A5028707549- Platelet Disorders and Treatments
- Complement system in diseases
- Transplantation: Methods and Outcomes
- Heparin-Induced Thrombocytopenia and Thrombosis
- Blood groups and transfusion
- Lymphoma Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Atrial Fibrillation Management and Outcomes
- Mechanical Circulatory Support Devices
- Dental Anxiety and Anesthesia Techniques
- Organ Transplantation Techniques and Outcomes
- Space exploration and regulation
- Sepsis Diagnosis and Treatment
- Dental Radiography and Imaging
- COVID-19 Clinical Research Studies
- Multiple Myeloma Research and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Transplantation Outcomes and Treatments
- Blood properties and coagulation
- Trypanosoma species research and implications
- Pancreatitis Pathology and Treatment
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
University of Liverpool
2020-2024
Aintree University Hospitals NHS Foundation Trust
2020-2024
National Health Service
2023
Royal Liverpool and Broadgreen University Hospital NHS Trust
2022
Clatterbridge Cancer Centre NHS Foundation Trust
2021
Microclots have been associated with various conditions, including postacute sequelae of severe acute respiratory syndrome coronavirus 2 infection. They postulated to be amyloid-fibrin(ogen) aggregates, but their role as a prognostic biomarker remains unclear. To examine possible clinical utility, blood samples were collected for the first 96 hours from critically ill patients (n = 104) admitted intensive care unit (ICU). Detection was by staining platelet-poor plasma thioflavin T and...
Abstract High-dose methotrexate (HD-MTX) is increasingly used as prophylaxis for patients with diffuse large B-cell lymphoma (DLBCL) at high risk of central nervous system (CNS) relapse. However, there limited evidence to guide whether intercalate HD-MTX (i-HD-MTX) between R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone given 21-day intervals) or give it the end treatment (EOT) R-CHOP-21. We conducted a retrospective, multicenter analysis 334 DLBCL who...
Acute thrombosis and thrombocytopenia pose challenges to the clinician. Thrombocytopenia is naturally viewed as a risk factor for bleeding, an association with acute appears paradoxical. It presents typically medical emergency requires treatment be started before having confirmatory results. This review supports attending clinician recognise manage conditions that are part of thrombotic thrombocytopenic syndrome through four illustrative clinical cases. Common themes linking underlying...
Adenoviral vector-based COVID-19 vaccine-induced immune thrombotic thrombocytopenia (VITT) is rare but carries significant risks of mortality and long-term morbidity. The underlying pathophysiology severe disease still not fully understood. objectives were to explore the pathophysiological profile examine for clinically informative biomarkers in patients with VITT.
By causing inflammation and tissue damage, neutrophil extracellular traps (NETs) constitute an underlying mechanism of aspiration-induced lung injury, a major factor the low utilization donor lungs in transplantation (LTx).
A 44-year-old woman with refractory plasma cell leukaemia (PCL) develops new-onset tonic-clonic seizures, having only recently completed four cycles of intensive combination chemotherapy Bortezomib, Cisplatin, Cyclophosphamide, Dexamethasone, Doxorubicin, Etoposide, and Thalidomide. Urgent non-contrast computed tomography scan the head was unremarkable. Cerebrospinal fluid sampling revealed florid infiltration, occasional mitotic forms plasmablasts seen (Figure 1A, 50x oil immersion...