A5100624488- PI3K/AKT/mTOR signaling in cancer
- Aquatic Ecosystems and Phytoplankton Dynamics
- Biocrusts and Microbial Ecology
- Advanced Fiber Laser Technologies
- Evolutionary Game Theory and Cooperation
- Microtubule and mitosis dynamics
- Chinese history and philosophy
- Photonic Crystal and Fiber Optics
- Solid State Laser Technologies
- Forest, Soil, and Plant Ecology in China
- Synthesis and Reactions of Organic Compounds
- China's Ethnic Minorities and Relations
- Remote Sensing and Land Use
- RNA Research and Splicing
- Neurological disorders and treatments
- Laser-Matter Interactions and Applications
- Functional Brain Connectivity Studies
- Advanced Thermodynamics and Statistical Mechanics
- Organoselenium and organotellurium chemistry
- Reproductive Physiology in Livestock
- Environmental and Agricultural Sciences
- Evolution and Genetic Dynamics
- Synthesis and biological activity
- Reproductive System and Pregnancy
- CRISPR and Genetic Engineering
Capital Medical University
2023-2025
Chengdu Women's and Children's Central Hospital
2025
Chengdu Medical College
2025
National Institute of Metrology
2024
Center for Systems Biology Dresden
2024
Max Planck Institute of Molecular Cell Biology and Genetics
2024
Institute of Disaster Prevention
2024
Shenyang Agricultural University
2021-2022
Changchun Institute of Biological Products
2022
Qiqihar Medical University
2022
Mutualisms between species play an important role in ecosystem function and stability. However, some environments, the competitive aspects of interaction may dominate mutualistic aspects. Although these transitions could have far-reaching implications, it has been difficult to study causes consequences this mutualistic-competitive transition experimentally tractable systems. Here, we a microbial cross-feeding mutualism which each yeast strain supplies essential amino acid for its partner...
We demonstrated an all-normal-dispersion Yb-doped mode-locked fiber laser based on Bi₂Se₃ topological insulator (TI). Different from previous TI-mode-locked lasers in which TIs were mixed with film-forming agent, we used a special way to paste well-proportioned pure TI end-facet. In this way, the effect of agent could be removed, thus heat deposition was relieved and damage threshold improved. The modulation depth film measured 5.2%. When laser, mode locked pulses pulse energy 0.756 nJ,...
To improve the ecological conditions, Chinese government adopted six large-scale restoration programs including 'Three-North Shelterbelt Project', "Grain for Green Project" and "Beijing-Tianjin Sand Source Control Project". Meanwhile, these ecologically vulnerable areas have experienced frequent droughts. However, little attention has been paid to impact of drought on effectiveness programs. Taking Beijing-Tianjin Region (BTSSR) as study area, we investigated role droughts program trends...
Cortical condensates, transient punctate-like structures rich in actin and the nucleation pathway member Neural Wiskott-Aldrich syndrome protein (N-WASP), form during activation of cortex Caenorhabditis elegans oocyte. Their emergence spontaneous dissolution is linked to a phase separation process driven by chemical kinetics. However, mechanisms that drive onset cortical condensate formation near membranes remain unexplored. Here, using reconstituted assay proteins, we demonstrate key...
The conflict between economic development and ecological protection continues to intensify, highlighting the necessity for constructing regional security patterns (ESPs) reconcile relationship effectively. This study used GMOP PLUS model simulate future land use changes by 2030 under following three scenarios: natural (ND), (EP), (ED). Employing MSPA circuit theory, it identified source areas constructed ESP Beijing–Tianjin–Hebei urban agglomeration (BTH) from 2000 2030. results indicate...
ABSTRACT Microcystin‐LR (MC‐LR), a potent specific hepatotoxin produced by cyanobacteria, has recently been reported to show neurotoxicity. Our previous study demonstrated that MC‐LR caused the reorganization of cytoskeleton architectures and hyperphosphorylation cytoskeletal‐associated proteins tau HSP27 in neuroendocrine PC12 cell line direct PP2A inhibition indirect p38 mitogen‐activated protein kinase (MAPK) activation. It shown oxidative stress is extensively associated with toxicity,...
Significance Topological defects are robust particle-like structures that essentially determine the mechanics and dynamics of physical biological matter. Examples range from vortices in quantum superfluids to cores spiral wave patterns brain. In systems, such play important roles as organizers biochemical signaling patterns, cellular forces, even cell death. Combining direct experimental observations with mathematical modeling chemical perturbations, we investigated on surfaces starfish egg...
