A5055133267- Hippo pathway signaling and YAP/TAZ
- Invertebrate Immune Response Mechanisms
- Evolution and Genetic Dynamics
- Microtubule and mitosis dynamics
- Neurobiology and Insect Physiology Research
- Genetics, Aging, and Longevity in Model Organisms
- Cellular transport and secretion
- Cancer-related Molecular Pathways
- Plant Surface Properties and Treatments
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Cellular Mechanics and Interactions
University of California, Berkeley
2022
University of Copenhagen
2017-2020
Animals have evolved mechanisms, such as cell competition, to remove dangerous or nonfunctional cells from a tissue. Tumor necrosis factor signaling can eliminate clonal malignancies Drosophila imaginal epithelia, but why this pathway is activated in tumor not normal tissue unknown. We show that the ligand drives elimination present basolateral circulation remains latent because it spatially segregated its apically localized receptor. Polarity defects associated with malignant transformation...
Cytokinesis failure may result in the formation of polyploid cells, and subsequent mitosis can lead to aneuploidy tumor formation. Tumor suppressor mechanisms limiting oncogenic potential these cells have been described. However, universal applicability tumor-suppressive barriers remains controversial. Here, we use Drosophila epithelial investigate consequences cytokinesis vivo. We report that cleavage defects trigger activation JNK pathway, leading downregulation inhibitor apoptosis DIAP1...
One of the fundamental issues in biology is understanding how organ size controlled. Tissue growth has to be carefully regulated generate well-functioning organs, and defects control can result tumor formation. The Hippo signaling pathway a universal regulator been implicated cancer. In Drosophila , acts through miRNA bantam regulate cell proliferation apoptosis. Even though targets regulating apoptosis have determined, target genes controlling not identified thus far. this study, we...
ABSTRACT Animal organs maintain tissue integrity and ensure removal of aberrant cells through several types surveillance mechanisms. One prominent example is the elimination polarity-deficient mutant within developing Drosophila imaginal discs. This has been proposed to require heterotypic cell competition dependent on receptor tyrosine phosphatase PTP10D cells. We report here experiments test this requirement in various contexts find that not obligately required for scribble (scrib) similar...