbes, which were present on this planet way before were, have adapted to live in extreme conditions previously thought be inhospitable.