Lycopene (LYC) is a carotenoid, has antioxidant properties. This study investigated whether lycopene attenuates aristolochic acids (AAs) -induced chronic kidney disease. In this experiment, was used to intervene C57BL/6 mice with renal injury induced by acid exposure. The histomorphological changes and serological parameters of the were measured in order assess alleviating effect on nephropathy. vitro vivo experiments carried out verify main mechanism action drug targets improving...

Nob mice share the same mutation in Nyx gene that is found humans with complete congenital stationary night blindness (CSNB1). mutant were studied to determine whether this defect resulted myopia, as it does humans.Refractive development was measured unmanipulated wild-type C57BL/6J (WT) and nob from 4 12 weeks of age by using an infrared photorefractor. The right eye form deprived means a skull-mounted goggling apparatus at age. Refractive errors recorded every 2 after goggling. content...

Trimethyltin chloride (TMT) is a highly toxic organotin compound often used in plastic heat stabilizers, chemical pesticides, and wood preservatives. TMT accumulates mainly through the environment food chain. Exposure to compounds associated with disorders of glucolipid metabolism obesity. The mechanism by which damages pancreatic tissue unclear. For this purpose, subacute exposure model was designed for experiment study damage on islet. fasting blood glucose lipid content mice exposed were...

Abstract Architecture and music have a potential to trigger similar psychological effects in people due commonalities artistic structural properties. Current studies exploring the relationship between architecture often focused on analyzing how can inspire architectural design, but there been lack of such context. Therefore, this study adopts semiotics analogy as an interdisciplinary approach aiming comprehensively investigate connections music, particularly terms design forms organization...

An insulin delivery system that self-regulates blood sugar levels, mimicking the human pancreas, can improve hyperglycaemia. At present, a glucose-responsive combining AAPBA with long-acting slow release biomaterials has been developed. However, safety of sustained-release materials and challenges preventing diabetic complications remain. In this study, we developed novel polymer material using plant extract-p-hydroxyphenylethyl anisate (HPA). After block copolymerisation AAPBA, prepared...

Background: The recurrence and mortality rates of bladder cancer are extremely high, its diagnosis treatment global concerns. mechanism anoikis is closely related to tumor metastasis.

Oat is a food and forage crop species widely cultivated worldwide, it also an important grass in plateau regions of China, where there high level ultraviolet radiation sunlight. Screening suitable reference genes for oat under UV-B high-light stresses prerequisite ensuring the accuracy real-time quantitative PCR (qRT–PCR) data used plant adaptation research. In this study, eight candidate (sulfite oxidase, SUOX; victorin binding protein, VBP; actin-encoding, Actin1; protein PSK SIMULATOR...

Abstract Background One major mission of microbial breeding is high-level production desired metabolites. Overproduction intermediate metabolites in core pathways challenging as it may impair cell growth and viability. Results Here we report that aconitic acid, an metabolite tricarboxylic acid (TCA) cycle, can be overproduced by engineered CRISPR interference (CRISPRi) system Escherichia coli . This CRISPRi was designed to simultaneously target pyruvate kinase (PK) isocitrate dehydrogenase...

purpose. The adenine nucleotide transporter 1 gene (ANT1) encodes an inner mitochondrial membrane protein that transports ATP into the cell. Mutations within ANT1 produce a syndrome of chronic progressive external ophthalmoplegia (CPEO) in humans. Ant1 knockout (Ant1 −/−) mice develop cardiomyopathy and myopathy limb muscles. Because extraocular muscles (EOM) are preferentially affected human CPEO, objective this study was to determine whether −/− also exhibit EOM myopathy. methods. ANT...

Complex oxide heterointerfaces provide a platform to manipulate spin–orbit coupling under the broken inversion symmetry. Moreover, their weak antilocalization (WAL) effect displays quantum coherent behavior due strong coupling. Herein, we break through limitation of lattice mismatch at ReAlO3/STO (Re = La, Pr, Nd, Sm, and Gd) obtain two-dimensional electric gas (2DEG) by spin coating. The different Re elements in resulting corrections on conductivity is investigated. It observed that reduced...

The two-dimensional electron gas at the interfaces of insulating oxides has been one hot issues contributing to development all-oxide devices. introduced buffer layer will produce some strange physical properties due broken space-reversal symmetry. Here, we investigate electronic transport property heterointerfaces by introducing layers lanthanum cobaltate with different thicknesses. It is found that show a metal-to-insulator transition, and mobility enhanced more than 1 order magnitude upon...

Abstract Background The combination of metal-catalyzed reactions and enzyme catalysis has been an essential tool for synthesizing chiral pharmaceutical intermediates in the field drug synthesis. Metal commonly enables highly efficient synthesis molecular scaffolds under harsh organic conditions, whereas enzymes usually catalyze mild aqueous medium to obtain high selectivity. Since incompatibility between metal catalysis, there are limitations on compatibility reaction conditions that must be...

Application of multifunctional integrated devices represents a main trend in the future. However, it is still great challenge to realize ferroelectric metals single system. Here, we report coexistence metallicity and ferroelectricity-like polarization at GdAlO3/SrTiO3 heterointerfaces. The results show that asymmetric bistable GdAlO3 film attributed spontaneous oxygen vacancies. Furthermore, transport property heterointerfaces can be significantly manipulated by switching state. It observed...

This work constructs high-entropy oxide interfaces by double doping with a high ratio and different thicknesses, various phenomena are studied.

Dragon's blood is a natural medicine with hemostatic and blood-activating effects used to promote wound healing. Dracorhodin perchlorate (DP) stable form of dracarhod as substitute for cochinchinenin. DP promotes the proliferation rat fibroblasts healing in rats.DP ointment (0.2 mg/mL) was applied skin wounds nondiabetic diabetic rats, collected. Wound rate, H&E staining, Masson TLR4 pathway, related inflammatory factors, nitric oxide synthase, so forth were detected.DP treatment alleviated...

Complex oxide heterointerfaces have been a hot research spot due to their rich physical phenomena and broad quantum coherence that respond multiple external stimuli. Among these stimuli, light is very powerful one manipulate properties such as carrier density spin characteristics. However, achieving light–magnetic correlation in high demand for multifield responding devices, its intrinsic mechanism remains unclear. Here, by illuminating Nd0.86Sr0.14Al0.86Ni0.14O3-SrTiO3 using 360 nm light,...

The two-dimensional electron gas (2DEG) residing at complex oxide interfaces has been drawing considerable interests due to its abundant physical characteristics. Moreover, it exhibits a response towards diverse external stimuli and correlation among different freedoms, like spin, lattice, orbital charge, etc. most studied objects are SrTiO 3 (STO) KTaO (KTO)-based heterointerfaces (HIs), which fully utilize their [Formula: see text]-orbital On the other hand, oxides may also have enough...