A5069283068- Antibiotic Use and Resistance
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Drug-Induced Adverse Reactions
- Antibiotic Resistance in Bacteria
- Neutropenia and Cancer Infections
- Pneumonia and Respiratory Infections
- Innovations in Medical Education
- HIV/AIDS Research and Interventions
- Nosocomial Infections in ICU
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Healthcare professionals’ stress and burnout
- Enterobacteriaceae and Cronobacter Research
- Clostridium difficile and Clostridium perfringens research
- Blood disorders and treatments
- Microscopic Colitis
- Antifungal resistance and susceptibility
- Adolescent Sexual and Reproductive Health
- HIV/AIDS Impact and Responses
- Adolescent and Pediatric Healthcare
- Healthcare Systems and Technology
- Chemotherapy-related skin toxicity
Brighton Hospital
2025
University of Rochester Medical Center
2018-2022
Strong Memorial Hospital
2019-2022
Carolinas Healthcare System
2016-2020
Atrium Medical Cente
2018
Merck (Germany)
2016
Background: Literature suggests that antibiotic prescribing in COVID-19 patients is high. Currently, there are insufficient data on what drives practices throughout the pandemic. Objective: This study sought to determine use rates and identify risk factors for hospitalized patients. It was first assess receiving more than 1 course of antibiotics. Methods: a retrospective, multi-center, observational study. Patients admitted from March 1, 2020, May 31, treated were included. The primary...
Abstract Background Young adults (YA) are particularly vulnerable to acquiring HIV due low self-perceived risk, rates of testing, and lack knowledge/awareness about pre-exposure prophylaxis (PrEP). Methods Between 3/23 – 8/23, six education sessions for YAs were conducted in the Southeastern U.S. by local healthcare professionals (HCPs) along with community-based organizations (CBOs) non-clinical settings (e.g. college campuses, breweries). Pre- post-surveys administered, follow-up surveys 3...
Abstract Background People with HIV (PWH) who are engaged in decision-making their provider more likely to report treatment satisfaction. Yet, tailored SDM tools for diverse populations of PWH lacking. Methods Four steering committees and expert providers convened develop groups living HIV, including gay bisexual men, cisgender women, aging adults, transgender individuals. From 9/23 – 12/23, the were implemented 4 clinics which entailed a short video introducing concept survey on tablet...
Abstract Background There is a paucity of data on durations antibiotic therapy utilized in clinical practice for patients with Gram-negative bloodstream infections (GN-BSI). The objectives this study were to describe treatment GN-BSI and evaluate variability across U.S. hospitals. Histogram Methods This was retrospective cohort hospitalized at 24 hospitals (16 academic, 4 community, Veterans Affairs) between January 1, 2019 December 31, 2019. Episodes from urinary, intra-abdominal,...
Abstract Background Substance use disorder (SUD) clinics are uniquely positioned to link patients with SUD HIV services. This project aimed bridge gaps in care within clinics. Methods From 6/2023-10/2023, healthcare professionals (HCPs) led 5 education sessions on testing, prevention, and management at West Virginia Delaware. Surveys were administered pre- post-sessions again 4-6 weeks later. Results informed a workshop for HCPs policy makers an online toolkit nationwide. completed by 67...
Abstract Background Older adults are at high risk for poor outcomes from infectious diseases, yet rates of recommended vaccinations remain low among this age group. This quality improvement initiative aimed to increase vaccination engagement older through patient-provider collaborative learning sessions (CLS) and use a customized shared decision-making (SDM) tool. Methods From 8/23 – 1/24, the CLS SDM tools were implemented in 6 primary care/geriatric clinics with surveys administered before...
Background The optimal duration of empiric antimicrobial therapy in febrile neutropenia unknown origin is unclear. This study evaluated outcomes autologous and allogeneic hematopoietic cell transplantation recipients with who received early de-escalation broad-spectrum antimicrobials prior to recovery versus those continued until recovery. Methods A single-center, retrospective assessed origin. Patients were categorized into either cohort 1, representing recovery, or 2, continuation Results...
Abstract Data on treatment durations for Gram-negative bloodstream infections (GN-BSI) in clinical practice are limited. In this study of 4,240 GN-BSI episodes during 2019 from 24 U.S. hospitals, the median duration therapy was 12 days (IQR 9-15); 59% were treated >10 days. There marked variability across hospitals.
