A5032570685- Ocular Oncology and Treatments
- Wound Healing and Treatments
- Phytochemicals and Antioxidant Activities
- Bee Products Chemical Analysis
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Child Nutrition and Water Access
- Histiocytic Disorders and Treatments
- Corneal Surgery and Treatments
- Homelessness and Social Issues
- Berberine and alkaloids research
- Essential Oils and Antimicrobial Activity
- Hepatitis B Virus Studies
- Natural Antidiabetic Agents Studies
- Pomegranate: compositions and health benefits
- Diabetic Foot Ulcer Assessment and Management
- CAR-T cell therapy research
- Cancer-related Molecular Pathways
- HIV-related health complications and treatments
- CNS Lymphoma Diagnosis and Treatment
- Fecal contamination and water quality
- Wastewater Treatment and Reuse
- Ocular Infections and Treatments
- Genital Health and Disease
- Virus-based gene therapy research
University of Zambia
2020-2023
University Teaching Hospital
2022
Tropical Gastroenterology & Nutrition group
2021
UCSI University
2014-2019
1. Diabetic chronic wounds, mainly foot ulcers, constitute one of the most common complications poorly managed diabetes mellitus. The typical reasons are insufficient glycemic management, latent neuropathy, peripheral vascular disease, and neglected care. In addition, it is a cause osteomyelitis amputation lower extremities. Patients admitted in larger numbers attributable to wounds compared any other diabetic disease. United States, currently non-traumatic amputations. Approximately five...
Abstract Environmental enteropathy is a major contributor to growth faltering in millions of children Africa and South Asia. We carried out longitudinal, observational interventional study Lusaka, Zambia, 297 with stunting (aged 2–17 months at recruitment) 46 control who had good 1–5 recruitment). Control contributed data only baseline. Children were provided nutritional supplementation daily cornmeal-soy blend, an egg micronutrient sprinkle, followed up 24 age. whose did not improve over...
Yes-associated protein-1 (YAP-1) is a Hippo system transcription factor, which serves as an oncogene in squamous cell carcinoma, and several solid tumors when the pathway dysregulated. Yet, activity of YAP-1 ocular surface neoplasia (OSSN) has not been determined. Here, we investigate relationship between overexpression OSSN. Using cross-sectional study design, recruited 227 OSSN patients from University Teaching Hospitals Lusaka, Zambia. Immunohistochemistry was used to assess protein tumor...
<b><i>Aim:</i></b> This study aimed to characterize the clinical and pathologic presentation of ocular surface tumors (OSTs) more precisely differentiate grades squamous neoplasia (OSSN) benign lesions among Zambians. <b><i>Methods:</i></b> Two-hundred sixty-five Zambian patients presenting with growths, suspicious for OSSN, were recruited between November 2017 2019 a cross-sectional investigate their lesions. Sociodemographic data collected,...
The etiopathogenesis of ocular surface squamous neoplasia (OSSN) is not fully understood. We assessed the frequency oncogenic viruses in OSSN by immunohistochemistry (IHC) and polymerase chain reaction (PCR) for human papillomavirus (HPV), Epstein-Barr virus (EBV), Merkel cell polyomavirus (MCPyV), Kaposi sarcoma virus, adenovirus. Cases from Zambia were prospectively enrolled using a cross-sectional study design between November 2017 March 2020.Demographic clinical data [age, sex, HIV...
Background: Skin regeneration is critical in diabetic wound healing. Anti-inflammatory activity of 2-Pentadecanone (2-P), identified from Marantodes pumilum was reported our previous studies. Objective: This study aimed at evaluating 2-P healing and anti-bacterial activities. Materials Methods: Fifteen streptozotocin-induced type 2 Sprague Dawley rats were divided into negative (N), positive (P), treatment (2-P) groups. aqueous cream applied daily to 5 mm excision wounds up day 15. Wound...
