A5087444350- MicroRNA in disease regulation
- Phytochemistry and Biological Activities
- Advanced Nanomaterials in Catalysis
- Circular RNAs in diseases
- Cardiac Valve Diseases and Treatments
- Medicinal Plants and Neuroprotection
- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Malaria Research and Control
- Dye analysis and toxicity
- Pharmacology and Nanomedicine Research
- Tryptophan and brain disorders
- Cardiovascular Function and Risk Factors
- Nanoparticles: synthesis and applications
- Biosensors and Analytical Detection
- Traditional Chinese Medicine Analysis
- Hepatitis B Virus Studies
- Cholinesterase and Neurodegenerative Diseases
- Digestive system and related health
- Diverse Scientific Research Studies
- Antimicrobial agents and applications
- Research on Leishmaniasis Studies
- Computational Drug Discovery Methods
- Livestock and Poultry Management
- FOXO transcription factor regulation
Kohat University of Science and Technology
2020-2025
Bacha Khan University
2024
Quaid-i-Azam University
2012-2021
Background. Valvular heart disease (VHD) is a major contributor to loss of physical function and longevity. Oxidative stress one the key causative factors involved in including VHD. Here, we aimed illuminate role relation oxidative VHD risk markers human population. Materials Methods. 150 patients 103 healthy individuals as control were selected for study divided into three groups: aortic valve, mitral combined based on valvular calcification. Results. Our results demonstrated enhanced...
Zinc oxide nanoparticles (ZnO NPs) are becoming an innovative agent in biological and environmental applications due to its unique characteristics, biocompatibility, low cost toxicity. In this study, the composite ZnO NPs using Rhododendron arboreum (R. arboreum) stem bark were synthesized characterized for UV–visible spectroscopy (UV-vis), Fourier transform infrared (FTIR), energy dispersive X-ray (EDX), scanning electron microscopy (SEM), diffraction (XRD). The biomedical assessment of...
Abstract Background Dengue fever has become a significant worldwide health concern, because of its high morbidity rate and the potential for an increase in mortality rates due to lack adequate treatment. There is immediate need development effective medication dengue fever. Methods Homology modeling virus (DENV) non-structural 4B (NS4B) protein was performed by SWISS-MODEL predict 3D structure protein. Structure validation conducted using PROSA, PROCHECK, Ramachandran plot, VERIFY-3D. MOE...
Abnormal levels of ascorbic acid in the human body can induce various diseases. We reported a nickel-doped hydroxyapatite (Ni-HAp)-based biosensor for and confirmed it through spectroscopic techniques. Ni-HAp demonstrated peroxidase-like activity that was detected chromogenic substrate. The analyte produces color change from blue-green to colorless. optimized sensor has correlation coefficient 0.997, limit detection 0.11 µM, quantification value 0.36 linear range 2 47 µM acid. synthesized...
Zinc nanoparticles (ZnNPs) open new opportunities for biomedical applications as a strategy against microbes and dye removal in an efficient way. The composite ZnNPs using Rhododendron arboreum (R. arboreum) stem bark were synthesized characterized UV-visible spectroscopy (UV-vis), Fourier transform infrared (FTIR), energy dispersive X-ray (EDX), scanning electron microscopy (SEM), diffraction (XRD). showed zones of inhibition 23±0.09, 18±0.1 16±0.05 mm, the...
SARS-CoV-2 infection affects and modulates serum as well hematological parameters. However, whether it modifies these parameters in the existing disease conditions, which help erection of specific treatments for disease, is under investigation. Here, we aimed to determine alteration various diseases, diabetes mellitus (DM), hypertension (HTN), ischemic heart (IHD) myocardial infarction (MI) conditions correlate signal infection, could be used a rapid diagnosis tool conditions. To assess...
Hyperlipidemia is an identified risk factor for metabolic syndrome, obesity and cardiovascular complications characterized by elevated levels of lipids in blood. The present study aimed to inhibit HMG-CoA reductase with 15-oxoursolic acid through in-vivo in-silico assessments. HFD-induced hyperlipidemia rats was developed a marked increase total cholesterol (58.34 ± 0.21 mg/dl), triglycerides (45.45 0.39 LDL-c (66.12 0.10 VLDL-c (19.34 0.16 decrease HDL-c (10.34 0.18 mg/dl). oral...
Zinc nanoparticles (ZnNPs) open new opportunities for biomedical applications as a strategy against microbes and dye removal in an efficient way. The composite ZnNPs using Rhododendron arboreum (R. arboreum) stem bark were synthesized characterized UV-visible spectroscopy (UV-vis), Fourier transform infrared (FTIR), energy dispersive X-ray (EDX), scanning electron microscopy (SEM), diffraction (XRD). showed zones of inhibition 23±0.09, 18±0.1 16±0.05 mm, the...
