A5048416186- Advanced NMR Techniques and Applications
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Electron Spin Resonance Studies
- Medical Imaging Techniques and Applications
- Enzyme Structure and Function
- Solid-state spectroscopy and crystallography
- NMR spectroscopy and applications
- Amino Acid Enzymes and Metabolism
- Protein Structure and Dynamics
- Lanthanide and Transition Metal Complexes
- Magnetism in coordination complexes
- MRI in cancer diagnosis
- Boron Compounds in Chemistry
- Radiomics and Machine Learning in Medical Imaging
- Nuclear Physics and Applications
- Sparse and Compressive Sensing Techniques
- Photoacoustic and Ultrasonic Imaging
- Stellar, planetary, and galactic studies
- Crystallography and Radiation Phenomena
- Redox biology and oxidative stress
- Neuroendocrine Tumor Research Advances
- Liver Disease Diagnosis and Treatment
- Mechanisms of cancer metastasis
- Nanoplatforms for cancer theranostics
University of California System
2016-2025
University of California, San Francisco
2016-2025
Bioengineering Center
2025
University of California, Berkeley
2024-2025
Neurological Surgery
2025
University of San Francisco
2024
Berry (United States)
2021-2022
Paul Hastings
2021
Laboratoire d’Imagerie Biomédicale
2020
University of Georgia
2008-2019
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTInstrumentation for Hydrogenative Parahydrogen-Based Hyperpolarization TechniquesAndreas B. Schmidt*Andreas SchmidtDepartment of Radiology−Medical Physics, Medical Center, Faculty Medicine, University Freiburg, Killianstraße 5a, Freiburg 79106, GermanyGerman Cancer Consortium (DKTK), partner site and German Research Center (DKFZ), Im Neuenheimer Feld 280, Heidelberg 69120, Germany*Email: [email protected]More by Andreas SchmidtView...
Purpose Hyperpolarized carbon‐13 ( 13 C) metabolic imaging is a noninvasive modality for evaluating real‐time metabolism. The purpose of this study was to develop and implement experimental strategies using [1‐ C]pyruvate probe in vivo metabolism patients with brain tumors other neurological diseases. Methods C radiofrequency coils pulse sequences were tested phantom performed 3 Tesla whole‐body scanner. Samples polarized SPINlab system. Dynamic data acquired from 8 previously diagnosed...
MRI using hyperpolarized (HP) carbon‐13 pyruvate is being investigated in clinical trials to provide non‐invasive measurements of metabolism for cancer and cardiac imaging. In this project, we applied HP [1‐ 13 C]pyruvate dynamic prostate measure the conversion from lactate, which expected increase aggressive cancers. The goal work was develop test analysis methods improved quantification metabolic conversion. work, compared specialized kinetic modeling estimate pyruvate‐to‐lactate rate, k P...
Abstract Background Hyperpolarized (HP) 13 C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate metabolism through glycolytic pathways in human prostate cancer. Heretofore this has been successfully utilized cancer only localized disease. This pilot clinical study investigated feasibility and performance HP MR metabolic patients with metastases to bone and/or viscera. Methods Six who had metastatic castration-resistant were recruited....
Abstract MRI with hyperpolarized (HP) 13 C agents, also known as HP MRI, can measure processes such localized metabolism that is altered in numerous cancers, liver, heart, kidney diseases, and more. It has been translated into human studies during the past 10 years, recent rapid growth largely based on increasing availability of agent preparation methods suitable for use humans. This paper aims to capture current successful practices [1‐ C]pyruvate—by far most commonly used agent, which sits...
To develop and translate a metabolite-specific imaging sequence using symmetric echo planar readout for clinical hyperpolarized (HP) Carbon-13 (13 C) applications.Initial data were acquired from patients with prostate cancer (N = 3) high-grade brain tumors on 3T scanner. Samples of [1-13 C]pyruvate polarized at least 2 h 5T SPINlab system operating 0.8 K. Following injection the HP substrate, pyruvate, lactate, bicarbonate (for studies) sequentially excited singleband spectral-spatial RF...
Abstract New magnetic resonance (MR) molecular imaging techniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a three-dimensional dynamic dual-agent hyperpolarized 13C spectroscopic approach with 13C-pyruvate 13C-urea to investigate differences metabolism between low- high-grade tumors transgenic adenocarcinoma mouse prostate (TRAMP) model cancer. Dynamic MR data were corrected T1 relaxation RF...
Purpose To develop symmetric echo planar imaging (EPI) and a reference scan framework for hyperpolarized 13 C metabolic imaging. Methods Symmetric, ramp‐sampled EPI with partial Fourier reconstruction was implemented on 3T scanner. The acquiring the 1 H channel applied to data described validated in both phantoms vivo metabolism of [1‐ C]pyruvate. Results Ramp‐sampled, provided substantial increase signal‐to‐noise ratio phantom experiments. acquired yielded images that varied mean signal...
BACKGROUND Optimal treatment selection for localized renal tumors is challenging because of their variable biologic behavior and limitations in the preoperative assessment tumor aggressiveness. The authors investigated emerging hyperpolarized (HP) 13 C magnetic resonance imaging (MRI) technique to noninvasively assess lactate production, which strongly associated with METHODS Eleven patients underwent HP pyruvate MRI before surgical resection. Tumor images were acquired dynamically. Five 2...
