A5073278152- Cerebral Venous Sinus Thrombosis
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Neurosurgical Procedures and Complications
- Migraine and Headache Studies
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Complications and Syndromes
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Eye Disorders
- Hormonal Regulation and Hypertension
- Cerebrospinal fluid and hydrocephalus
- Trigeminal Neuralgia and Treatments
- Retinal Diseases and Treatments
- Diabetes Management and Education
- Retinal and Optic Conditions
- Chronic Disease Management Strategies
- Aldose Reductase and Taurine
- Sympathectomy and Hyperhidrosis Treatments
- Ocular Diseases and Behçet’s Syndrome
- Acute Ischemic Stroke Management
- Systemic Lupus Erythematosus Research
- Diet and metabolism studies
- Frailty in Older Adults
- Pregnancy and preeclampsia studies
University of Birmingham
2016-2025
University Hospitals Birmingham NHS Foundation Trust
2016-2025
Queen Elizabeth Hospital Birmingham
2016-2025
Queen Elizabeth Hospital
2007-2025
University College London
2023-2025
University College London Hospitals NHS Foundation Trust
2025
Juvenile Diabetes Research Foundation
2024
King's College London
2024
NIHR Surgical Reconstruction and Microbiology Research Centre
2019-2023
ORCID
2023
<h3>Abstract</h3> Nuclei within cells are constantly subjected to compressive, tensile and shear forces, which regulate nucleoskeletal cytoskeletal remodeling, activate signaling pathways direct cell-fate decisions. Multiple rheological methods have been adapted for characterizing the response applied forces of isolated nuclei intact cells. However, <i>in vitro</i> measurements fail capture viscoelastic modulation nuclear stress-strain relationships by physiological tethering surrounding...
Summary Loss of microbial diversity is considered a major threat because its importance for ecosystem functions, but there lack conclusive evidence that itself reduced under anthropogenic stress, and about the consequences loss. Heavy metals are one largest, widespread pollutant types globally, these represent significant environmental stressor terrestrial communities. Using combined metagenomics functional assays, we show compositional response communities to long‐term heavy metal stress...
Despite advances in the management of headache disorders, some patients with migraine do not experience adequate pain relief acute and preventive treatments. It is aim present document to provide a definition those migraines which are difficult-to-treat, create awareness existence this group patients, help Healthcare Authorities understanding implications, basis develop better pathophysiological support further therapeutic advances.Definitions were established consensus process using Delphi...
To quantify the hospital burden and health economic impact of idiopathic intracranial hypertension.Hospital Episode Statistics (HES) national data was extracted between 1st January 2002 31st December 2016. All those within England with a diagnosis hypertension were included. Those secondary causes raised pressure such as tumours, hydrocephalus cerebral venous sinus thrombosis excluded.A total 23,182 new IIH cases diagnosed. Fifty-two percent resided in most socially deprived areas (quintiles...
<h3>Importance</h3> Idiopathic intracranial hypertension (IIH) causes headaches, vision loss, and reduced quality of life. Sustained weight loss among patients with IIH is necessary to modify the disease prevent relapse. <h3>Objective</h3> To compare effectiveness bariatric surgery that a community management (CWM) intervention for treatment active IIH. <h3>Design, Setting, Participants</h3> This 5-year randomized clinical trial (Idiopathic Intracranial Hypertension Weight Trial) enrolled...
Abstract Therapeutics to reduce intracranial pressure are an unmet need. Preclinical data have demonstrated a novel strategy lower using glucagon-like peptide-1 (GLP-1) receptor signalling. Here, we translate these findings into patients by conducting randomized, placebo-controlled, double-blind trial assess the effect of exenatide, GLP-1 agonist, on in idiopathic hypertension. Telemetric catheters enabled long-term monitoring. The enrolled adult women with active hypertension (intracranial...
Idiopathic Intracranial Hypertension (IIH) is characterized by an elevation of intracranial pressure (ICP no identifiable cause. The aetiology remains largely unknown, however observations made in a number recent clinical studies are increasing the understanding disease and now provide basis for evidence-based treatment strategies. Embase, CDSR, CENTRAL, DARE MEDLINE databases were searched up to 1st June 2018. We analyzed randomized controlled trials systematic reviews that investigate IIH....
GLP-1R agonists show promise as a therapeutic agent to lower intracranial pressure in rodents.
Cardiovascular disease (CVD) risk has not been previously evaluated in a large matched cohort study idiopathic intracranial hypertension (IIH).
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, characterized by elevated pressure frequently manifesting with chronic headaches and visual loss. Similar to polycystic ovary syndrome (PCOS), IIH predominantly affects obese women reproductive age. In this study, we comprehensively examined the systemic cerebrospinal fluid (CSF) androgen metabolome in comparison sex-, BMI-, age-matched control groups either simple obesity or PCOS (i.e., excess). Women showed...