In this study, green synthesis of gold nanoparticles (AuNPs) using aqueous extract from Hymenaea courbaril resin (HCR) is reported. The successful formation, functional group involvement, size, and morphology the subject H. mediated (HCRAuNPs) were confirmed by Ultra Violet-Visible (UV-vis) spectroscopy, Fourier-Transform Infrared spectroscopy (FTIR), Transmission Electron Microscopy (TEM) techniques. Stable high yield HCRAuNPs was formed in 1:15 (aqueous solution: salt solution) reacted...
Malaria is one of the serious diseases threatening human health in Pakistan and contributes to a large proportion total malaria deaths South Asia. However, little known about nature extent genetic diversity malarial parasites circulating Pakistan. This study was designed assess infection status Plasmodium vivax falciparum by analyzing msp-3α, msp-3β msp-1, msp-2 genes respectively using allele specific nested PCR RFLP assays. For this purpose, 130 field isolates were collected from...
Bacterial resistance to antibiotics and host defense systems is primarily due bacterial biofilm formation in antibiotic therapy. In the present study, two complexes, bis (biphenyl acetate) bipyridine Cu (II) (1) Zn (2), were tested for their ability prevent formation. The minimum inhibitory concentration bactericidal of complexes 1 2 46.87 ± 1.822 93.75 1.345 47.87 94.85 1.466 μg/mL, respectively. significant activity both was attributed damage caused at membrane level confirmed using an...
The study reports on synthesis of aqueous extract mediated gold and silver nanoparticles M. biflora (MBAuNPs MBAgNPs) via hydrated chloroauric acid nitrate salts. (NPs) were produced in 1:15 (MBAuNPs) 1:6 (MBAgNPs) ratios under sunlight displaying localized surface plasmon resonance (LSPR) peaks at 541 431 nm, respectively. sizes characterized by transmission electron, scanning atomic force microscopic (SEM, TEM, AFM) techniques respectively 26.73 nm 53.81 nm. subject NPs demonstrated...
Data is about the mitochondrial apoptosis regulatory framework genes PUMA, DRP1 (apoptotic), and ARC (anti-apoptotic) analysis after employment of their controlling miRNAs inhibitors. The data represents putative conserved targeting seed regions miR-15a, miR-29a, miR-214 with respective target DRP1, ARC. cross interference in expression levels one miRNA family, miR-29a its upon inhibitory treatment other 15a 214.
To evaluate the concentration of N terminal proBNP (NT-proBNP) and partially serum uric acid in severe condition aortic valve dysfunction for assessment left ventricle hypertrophy.The study was conducted signal transduction lab department biochemistry Quaid-I-Azam University, Islamabad from September 2013 to February 2017. NT-proBNP were measured one hundred patients dysfunction. The divided into three main groups: 1) Aortic stenosis, 2) regurgitation, 3) stenosis with regurgitation. results...
Background Chronic valvular heart disease leads to systolic dysfunction and left atrial enlargement that ultimately results in failure. Purpose To investigate prognostic importance of Echocardiography plasma natriuretic peptide levels increase as a compensatory response can be used predictive markers for cardiac hypertrophy. Material Methods The patients were divided into three groups: 51 with ventricle hypertrophy due aortic valve disease; 126 mitral dysfunction; 76 both conditions. Atrial...
Abstract The aim of the current study was to evaluate therapeutic potentials Hydroxyquinoline Sulfanilamide (HSM) for Alzheimer’s disease in a mice model Streptozotocin (STZ)-induced diabetes. antioxidant analysis brain homogenates carried out by catalase (CAT) assay, reduced glutathione (GSH) and lipid peroxidation (LPO) assay. Biochemical blood plasma conducted peroxidase (POD) assay superoxide dismutase (SOD) expression proteins evaluated using Western Blotting analysis. administration...
It is important to develop new antibacterial drugs since the emergence of bacterial resistance available antibiotics. Metal nanoparticles have potential combat antibiotic and are effective agents. Here, we demonstrate biogenic production zinc using Rhododendron arboreum stem bark. The biosynthesized ZnNPs were characterized through different analytical techniques such as UV-vis, FTIR, EDX, SEM, XRD. Clinical isolates E. coli, S. aureus, K. pneumonia used check efficacy nanoparticles. MIC MBC...
Hyperlipidemia is an identified risk factor for metabolic syndrome and cardiovascular complications characterized by elevated levels of lipids in blood. The present study aimed to inhibit HMG-CoA reductase with 15-oxoursolic acid through in-vivo in-silico assessments. HFD-induced hyperlipidemia rats was developed a marked increase total cholesterol (58.34 ± 0.21 mg/dl), triglycerides (45.45 0.39 LDL-c (66.12 0.10 VLDL-c (19.34 0.16 decrease HDL-c (10.34 0.18 mg/dl). oral administration at...
In this study, green synthesis of gold nanoparticles using aqueous solution resin from Hymenaea courbaril (HCRAuNPs) is reported. The successful formation, functional group involvement, size, and morphology the subject HCRAuNPs was confirmed by UV-Visible, FT-IR, TEM (transmission electron microscopy) spectroscopic techniques. Stable high yield formed in 1:15 (aqueous solution: salt solution) reacted sunlight as indicated visual colour change appearance surface Plasmon resonance (SPR) at 560...