The availability of clinical-grade cytokines and artificial antigen-presenting cells has accelerated interest in using natural killer (NK) as adoptive cellular therapy (ACT) for cancer. One the technological shortcomings translating therapies from animal models to clinical application is inability effectively non-invasively track these after infusion patients. We have optimized nonradioactive isotope fluorine-19 (19F) a means label NK preclinical magnetic resonance imaging (MRI). Human were...
Purpose The purpose of this study was to develop a new 3D dynamic carbon‐13 compressed sensing echoplanar spectroscopic imaging (EPSI) MR sequence and test it in phantoms, animal models, then prostate cancer patients image the metabolic conversion hyperpolarized [1‐ 13 C]pyruvate C]lactate with whole gland coverage at high spatial temporal resolution. Methods A (CS)‐EPSI spectral–spatial excitation designed meet required coverage, time resolution, RF limitations 3T scanner for its clinical...
Hyperpolarized carbon-13 (HP-13C) MRI is a non-invasive imaging technique for probing brain metabolism, which may improve clinical cancer surveillance. This work aimed to characterize the consistency of serial HP-13C in patients undergoing treatment tumors and determine whether there evidence aberrant metabolism tumor lesion compared normal-appearing tissue. Serial dynamic HP [1-13C]pyruvate was performed on 3 healthy volunteers (6 total examinations) 5 (21 with diffuse infiltrating glioma...
Purpose The combined hyperpolarized (HP) 13 C pyruvate and urea MRI has provided a simultaneous assessment of glycolytic metabolism tissue perfusion for improved cancer diagnosis therapeutic evaluation in preclinical studies. This work aims to translate this dual‐probe HP imaging technique clinical research. Methods A co‐polarization system was developed where [1‐ C]pyruvic acid (PA) [ C, 15 N 2 ]urea water solution were homogeneously mixed polarized on 5T SPINlab system. Physical chemical...
Hyperpolarized 13 C MRI quantitatively measures enzyme-catalyzed metabolism in cancer and metabolic diseases. Whole-abdomen imaging will permit dynamic of several abdominal organs simultaneously healthy diseased subjects.Image hyperpolarized [1-13 C]pyruvate products the abdomens volunteers, overcoming challenges motion, magnetic field variations, spatial coverage. Compare across volunteers.Prospective technical development.A total volunteers (8 male), 21-64 years (median 36).A 3 T. Proton:...
This study aimed to develop and demonstrate the in vivo feasibility of a 3D stack-of-spiral balanced steady-state free precession(3D-bSSFP) urea sequence, interleaved with metabolite-specific gradient echo (GRE) sequence for pyruvate metabolic products, improving SNR spatial resolution first hyperpolarized 13 C-MRI human injection co-hyperpolarized [1-13 C]pyruvate [13 C,15 N2 ]urea.A bSSFP imaging was designed using urea-specific excitation pulse, optimized TR, readouts. Simulations phantom...
Kinetic modeling of the in vivo pyruvate-to-lactate conversion is crucial to investigating aberrant cancer metabolism that demonstrates Warburg effect modifications. Non-invasive detection alterations metabolic flux might offer prognostic value and improve monitoring response treatment. In this clinical research project, hyperpolarized [1-13C] pyruvate was intravenously injected a total 10 brain tumor patients measure its rate lactate ( kPL ) bicarbonate kPB via echo-planar imaging. Our aim...
ACES, one of Good's buffers, was applied to pH imaging with hyperpolarized<sup>13</sup>C spectroscopy.
Purpose To ameliorate tradeoffs between a fixed spatial resolution and signal‐to‐noise ratio (SNR) for hyperpolarized 13 C MRI. Methods In MRI, SNR is proportional to voxel volume but retrospective downsampling or averaging only improves by the square root of size. This can be exploited with metabolite‐selective imaging approach that independently encodes each compound, yielding high‐resolution images injected substrate coarser downstream metabolites, while maintaining adequate each. assess...
Abstract Based on the expanding set of applications for hyperpolarized carbon‐13 (HP‐ 13 C) MRI, this work aims to communicate standardized methodology implemented at University California, San Francisco, as a primer conducting reproducible metabolic imaging studies prostate and brain. Current state‐of‐the‐art HP‐ C acquisition, data processing/reconstruction kinetic modeling approaches utilized in patient are presented together with rationale underpinning their usage. Organized around...
Abstract Purpose X‐nuclei (also called non‐proton MRI) MRI and spectroscopy are limited by the intrinsic low SNR as compared to conventional proton imaging. Clinical translation of x‐nuclei examination warrants need a robust versatile tool improving image quality for diagnostic use. In this work, we compare novel denoising method with fewer inputs current state‐of‐the‐art method. Methods Denoising approaches were on human acquisitions sodium ( 23 Na) brain, deuterium 2 H) carbon 13 C) heart...
Purpose Acquisition timing and B 1 calibration are two key factors that affect the quality accuracy of hyperpolarized 13 C MRI. The goal this project was to develop a new approach using regional bolus tracking trigger Bloch‐Siegert mapping real‐time based on measurements, followed by dynamic imaging metabolites in vivo. Methods proposed implemented system which allows data processing control sequence. Real‐time center frequency upon arrival also added. feasibility applying framework for vivo...