A5057428953- Colorectal Cancer Treatments and Studies
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Chronic Lymphocytic Leukemia Research
- Cancer therapeutics and mechanisms
- Child Nutrition and Water Access
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Pregnancy and Medication Impact
- Lung Cancer Research Studies
- Renal Diseases and Glomerulopathies
- Enzyme Structure and Function
- Cancer Mechanisms and Therapy
- Bipolar Disorder and Treatment
- Cell death mechanisms and regulation
- Physical Education and Training Studies
- Sports and Physical Education Research
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Museums and Cultural Heritage
- Genomic variations and chromosomal abnormalities
Motilal Nehru Medical College
2022-2024
Queen's University Belfast
2018-2024
Royal Marsden Hospital
2014-2016
Royal Marsden NHS Foundation Trust
2014-2015
Florida State University
2013
AbstractUnderstanding the connections between scientific inquiry and digital literacy in informal learning environments is essential to furthering students' critical thinking technology skills. The Habitat Tracker project combines a standards-based curriculum focused on nature of science with an integrated system online mobile computing technologies designed help students learn about participate formal classroom settings such as museums or wildlife centers. This research documents skills...
Patient suitability to anti-programmed death ligand 1 (PD-L1) immune checkpoint inhibition is key the treatment of NSCLC. We present, applied PD-L1 testing: a comprehensive cross-validation two immunohistochemistry (IHC) clones; our descriptive experience in diagnostic reflex testing; concordance IHC situ RNA (RNA-ISH); and application digital pathology.
Detection of the ALK rearrangement in a solid tumor gives these patients option crizotinib as an oral form anticancer treatment. The current test choice is fluorescence situ hybridization (FISH), but various cheaper and more convenient immunohistochemical (IHC) assays have been proposed alternatives.
Novel covalent inhibitors of KRASG12C have shown limited response rates in patients with KRASG12C-mutant (MT) colorectal cancer. Thus, novel inhibitor combination strategies that can achieve deep and durable responses are needed. Small-molecule AZ'1569 AZ'8037 were used. To identify candidate for AZ'1569, we performed RNA sequencing, siRNA, high-throughput drug screening. Top hits validated a panel KRASG12CMT cancer cells vivo. AZ'1569-resistant generated characterized. We found to was...
Abstract Acute promyelocytic leukaemia (APL) with a STAT5b::RARα gene fusion is an extremely rare subtype of APL characterised by resistance to conventional therapies and poor prognosis. This case highlights that whilst variant RARα translocations are rare, they do pose significant challenges both diagnostically in their clinical management. case, the first instance, demonstrates importance using combination molecular techniques including next generation sequencing (NGS) for diagnosis...
Infants are more vulnerable to malnutrition as compared with older children. Prevalence of severe wasting in Indian infants under 6 months age (U6M) is 14.8% (National Family Health Survey 4, 2015-2016). Weight for length z-score (WLZ) and mid-upper arm circumference (MUAC) 2 anthropometric parameters detecting acute (SAM) children aged 5 years. But U6M, currently no accepted MUAC criteria present SAM. Calculating WLZ practically difficult cumbersome measuring MUAC. We tried find out whether...
Whilst adequate for most existing pathological tests, formalin is generally considered a poor DNA preservative and use of alternative fixatives may prove advantageous molecular testing tumour material; an increasingly common approach to identify targetable driver mutations in lung cancer patients. We collected paired PAXgene® tissue-fixed formalin-fixed samples block-sized parenchyma, Temno-needle core biopsies fine needle aspirates (FNAs) from non-small cell resection specimens....
Limited data exists to show the correlation of (tumour protein 53) TP53 mutation detected by Next generation sequencing (NGS) and presence/absence deletions 17p13 FISH. The study which is largest series date includes 2332 CLL patients referred for analysis del(17p) FISH mutations NGS before treatment. Using a 10% variant allele frequency (VAF) threshold, cases were segregated into high burden (≥10%) low (<10%). aberrations (17p [del(17p)] and/or mutation) in 320/2332 (13.7%)....
There is an urgent need to identify molecular signatures in small cell lung cancer (SCLC) that may select patients who are likely respond molecularly targeted therapies. In this study, we investigate the feasibility of undertaking focused analyses on routine diagnostic biopsies with SCLC. A series histopathologically confirmed formalin-fixed, paraffin-embedded SCLC specimens were analysed for epidermal growth factor receptors (EGFR), KRAS, NRAS and BRAF mutations, ALK gene rearrangements MET...
IntroductionPhase I of the Cancer Research UK Stratified Medicine Programme (SMP1) was designed to roll out molecular pathology testing nationwide at point cancer diagnosis, as well facilitate an infrastructure where surplus tissue could be used for research. It offered a non-trial setting examine common genetics in real-world context.MethodsA total 26 sites England, Wales and Scotland, recruited samples from 7814 patients genetic examination between 2011 2013. Tumour types involved were...
Zinc deficiency, common in children of developing countries, leads to susceptibility infections. Relapses nephrotic syndrome are precipitated mostly by Most morbidity and mortality patients is during range proteinuria. Management factors which reduce duration relapse, can decrease pediatric patients. We aimed study serum zinc levels, syndrome, at onset/relapse remission tried find out correlation between levels time achieve remission. Observational was conducted tertiary centre North India...
A sedentary lifestyle poses a serious threat to individual health. It can lead an increase or progression in the risk of hypertension, obesity and muscle weakness. An physical activity improves overall health individual. Aerobic dance moves has become gradually more popular fitness activity. In this set are executed together form choreography class
<p>Supplementary figures</p>
<p>Supplementary materials and methods</p>
<p>antibodies</p>
<p>concentrations of drugs</p>
<p>Supplementary figures</p>
<div>Abstract<p>Novel covalent inhibitors of KRAS<sup>G12C</sup> have shown limited response rates in patients with <i>KRAS</i><sup>G12C</sup>-mutant (MT) colorectal cancer. Thus, novel inhibitor combination strategies that can achieve deep and durable responses are needed. Small-molecule <i>KRAS</i><sup>G12C</sup> AZ’1569 AZ’8037 were used. To identify candidate for AZ’1569, we performed RNA sequencing, siRNA,...
<div>Abstract<p>Novel covalent inhibitors of KRAS<sup>G12C</sup> have shown limited response rates in patients with <i>KRAS</i><sup>G12C</sup>-mutant (MT) colorectal cancer. Thus, novel inhibitor combination strategies that can achieve deep and durable responses are needed. Small-molecule <i>KRAS</i><sup>G12C</sup> AZ’1569 AZ’8037 were used. To identify candidate for AZ’1569, we performed RNA sequencing, siRNA,...
<p>Supplementary materials and methods</p>
<p>antibodies</p>
<p>concentrations of drugs</p>
3557 Background: Novel covalent inhibitors of KRAS G12C have shown modest response rates in mutant (MT) colorectal cancer (CRC) patients. Thus, novel inhibitor combination strategies that can achieve deep and durable responses are needed. Methods: The small molecule AZ’1569 AZ’8037 were employed. To identify candidate for AZ’1569, we performed RNA sequencing, siRNA high-throughput drug screening. Top hits validated a panel MT CRC cells vivo xenograft models. acquired resistant models...