A5082523488- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Photoacoustic and Ultrasonic Imaging
- Hydrogels: synthesis, properties, applications
- Conducting polymers and applications
- Lipid Membrane Structure and Behavior
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Analytical Chemistry and Sensors
- Advanced MRI Techniques and Applications
- Advanced Nanomaterials in Catalysis
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Glycosylation and Glycoproteins Research
- Advancements in Transdermal Drug Delivery
Freie Universität Berlin
2018-2021
We analyzed the protein corona of thermoresponsive, poly(N-isopropylacrylamide)- or poly(N-isopropylmethacrylamide)-based nanogels.Traces detected after incubation in human serum were characterized by proteomics and dynamic light scattering undiluted serum.Apolipoprotein B-100 albumin main components coronae. For dendritic polyglycerol-poly(N-isopropylacrylamide) nanogels at 37°C, an increase adsorbed immunoglobulin chains was detected, followed partially reversible nanogel aggregation. All...
Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and functional imaging, (nano)molecular probing in an integrated RF applicator. This study examines the feasibility of ThermalMR for controlled release a model therapeutics from thermoresponsive nanogels using 7.0-tesla whole-body MR scanner en route to local drug-delivery-based anticancer treatments. The capacity is demonstrated system involving fluorescein-labeled...
Abstract Mucosal surfaces pose a challenging environment for efficient drug delivery. Various delivery strategies such as nanoparticles have been employed so far; yet, still yielding limited success. To address the need of transmucosal delivery, this report presents synthesis novel disulfide‐containing dendritic polyglycerol (dPG)‐based nanogels and their preclinical testing. A bifunctional linker is coupled to dPG act macromolecular crosslinker poly‐ N ‐isopropylacrylamide (PNIPAM)...