A5004367476- Salivary Gland Disorders and Functions
- Galectins and Cancer Biology
- Cardiovascular Health and Disease Prevention
- Blood Pressure and Hypertension Studies
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Obstructive Sleep Apnea Research
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Salivary Gland Tumors Diagnosis and Treatment
- Cardiovascular Disease and Adiposity
- Health and Medical Education
- Oral and Maxillofacial Pathology
- Inflammasome and immune disorders
- Cardiovascular Syncope and Autonomic Disorders
- Bone Tumor Diagnosis and Treatments
- Proteoglycans and glycosaminoglycans research
- Cellular transport and secretion
- Barrier Structure and Function Studies
- Empathy and Medical Education
- Higher Education Teaching and Evaluation
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Genetic Syndromes and Imprinting
- Sodium Intake and Health
- Immune Response and Inflammation
National Autonomous University of Honduras
2025
Universidad Mayor
2016-2025
Xiangya Hospital Central South University
2025
Central South University
2025
Universidad de Los Andes, Chile
2021-2024
Hospital Universitario Austral
2010-2024
Consorci Sanitari Garraf
2023
Centre Hospitalier Universitaire de Nîmes
2020
Hospital Alemán
2008-2018
Instituto Universitario de la Policía Federal Argentina
2015-2017
Tight junctions, the most apical of intercellular junctions that connect individual cells in a epithelial sheet, are thought to form seal restricts paracellular and intramembrane diffusion. To analyze functioning tight we generated stable MDCK strain 2 cell lines expressing either full-length or COOH-terminally truncated chicken occludin, only known transmembrane component junctions. Confocal immunofluorescence immunoelectron microscopy demonstrated mutant occludin was incorporated into but,...
Altered homeostasis of salivary gland (SG) epithelial cells in Sjögren's syndrome (SS) could be the initiating factor that leads to inflammation, secretory dysfunction and autoimmunity. Autophagy is an important homeostatic mechanism, whose deficiency associated with inflammation accumulation Janus kinase (JAK)-signal transducer activator transcription (STAT) components. We aimed evaluate whether autophagy altered labial SG (LSG) from primary SS (pSS) patients this contributes through...
Abstract Objective Acinar cells in the salivary glands of patients with Sjögren's syndrome (SS) display severe alterations anchorage to basal lamina. Bioinformatics analysis BP230 gene sequence has revealed presence CpG islands that might be involved epigenetic control expression, and methylation promotor region may implicated as an mechanism gland damage. Thus, present study was undertaken evaluate protein BP230, well proteins BP180, α6β4 integrin, cytokeratin‐18, for their expression...
A hallmark characteristic of SS patients is the ectopic presence mucins MUC5B and MUC7 in extracellular matrix salivary glands that have lost apical-basolateral acinar-cell polarity. This study aims to determine whether exogenous induce gene expression pro-inflammatory cytokines, as well evaluate Toll-like receptor-4 (TLR4) pathway involved this response.Differentiated human submandibular gland (HSG) cells were stimulated with or oligosaccharide residues at different concentrations for...
Oral and ocular dryness are frequent serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process the secretory pathway, requires participation Rab family GTPases. This study was undertaken analyze expression localization Rab3D Rab8A examine their correlation with acinar cell polarity function.Nineteen patients SS 17 controls were evaluated. Levels messenger RNA (mRNA) protein determined by real-time polymerase...
Xerostomia in SS patients has been associated with low quality and quantity of salivary mucins, which are fundamental for the hydration protection oral mucosa. The aim this study was to evaluate if cytokines induce aberrant mucin expression whether tauroursodeoxycholic acid (TUDCA) is able counteract such an anomaly.Labial glands from 16 15 control subjects, as well 3D acini or human submandibular gland cells stimulated TNF-α IFN-γ co-incubated TUDCA, were analysed. mRNA protein levels Mucin...
Sjögren’s syndrome (SS) is an autoimmune disease that mainly affects salivary glands (SG) and characterized by overactivation of the type I interferon (IFN) pathway. Type IFNs can decrease levels hsa-miR-145-5p, a miRNA with anti-inflammatory roles downregulated in SG from SS-patients. Two relevant targets mucin 1 (MUC1) toll-like receptor 4 (TLR4) are overexpressed SS-patients contribute to inflammation dysfunction. This study aimed evaluate if hsa-miR-145-5p modulates MUC1 TLR4...
A calcifying odontogenic cyst (COC) is a cystic lesion originating from epithelium, exhibiting ameloblastomatous features and containing focal accumulations of ghost cells. The standard treatment for COC typically involves enucleation followed by surgical curettage. However, if the large or closely associated with anatomical structures, decompression may be considered as preliminary step before enucleation. 12‐year‐old male patient presented swelling in anterior mandibular region....
Background & Aims: Obesity is associated with an increased risk of atherosclerosis, though recent evidence shows conflicting results. This study aimed to evaluate whether obesity or its metabolic abnormalities play a more significant role in atherosclerosis development primary care population. Methods: A cross-sectional using data from the Cardiometabolic Risk Factor Registry (CARFARE) at Hospital Universitario Austral included adults undergoing their first healthcare visit for...
Neonatal hindpaw incision can evoke long-lasting changes in nociceptive processing following repeat injury adulthood. Studies have focused on the effects and mechanisms spinal cord brain, however inflammation macrophages periphery, especially at site of early life injury, remain poorly defined. In this paper, we investigated role injured tissue pain hypersensitivity caused by incisions primed neonatal injury. Hindpaw was performed anesthetized adult rats. Among them, some had postnatal day...
The increase in the incidence of dengue cases region has led to identification multiple complications associated with disease. present study presents case an adolescent girl severe a hyperinflammatory state, who presented mild acute pancreatitis. This complication, although infrequent, can be harmful. In clinical presented, patient dengue, according diagnosis. addition, polyserositis was observed, positive NS1, IgG, and IgM, elevated transaminases above 1000 U/L levels inflammatory markers...
Labial salivary glands (LSGs) of SS patients show alterations related to endoplasmic reticulum stress. Glandular dysfunction could be partly the consequence an altered inositol-requiring enzyme 1α (IRE1α)/X box-binding protein 1 (XBP-1) signalling pathway unfolded response, which then regulates genes involved in biogenesis secretory machinery. This study aimed determine expression, promoter methylation and localization IRE1α/XBP-1 components LSGs also their expression induced by IFN-γ...
MicroRNAs (miRNAs) are small non-coding RNAs (sRNA), that alter gene expression by binding to target messenger (mRNAs) and repressing translation. Dysregulated miRNA has been implicated in the pathogenesis of autoimmune diseases such as Sjögren’s syndrome (SS). The aim this study was characterize global profile sRNAs labial salivary glands (LSG) from SS-patients validate potential candidates glandular inflammation. LSG 21 9 sicca controls were analyzed. A next generation sequencing...