A5075904503- Essential Oils and Antimicrobial Activity
- Plant biochemistry and biosynthesis
- Natural product bioactivities and synthesis
- Skin Protection and Aging
- Plant chemical constituents analysis
- Analytical Methods in Pharmaceuticals
- Phytochemistry and Biological Activities
- Forensic Toxicology and Drug Analysis
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Alzheimer's disease research and treatments
- Genomics, phytochemicals, and oxidative stress
- Exercise and Physiological Responses
- Melanoma and MAPK Pathways
- Cholinesterase and Neurodegenerative Diseases
- Biochemical and biochemical processes
- Glutathione Transferases and Polymorphisms
- Ginkgo biloba and Cashew Applications
- Inflammatory mediators and NSAID effects
- Neurotransmitter Receptor Influence on Behavior
- Pesticide Residue Analysis and Safety
- Dermatology and Skin Diseases
- Curcumin's Biomedical Applications
- Bone Metabolism and Diseases
- Fungal Biology and Applications
University of Coimbra
2018-2024
Centro de Neurociências e Biologia Celular
2023
Universidade Federal de São Paulo
2023
Universidade do Porto
2016-2020
Rede de Química e Tecnologia
2016-2020
Eucalyptus globulus is planted extensively for pulp, paper and wood production. Although bioactive compounds obtained from its biomass are used as cosmetics ingredients, the skin effects were not yet fully explored. In order to fill this gap, work aimed study protective effect against damage provided by essential oil (EO) hydrodistillation of leaves, an extract residual water (HRW). The major compound identified in EO was 1,8-Cineole, phenolic acids HRW included gallic acid main constituent....
Bacterial nanocellulose (BNC) membranes, with remarkable physical and mechanical properties, emerged as a versatile biopolymeric carrier of bioactive compounds for skin care applications. In this study, BNC membranes were loaded glycerol (as plasticizer humectant agent) different doses (1-3 μg cm-2) an aqueous extract obtained from the hydro-distillation Eucalyptus globulus Labill. leaves (HDE), application sheet facial masks. All are resistant highly malleable at dry wet states, similar or...
Acacia dealbata biomass, either from forest exploitation or the management of invasive species, can be a strategic topic, namely as source high-value compounds. In this sense, present study aimed at detailed characterization lipophilic components different morphological parts A. and evaluation their cytotoxicity in cells representative mammals' tissues. The chemical composition extracts bark, wood leaves was evaluated using gas chromatography-mass spectrometry (GC-MS). Terpenic compounds...
E. globulus leaves have been mainly exploited for essential oil recovery or energy generation in industrial pulp mills, neglecting the abundance of valuable families extractives, namely, triterpenic acids, that might open new ways integrated valorization this biomass. Therefore, study highlights lipophilic characterization before and after hydrodistillation, aiming at both oils acids. The composition hydrodistillation is reported first time. Extracts were obtained by dichloromethane Soxhlet...
With the increase in global life expectancy, maintaining health into old age becomes a challenge, and research has thus concentrated on various strategies which aimed to mitigate effects of skin aging. Aromatic plants stand out as promising sources anti-aging compounds due their secondary metabolites, particularly essential oils (EOs). The aim this study was ascribe Ferulago lutea EO several biological activities that could be useful context obtained using hydrodistillation characterized by...
Experimental evidence highlights nuclear factor (erythroid-derived 2)-like 2 (Nrf2) as a molecular target in Alzheimer’s disease (AD). The well-known effect of electrophilic cysteine-reactive skin allergens on Nrf2-activation led to the hypothesis that these compounds could have therapeutic role AD. This was further supported by neuroprotective activity allergen dimethyl fumarate (DMF), demonstrated vivo models neurodegenerative diseases. We evaluated 1,4-phenylenediamine (PPD) and methyl...
A disease-modifying therapy for Alzheimer's disease (AD) is still an unmet clinical need. The formation of amyloid-β (Aβ) requires the initial cleavage protein precursor (AβPP) by BACE1 (beta-site AβPP cleaving enzyme 1), which a prime therapeutic target AD.We aimed to design and develop selective inhibitor suitable AD treatment.The new inhibitors consist on chimeric peptide including sequence related human Swedish mutant form (AβPPswe) conjugated with TAT carrier that facilitates cell...
Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability inhibit amyloid-β (Aβ) peptide aggregates and destabilise pre-formed ones. Derivative 27 was synthesized improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant anti-amyloidogenic activities were evaluated chemico, vitro using AD neuroinflammation cell models, vivo double-transgenic APP/PS1 mice. In vitro, this curcumin derivative significantly reduced nitric oxide...
As global life expectancy continues to rise, we are challenged with maintaining health into old age, and research has thus concentrated on various strategies aimed at mitigating the effects of skin aging. Aromatic plants stand out as potential sources anti-aging compounds due their secondary metabolites, particularly essential oils (EO). The aim this study was ascribe Ferulago lutea EO several biological activities that could be useful in context obtained using hydrodistillation...
Alzheimer´s disease is a neurodegenerative and the most common cause of dementia with no cure or treatment. Therefore, investigation to find disease-modifying therapeutic crucial. From pathophysiological point view, AD characterized by loss homeostatic functions that control redox energy metabolism, neuroinflammation, proteostasis. The transcription factor nuclear erythroid 2–related 2 (Nrf2) master controller these and, in past decades, recent reports have shown its overall activity...
An integrated process using Eucalyptus globulus essential oil as a bio-based solvent to extract triterpenic acids from hydrodistilled leaves is discussed.
A 74-year-old woman with a history of Charcot-Marie-Tooth type 1 neuropathy and malignant melanoma (TxN3bM0), diagnosed in 2023 previously treated pembrolizumab, presented to the emergency department acute-on-chronic anemia (2 g/dL hemoglobin drop), heart failure, abdominal pain, hypotension, melena.
In postmenopausal women, vitamin D deficiency has been associated with disability, low muscle mass and fractures. Irisin is an important myokine that may contribute to the maintenance of bone density. Vitamin growth function tissue through interactions between receptor PGC-1α activation p38/MAPK (mitogen-activated protein kinase) in muscle, a mechanism similar irisin action. The aim this pilot study was evaluate effects cholecalciferol supplementation on serum levels sedentary women...
Ethnopharmacological relevanceSkin aging results from senescent cells accumulation, matrix metalloproteinases (MMPs) overproduction, and collagen elastin degradation, which in turn trigger skin pigmentation, dryness, wrinkles formation. In addition, the so-called inflammaging plays a role both several pathologies of skin. One most common invasive plants agroforest industrial forest plantations is Acacia dealbata, studies have been performed on pharmacological properties species due to their...
1-Benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl) piperazine (TFMPP) are drugs of abuse often taken in combination. Considering the frequency co-administration BZP TFMPP clinical, analytical forensic contexts its toxicological impact, we aimed to implement a gas chromatography-mass spectrometry (GC-MS) technique for detection simultaneous quantification plasma, urine cell culture medium.