Studies have indicated that epidural analgesia increases the risk of maternal fever during labor, possibly due to non-infectious inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a crucial indicator inflammation, with higher NLR potentially signaling worse patient adverse outcomes. present study explores whether has clinical predictive value for analgesia-related (ERMF). A retrospective analysis was performed 1602 women who voluntarily requested labor from January 2023 June 2024....
The identification of epileptic lesions is crucial for improving surgical outcomes. Nevertheless, substantial focal cortical dysplasia (FCD) may be invisible on magnetic resonance imaging (MRI). We aimed to characterize the expression pattern 18-kDa translocator protein (TSPO) in FCD and evaluate effectiveness this inflammation-reflective molecular technique detecting FCD. Patients clinically diagnosed with FCD, based clinical features, interictal electroencephalographic (EEG) findings, MRI...
Organ injury triggers non-neuronal electric currents essential for regeneration. Yet, the mechanisms by which electrical signals are generated, sensed and transmitted upon damage to promote organ growth remain unclear. Here, we uncover that regeneration relies on dynamic electrochemical coupling between tissue-wide depolarization intracellular proliferative signalling. By sub-second live imaging of injured zebrafish larval fins, identify events across timescales: a millisecond tissue...
A Q-switched Yb:KGW solid-state laser using topological insulator Bi2Se3 as a saturable absorber was demonstrated experimentally for the first time. The fabricated in film on highly reflective mirror. By inserting this into laser, operation obtained. highest average output power 439.4 mW and corresponding repetition rate, pulse width energy were 166.7 kHz, 1.6 μs 2.64 μJ, respectively. To our knowledge, is among insulator-modulated lasers with absorbers.
Polo-like kinase 1 (Plk1), a serine/threonine protein normally expressed in mitosis, is frequently up-regulated multiple types of human tumors regardless the cell cycle stage. However, causal relationship between Plk1 up-regulation and tumorigenesis incompletely investigated. To this end, using conditional expression system, here we generated transgenic mouse lines to examine role tumorigenesis. overexpression embryonic fibroblasts prepared from mice led aberrant mitosis followed by...
Abstract Ribosomal protein L34 (RPL34), belonging to the L34E family of ribosomal proteins, was reported be dysregulated in several types cancers and plays important roles tumor progression. However, expression RPL34 human glioma remain largely unknown. Thus, objective this study investigate role glioma. We report here that is highly expressed tissues cell lines. Knockdown markedly inhibited proliferation, migration, invasion, as well prevented epithelial‐mesenchymal transition phenotype...
Our previous studies have described the toxic effects of microcystin-LR (MC-LR) in various normal cell lines and human hepatoma SMMC-7721 cells, but specific MC-LR other types cancer cells with respect to protein phosphatase 2A (PP2A) not been fully elaborated. A549 lung adenocarcinoma identified express organic anion-transporting polypeptides (OATP) involved cellular uptake MC-LR, thus probably make an appropriate vitro model assess MC-LR's cytotoxicity. Hence, our present study, were...
The major toxic mechanism of Microcystin-LR is inhibition the activity protein phosphatase 2A (PP2A), resulting in a series cytotoxic effects. Our previous studies have demonstrated that microcystin-LR (MCLR) induced very different molecular effects normal cells and tumor cell line SMMC7721. To further explore MCLR toxicity cells, human laryngeal epithelial (Hep-2) was examined this study. Western blot, immunofluorescence, immunoprecipitation, transwell migration assay were used to detect on...
Cortical condensates, transient punctate-like structures rich in actin and the nucleation pathway member N-WASP, form during activation of cortex C. elegans oocyte. Their emergence spontaneous dissolution is linked to a phase separation process driven by chemical kinetics. However, physical that drives onset cortical condensate formation near membranes remains unexplored. Here, using reconstituted assay proteins, we demonstrate key component, can collectively undergo surface condensation on...
The AKT/TSC/mTOR axis is an important pathway controlling cell growth, survival, and proliferation in response to extracellular cues. Recently, it was reported that AKT activity fluctuates across the cycle. However, remains unclear whether downstream targets of are also regulated by Here, we report mTORC1 inversely correlates with during Mechanistically, Plk1 phosphorylation TSC1 at S467 S578 interfered TSC1/TSC2 binding, destabilized TSC1, promoted dissociation TSC complex from lysosome,...