A5024094623- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Cancer Immunotherapy and Biomarkers
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Advanced Biosensing Techniques and Applications
- Protease and Inhibitor Mechanisms
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory Bowel Disease
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- Mycobacterium research and diagnosis
- Gut microbiota and health
- Biosensors and Analytical Detection
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Click Chemistry and Applications
- Immune Response and Inflammation
- Gene expression and cancer classification
- Optical Coherence Tomography Applications
The Wallace H. Coulter Department of Biomedical Engineering
2018-2025
Providence College
2022
Georgia Institute of Technology
2020-2022
Nokia (United States)
2022
Emory University
2021
Local delivery of a pro-resolving lipid mediator leads to shift in the immune microenvironment and improves wound healing.
Proteases are multi-functional enzymes that specialize in the hydrolysis of peptide-bonds and control broad biological processes including homeostasis allostasis. Moreover, dysregulated protease activity drives pathogenesis is a functional biomarker diseases such as cancer; therefore, ability to detect vivo may provide clinically relevant information for biomedical diagnostics. The goal this protocol create nanosensors probe by producing quantifiable signal urine. These consist two...
Abstract Immune checkpoint blockade (ICB) therapy has transformed cancer treatment, yet most patients do not derive clinical benefit and responders can acquire resistance to therapy. Noninvasive biomarkers are needed indicate early on-treatment response mechanisms. Here we developed I mmu N e S ensors for mon torinG c H eckpoint T herapy (INSIGHT), which comprises a library of mass-barcoded peptide substrates conjugated αPD1 antibodies, as therapeutic sensors. Following systemic...
Proteases are multi-functional enzymes that specialize in the hydrolysis of peptide-bonds and control broad biological processes including homeostasis allostasis. Moreover, dysregulated protease activity drives pathogenesis is a functional biomarker diseases such as cancer; therefore, ability to detect vivo may provide clinically relevant information for biomedical diagnostics. The goal this protocol create nanosensors probe by producing quantifiable signal urine. These consist two...
<h3>Background</h3> Despite the curative potential of immune checkpoint blockade (ICB) therapy, only small subsets patients achieve tumor regression while many responders relapse and acquire resistance. Monitoring treatment response detecting onset resistance are critical for improving patient prognoses. Here we engineered ICB antibody-sensor conjugates known as ICB-Dx by coupling peptides sensing activity granzyme B (GzmB), a T cell cytotoxic protease, directly on αPD1 antibody to monitor...
We developed a modular approach for biochemical sensing using aptamer-based microparticles and swept-source OCT. Tuning the crosslinker composition of microparticle enabled varying physicochemical responses to target biochemical, ranging from degradation reversible swelling, which was spatiotemporally monitored in tissue-mimics