A5067850783- Child Abuse and Trauma
- Electrochemical sensors and biosensors
- Evaluation and Performance Assessment
- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- Homicide, Infanticide, and Child Abuse
- Meta-analysis and systematic reviews
- Health Policy Implementation Science
- Pancreatic function and diabetes
- Child Welfare and Adoption
- Educational Assessment and Improvement
- Diabetes Management and Research
- Homelessness and Social Issues
- Intimate Partner and Family Violence
- Delphi Technique in Research
- Healthcare innovation and challenges
- Microfluidic and Capillary Electrophoresis Applications
- Health Sciences Research and Education
- Nanoparticle-Based Drug Delivery
- Image Processing Techniques and Applications
- Community Health and Development
- Child Abuse and Related Trauma
- Advanced Fluorescence Microscopy Techniques
- Primary Care and Health Outcomes
- Computational Drug Discovery Methods
University College London
1998-2022
University of Bristol
2020
New York University Press
2020
University of Chicago
2020
University of Pennsylvania
2020
John F. Kennedy University
2020
University of California, San Diego
2006-2018
University of London
1998-2016
La Jolla Bioengineering Institute
1995-2016
Universidad de Londres
2013-2016
Knowledge use and production is complex so also are attempts to judge its quality. Research synthesis a set of formal processes determine what known from research in relation different questions this process requires judgements the quality relevance evidence considered. Such judgement can be according generic standards or specific review question. The interact with other such as inclusion criteria search strategies absolute weighted combined Weight Evidence framework. Judgements vary...
An ambitious goal of proteomics is to elucidate the structure, interactions and functions all proteins within cells organisms. The expectation that this will provide a fuller appreciation cellular processes networks at protein level, ultimately leading better understanding disease mechanisms suggesting new means for intervention. This paper addresses question: can protein-protein be predicted directly from primary structure associated data? Using diverse database known interactions, Support...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMembrane-covered, rotated disk electrodeDavid A. Gough and John K. LeypoldtCite this: Anal. Chem. 1979, 51, 3, 439–444Publication Date (Print):March 1, 1979Publication History Published online1 May 2002Published inissue 1 March 1979https://pubs.acs.org/doi/10.1021/ac50039a028https://doi.org/10.1021/ac50039a028research-articleACS PublicationsRequest reuse permissionsArticle Views619Altmetric-Citations174LEARN ABOUT THESE METRICSArticle Views are the...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTwo-dimensional enzyme electrode sensor for glucoseDavid A. Gough, Joseph Y. Lucisano, and Pius H. S. TseCite this: Anal. Chem. 1985, 57, 12, 2351–2357Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://doi.org/10.1021/ac00289a042Request reuse permissionsArticle Views975Altmetric-Citations185LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text...
An implanted tissue glucose sensor can provide stable readings of concentrations for more than a year.
Objective-The use of a fully implanted, first-generation prototype sensor/telemetry system is described for long-term monitoring subcutaneous tissue glucose in small cohort people with diabetes.Methods-Sensors are based on membrane containing immobilized oxidase and catalase coupled to oxygen electrodes telemetry system, integrated as an implant.The devices remained implanted up 180 days, signals transmitted every 2 minutes external receivers.Results-The data include signal recordings from...
An intravenous glucose sensor was implanted in six dogs for 1–15 wk. The is a flexible cylinder, ∼0.2 cm diam and 30 long, with tip containing immobilized oxidase catalase coupled to potentiostatic O2 sensor. similar reference were the superior vena cava near entrance of right atrium. response conveyed externally either by telemetry system nearby, surgically accessed leads, or chronically maintained percutaneous leads. Summing over implants, there total implantation period 333 days during...
Issues surrounding the role and provision of evidence to inform policy practice have become topical problematic. The context these controversies is discussed, with particular emphasis on systematic approaches synthesising research evidence. We contrast ‘positivist’ interpretative qualitative synthesis, suggest that many viewpoints unnecessarily unhelpfully polarised. methods for syntheses will vary as they depend question being asked. process transparent, allowing readers see how conclusions...
An important question about blood glucose control in diabetes is, Can present and future values be predicted from recent history? If this is possible, new continuous monitoring technologies under development may lead to qualitatively better therapeutic capabilities. Not only could alert a user when hypoglycemic episode or other excursion underway, but measurements also provide sufficient information predict near-future values. A predictive capability based on history would advantageous...
A major post-genomic scientific and technological pursuit is to describe the functions performed by proteins encoded genome. One strategy first identify protein-protein interactions in a proteome, then determine pathways overall structure relating these interactions, finally statistically infer functional roles of individual proteins. Although huge amounts genomic data are at hand, current experimental protein interaction assays must overcome technical problems scale-up for high-throughput...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTModel of a two-substrate enzyme electrode for glucoseJohn K. Leypoldt and David A. GoughCite this: Anal. Chem. 1984, 56, 14, 2896–2904Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://pubs.acs.org/doi/10.1021/ac00278a063https://doi.org/10.1021/ac00278a063research-articleACS PublicationsRequest reuse permissionsArticle Views489Altmetric-Citations93LEARN ABOUT THESE...
English The ‘evidence movement’ poses particular challenges to social science. This article describes and reflects on some of these challenges, using as a case study the development over period from 1993 Evidence for Policy Practice Information Coordinating (EPPI-Centre) at Institute Education, University London. EPPICentre resources supporting evidence-informed policy in fields education health promotion, so doing explores many that confront research reviewers sciences. These include...
Systematic reviews are still a controversial topic in some quarters, with the arguments for and against their use being well‐rehearsed. In an attempt to advance more nuanced approach thinking about systematic reviewing, this paper illustrates wide range of theoretical perspectives, methodologies purposes that underpin vast review approaches now available; light picture, re‐examines perennial reviews, arguing they often poorly targeted, based on misreading what aim do, or simply...
For research evidence to inform decision making, an appraisal needs be made of whether the claims are justified and they useful decisions being made. This chapter provides a high level framework core issues relevant appraising “fitness for purpose” claims. The includes (I) variation in nature research, it produces, values, perspectives, ethical that underlie it; (II) main components bases terms (i) how has been identified synthesized make claim, (ii) technical quality relevance included...