Abstract There is a critical unmet need for scalable, accessible and objective diagnostic tests stratification in dementia. Biofluid Raman spectroscopy (RS) due to its simplicity, holistic label-free nature, powerful approach that has the potential offer differential diagnosis across dementia types including Alzheimer’s disease (AD). RS laser-based optical method can rapidly provide chemically rich information (‘spectral biomarkers’) from biofluids but utility AD not been established...

The Alzheimer's Disease COMposite Score (ADCOMS) is more sensitive in clinical trials than conventional measures when assessing pre-dementia. This study compares ADCOMS trajectories using clustered progression characteristics to better understand different patterns of decline.

Objectives With disease-modifying therapies in development for neurological disorders, quantitative brain imaging techniques become increasingly relevant objective early diagnosis and assessment of response to treatment. The aim this study was evaluate the use Brain SPECT PET scans UK explore drivers barriers using analysis through an online survey. Methods A web-based survey with 27 questions used capture a snapshot UK. included multiple-choice assessing availability quantification DaTscan,...

The aim of this study was to investigate the diagnostic value occipital lobe and posterior cingulate perfusion in predicting dopamine transporter imaging outcome using a quantitative measure analysis.In total, 99 patients with cognitive complaints who had undergone both technetium-99m-hexamethylpropyleneamine oxime single-photon emission computed tomography (Tc-HMPAO SPECT) I ioflupane (I-FP-CIT also called DaTSCAN) dementia center were analyzed. Measures calculated from HMPAO SPECT images...

Background: Neuroinflammation is an integral part of Alzheimer’s disease (AD) pathology. Inflammatory mediators can exacerbate the production amyloid-β (Aβ), propagation tau pathology and neuronal loss. Objective: To evaluate relationship between inflammation markers established AD in a mixed memory clinic cohort. Methods: 105 cerebrospinal fluid (CSF) samples from clinical cohort under investigation for cognitive complaints were analyzed. Levels Aβ42, total tau, phosphorylated measured as...

Cerebrospinal fluid (CSF) protein biomarkers show good concordance with underlying Alzheimer's disease pathology, however the technique is invasive and not widely available. Single photon emission computed tomography (SPECT) perfusion brain imaging commonly used for dementia diagnosis, there has been little validation of specific patterns on SPECT prediction pathology in clinical settings where diagnosis uncertain. We hypothesise that can predict AD CSF biomarker pathology. A series 58...

Abstract Background Neuroinflammation is an integral part of Alzheimer’s Disease (AD) pathology, whereby inflammatory processes contribute to the production amyloid‐β, propagation tau and neuronal loss. We recently investigated data‐driven methods for determining distinct progression trajectory groups on ADCOMS scale. This study evaluates whether biomarkers inflammation in cerebrospinal fluid (CSF) can predict rate membership those groups. Method ADNI’s Biomarkers Consortium dataset provided...

Abstract Background Prognosis for Alzheimer’s disease is difficult, with rates of progression varying widely. Despite the extensive use clinical dementia severity assessment scales to determine diagnosis and monitor progression, there no consensus on which imaging factors may accurately predict future decline trajectories these measures. Determination baseline patterns that are related slower, or faster, could be used identify those at highest risk worse outcomes inform care planning. Method...

Posterior cortical hypoperfusion in Lewy Body Disease (LBD) has previously been demonstrated using (99m)Tc-HMPAO-SPECT imaging, but it is unclear whether occipital perfusion can be used to differentiate LBD from other neurodegenerative conditions. 123 I-FP-CIT SPECT (DaTscan) imaging shows high concordance with striatal loss of dopaminergic function and Parkinsonian To improve the reliability HMPAO-SPECT reporting, important understand extent which may diagnostically specific patients...

The Addenbrooke's Cognitive Examination is a useful cognitive screening tool for dementia, with recommended cut-off scores high sensitivity (83/100) and specificity (88/100). usefulness of dependent on their ability to determine whether further diagnostic testing required it has been suggested that lower are more appropriate. Currently, there no validation the ACE-R against an independent marker underlying neuropathology. We chose investigate validity identify in relation statistically...

Single photon emission computed tomography (SPECT) perfusion brain imaging is commonly used for dementia diagnosis, however there has been little validation of patterns that can predict AD likelihood in mixed clinical samples where diagnostic ambiguity. Cerebrospinal fluid (CSF) protein biomarkers are well established as the “gold standard” antemortem method to detect Alzheimer’s disease (AD) pathology, invasive and not widely available. The Paris-North, Lille Montpellier (PLM) CSF scale...

Perfusion brain imaging through single photon emission computed tomography (SPECT) is a less favoured modality for dementia diagnosis, however it widely available and cheaper than its alternatives. Clinical reporting of perfusion SPECT images difficult there are few validated ranking scales to aid image interpretation diagnosis. In addition, statistical parametric mapping (SPM) comparisons the individual against control database seldom used clinically, despite giving improved detection...

Abstract Background Neuroinflammation and activation of the immune system is an integral part Alzheimer’s Dementia (AD) pathology. Inflammatory mediators exacerbate production amyloid‐β, propagation tau pathology neuronal loss. This study evaluates whether CSF markers inflammation can help evaluate changes in amyloid a heterogenous clinical population. Methods samples from 105 patients referred to Wessex Neurology Clinic due cognitive complaints were analysed. Measurements AD biomarkers used...

Single photon emission tomography (SPECT) can detect early changes in brain perfusion to support the diagnosis of dementia. Inflammation is a driver for dementia progression and measures inflammation may further diagnosis. In this study, we assessed whether combining imaging with markers improves prediction likelihood Alzheimer's disease (AD). We analyzed 91 participants datasets (Institutional Ethics Approval 20/NW/0222). AD biomarkers were measured cerebrospinal fluid. Statistical...

Abstract Background Blood brain barrier dysfunction amplifies neuroinflammation, which may drive Alzheimer’s Dementia (AD) pathology. Regional cerebral blood flow (RCBF), measured by HMPAO SPECT, is an established biomarker for AD diagnosis. Matrix Metalloproteinase‐10 (MMP‐10), enzyme involved in function through regulating the breakdown of extracellular matrix, was recently proposed as a progression to AD. In this study, we examine relationship between RCBF and levels MMP‐10 cerebrospinal...

Dementia caregivers frequently report high levels of stress, with increased caregiver burden associated worse outcomes for both patients and caregivers. Although many studies show how clinical phenotypes relate to burden, there is little information as pathological deficits seen on imaging may regardless diagnosis. This study aimed investigate the relationship between regional functional perfusion imaging. 77 consecutive individuals recruited BraIID cognitive impairment undergoing...

Dementia caregivers frequently report high stress, with increased burden associated worse outcomes for both patients and caregivers. Although many studies relate clinical phenotypes to burden, the relationship between imaging pathology irrespective of diagnosis, is unknown. This study investigated caregiver patient regional cerebral blood flow in dementia.Seventy-sev en cognitive impairment undergoing brain perfusion single-photon emission computed tomography normal care their were...

Perfusion brain single photon emission computed tomography (SPECT) imaging is commonly used to aid dementia diagnosis; however the relationship between specific patterns and longitudinal functional decline in unselected patient cohorts has not been fully explored. This study aimed investigate whether perfusion SPECT could provide useful information prognosis. 117 individuals with cognitive complaints who underwent due diagnostic doubt were consented Brain Imaging Dementia (BraIID) study, a...