A5013587392- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- Childhood Cancer Survivors' Quality of Life
- Family and Disability Support Research
- Mental Health and Patient Involvement
- Eosinophilic Disorders and Syndromes
- Inflammatory Bowel Disease
- Inflammasome and immune disorders
- Asthma and respiratory diseases
- Trace Elements in Health
- Healthcare innovation and challenges
- Drug-Induced Adverse Reactions
- Interprofessional Education and Collaboration
- Rheumatoid Arthritis Research and Therapies
- Mast cells and histamine
- Autoimmune and Inflammatory Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Orthopedic Infections and Treatments
- Urticaria and Related Conditions
University Medical Center Utrecht
2016-2023
Wilhelmina Children's Hospital
2018-2021
Utrecht University
2018
St. Antonius Ziekenhuis
2013-2015
Roosevelt University
2013
Roosevelt Institute for American Studies
2012-2013
Infliximab is effective as a third-line therapeutic for severe sarcoidosis; however, long-term efficacy unknown. The aim of this study was to assess the relapse rate after discontinuation infliximab in sarcoidosis patients and predict by analysis activity marker soluble interleukin (IL)-2 receptor (sIL-2R) maximum standardised uptake value (SUVmax) (18)F-fluorodeoxyglucose positron emission tomography (FDG PET). In retrospective cohort study, proportion analysed using Kaplan-Meier method...
Objective Human leukocyte antigen (HLA)‐DRB1*15:01 has been recently associated with interstitial lung disease (LD), eosinophilia, and drug reactions in systemic juvenile idiopathic arthritis (sJIA). Additionally, genetic variants IL1RN have linked to poor response anakinra. We sought reproduce these findings a prospective cohort study of patients new‐onset sJIA treated anakinra as first‐line therapy. Methods HLA risk alleles were identified via whole‐genome sequencing. Treatment responses...
Neutrophils are the most abundant innate immune cells in blood, but little is known about their role (acquired) chronic autoinflammatory diseases. This study was undertaken to investigate of neutrophils systemic-onset juvenile idiopathic arthritis (JIA), a prototypical multifactorial disease that characterized by and severe systemic inflammation.Fifty patients with JIA who were receiving treatment recombinant interleukin-1 receptor antagonist (rIL-1Ra; anakinra) analyzed at onset during...
Summary Sarcoidosis is a systemic granulomatous disease of unknown aetiology that most commonly affects the lungs. Although elevated levels regulatory T cells (Tregs) have been reported, extent to which they play role in sarcoidosis pathogenesis remains unclear. Tumour necrosis factor (TNF) thought be one driving forces behind granuloma formation, illustrated by efficacy infliximab severe sarcoidosis. Tregs express TNF receptor 2 (TNFR2) highly. Here, we examined influence therapy on and...
The aim of this qualitative study is to understand the research priorities Dutch children with juvenile idiopathic arthritis (JIA) as well researching how can be involved.Several health agendas have successfully been developed adults but rarely children. Children are still seldom recognized possessing credible knowledge about their own body and life. This project focus group discussions interviews was an innovative addition a nationwide prioritization questions patients JIA, carers care...
Abstract Background Involving the end-users of scientific research (patients, carers and clinicians) in setting priorities is important to formulate questions that truly make a difference are tune with needs patients. We therefore aimed generate national agenda for Juvenile Idiopathic Arthritis (JIA) together patients, their caregivers healthcare professionals through conducting nationwide survey among these stakeholders. Methods The James Lind Alliance method was used, tailored additional...
Abstract Background The James Lind Alliance (JLA) offers a method for research priority setting with patients, clinicians and carers. is increasingly used but publications primarily discuss the outcome of such projects, rather than reflecting on JLA itself. Scrutiny crucial in order to understand correctly interpret its outcomes. Methods We conducted qualitative interview study people involved project into Juvenile Idiopathic Arthritis (JIA) ( n = 30) better mechanisms, procedures decisional...
<h3>Background</h3> Research on Juvenile Idiopathic Arthritis (JIA) should have the primary goal to ultimately improve lives of affected patients, and help health professionals provide best care for them. Therefore, these end users research evidence – carers (parents/caregivers) clinicians be included in process identifying priorities. Importantly, patients can use their unique experiential knowledge from living with disease give vital input researchers designing a study. Combining this...
Abstract Background: Involving the end-users of scientific research (patients, carers and clinicians) in setting priorities is important to formulate questions that truly make a difference are tune with needs patients. We therefore aimed generate national agenda for Juvenile Idiopathic Arthritis (JIA) together patients, their caregivers healthcare professionals through conducting nationwide survey among these stakeholders. Methods: The James Lind Alliance method was used, tailored additional...
Abstract Background Involving the end-users of scientific research (patients, carers and clinicians) in setting priorities is important to formulate questions that truly make a difference are tune with needs patients. We therefore aimed generate national agenda for Juvenile Idiopathic Arthritis (JIA) together patients, their caregivers healthcare professionals through conducting nationwide survey among these stakeholders. Methods The James Lind Alliance method was used, tailored additional...