Most patients who report a penicillin allergy can tolerate cefazolin, the preferred prophylaxis in total joint arthroplasty (TJA). Regardless, with reported are less likely to receive first-line perioperative antibiotics as result of inaccurate documentation and misconceptions regarding cross-reactivity between cephalosporins. The over-reporting allergies safety cephalosporins have been well established throughout evidence [13].The study sought answer two questions: (1) Do antibiotic...
Objectives: There is debate on whether the use of third-generation cephalosporins (3GC) increases risk clinical failure in bloodstream infections (BSIs) caused by chromosomally-mediated AmpC-producing Enterobacterales (CAE). This study evaluates impact definitive 3GC therapy versus other antibiotics outcomes BSIs due to Enterobacter, Serratia, or Citrobacter species. Methods: multicenter, retrospective cohort evaluated adult hospitalized patients with secondary species from 1 January 2006...
Abstract Purpose Persons who inject drugs (PWID) are at risk for severe gram-positive infections and may require prolonged hospitalization intravenous (IV) antibiotic therapy. Dalbavancin (DBV) is a long-acting lipoglycopeptide that reduce costs provide effective treatment in this population. Methods This was retrospective review of PWID with infections. Patients admitted from January 1, 2017, to November 2019 (standard-of-care [SOC] group) 15, 2019, March 31, 2022 (DBV were included. The...
Abstract Background Literature suggests that antibiotic prescribing in COVID-19 patients is high, despite low rates of confirmed bacterial infection. There are little data on what drives habits. Objective This study sought to determine and risk factors for hospitalized patients. It was the first assess receiving more than one course antibiotics. Methods a retrospective, multi-center, observational study. Patients admitted from March 1, 2020 May 31, treated PCR-confirmed were included. The...
Burnout in healthcare can have serious consequences, as it decreases patient care quality. Recent studies found pharmacy employees high rates of burnout, but formalized well-being programs are not reported the literature.We developed a departmental program and focused residency October July 2020, respectively. The committees sent anonymous surveys to all identify opportunities improve well-being. feasibility impact ideas were assessed by committee members presented leadership who endorsed...
Abstract Broad-spectrum antibiotics with once-daily dosing are often chosen for outpatient parenteral antibiotic therapy (OPAT) due to convenience even when narrower-spectrum appropriate. At our institution, up 50% of select broad-spectrum OPAT regimens had potential be narrowed, highlighting the need re-evaluate de-escalation prior discharge.
Acute bacterial skin and structure infections (ABSSSI) are a leading cause of hospitalization, but often treated inappropriately in the inpatient setting. A multifaceted stewardship intervention was implemented to encourage prescribing guideline-concordant therapy (GCT).To examine impact this initiative on antimicrobial practices patient outcomes.This single-center, retrospective study adult inpatients admitted with primary or secondary diagnosis ABSSSI, classified by type severity based...
Background: Carbapenem-resistant Enterobacterales (CRE) are difficult to treat and can cause significant morbidity mortality, however most data reflect carbapenemase-producing infections. Objective: Our objective was evaluate clinical outcomes of non-carbapenemase-producing CRE (nCP-CRE) compared with carbapenem-susceptible (CSE) Methods: This a retrospective, multicenter, observational study (January 1, 2018 December 31, 2020). The primary outcome success at 30 days secondary outcomes,...
Infections caused by carbapenem resistant Enterobacteriaceae (CRE) are associated with high mortality. Optimal treatment for CRE bacteremia remains unclear, including the role of combination therapy, carbapenem-containing regimens, or newer antimicrobials, such as ceftazidime-avibactam (CAZ-AVI). The objective this study was to evaluate risk factors mortality in patients bacteremia, a focus on antimicrobial therapy. This multicenter, retrospective cohort inpatients within Carolinas...
Acute bacterial skin and structure infections (ABSSSI) are a leading cause of hospitalization; however, ABSSSI often treated inappropriately in the inpatient setting. A multifaceted stewardship intervention was implemented at large health care system to encourage guideline-concordant (GC) antibiotic prescribing. Components included development clinical pathway, computerized order set, provider education. The objective this study examine impact initiative on antimicrobial prescribing...
The authors declare no conflicts of interest.
Inappropriate antimicrobial use is one of the key contributors in increase resistance facing clinicians today. Incomplete documentation or assessment medication allergies can play a significant role inappropriate utilization antimicrobials. It reported that 10% to 30% patients have an allergy 1 more antimicrobials.1 The most common antimicrobials penicillin (PCN), with rate 15% hospitalized labeled as PCN allergic.2 In study 198 primary care providers within academic medical center treating...