Diabetic mellitus is a metabolic disease primarily defined by the level of hyperglycemia that gives rise to complications such as retinopathy, nephropathy, and neuropathy. Reactive oxygen species (ROS) generation impaired antioxidant defense systems have been implicated in development diabetes mellitus. Palmatine protoberberine alkaloid has shown potential for treatment hypertension, inflammation, liver-related diseases. Our study aimed at evaluating blood plasma glucose lowering, vivo...
(1) The complexity of diabetes and diabetic wound healing remains a therapeutic challenge because proper systematic care management are essential to prevent chronic microbial infection mechanical damage the skin. Marantodes pumilum, locally known as 'Kacip Fatimah', is an herb that has been previously reported possess anti-inflammatory, analgesic, antinociceptive antipyretic properties. current study aims assess antioxidant fibroblast cell migration activities fractions eluded from...
A cross-sectional study was conducted to determine the seroprevalence of Human Immunodeficiency Virus (HIV), Hepatitis B (HBV), and C (HCV) viruses among forensic autopsy cases at University Teaching Hospital, Lusaka Zambia. The enrolled three hundred adult decedents with a median age 34 (interquartile range: 28 - –42) years, range (18–67). Males predominated (87.1 %). HIV, HBV, HCV, HIV HBV co-infection 32.7 %, 7.9 1.3 % 2.6 respectively. infection highest in suicides (37.8 %) accidents...
Background: Ocular surface squamous neoplasia (OSSN) includes pre-invasive and invasive lesions of the ocular surface. Current diagnosis relies on surgical excision histology, with potential complications. This study assessed reliability methylene blue staining as a non-invasive diagnostic tool for OSSN at University Teaching Hospitals – Eye Hospital in Lusaka, Zambia.Aim: aimed to evaluate accuracy diagnosing OSSN.Setting: The took place Hospitals-Eye Hospital, Zambia, between February 2022...
Background: Globally, women living with HIV have a higher risk of vulvar neoplasia than HIV-negative women. Vulvar among has not previously been characterised in Zambia. Objective: This study determined the clinical and pathologic features at University Teaching Hospital, Lusaka, Methods: We conducted cross-sectional lesions 53 who presented between July 2017 February 2018. The assessed histological characteristics prevalence high-risk human papillomavirus (HRHPV). Results: Twenty-one...
This study is aimed at investigating the effect of partially purified leaf extract Labisia Pumila (LP) on Indomethacin (IND) induced ulcer and selected antioxidant enzymes: ‐ catalase (CAT), glutathione (GSH), superoxide dismutase (SOD) lipid peroxidation(LPO). Column chromatography was used to purify DCM crude into 4 fractions (A, B, C D). 10mg/kg administered for 5 days induce ulcer. The oral administration LP D) a concentration 100mg/kg were found inhibit IND gastric lesions by 67.5%,...
Kaposi sarcoma (KS), a multifocal vascular neoplasm frequently observed in HIV-positive individuals, primarily affects the skin, mucous membranes, visceral organs, and lymph nodes. KS is associated with sarcoma-associated herpesvirus (KSHV) infection. In this case report, we present rare occurrence of co-infection co-localization KSHV Epstein-Barr virus (EBV) arising from conjunctiva, which, to our knowledge, has not been reported previously. Immunohistochemistry (IHC), DNA polymerase chain...
Background: The second leading cause of cancer-related deaths worldwide is colorectal cancer. With an incidence rate 4.8 per 100,000, this Zambia’s sixth most prevalent cancer;
 
 Methods: This laboratory-based, cross-sectional study examined the frequency Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation and its association with prognostic factors in carcinoma cases from University Teaching Hospital-Adult Hospital (UTHs), Lusaka, Zambia;
 Results: Thirty (30)...
Background: The second leading cause of cancer-related deaths worldwide is colorectal cancer. With an incidence rate 4.8 per 100,000, this Zambia’s sixth most prevalent cancer;
 Methods: This laboratory-based, cross-sectional study examined the frequency Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation and its association with prognostic factors in carcinoma cases from University Teaching Hospital-Adult Hospital (UTHs), Lusaka, Zambia;
 Results: Thirty (30) formalin-fixed...