A5050176788- RNA and protein synthesis mechanisms
- Genomics and Chromatin Dynamics
- CRISPR and Genetic Engineering
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Nuclear Structure and Function
- Microtubule and mitosis dynamics
- Protein Tyrosine Phosphatases
- Advanced biosensing and bioanalysis techniques
- FOXO transcription factor regulation
- Genetically Modified Organisms Research
- Melanoma and MAPK Pathways
- Fungal and yeast genetics research
- Cancer Mechanisms and Therapy
- Ubiquitin and proteasome pathways
- Protein Structure and Dynamics
- Genomic variations and chromosomal abnormalities
- Genomics and Phylogenetic Studies
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Microbial Community Ecology and Physiology
- DNA Repair Mechanisms
- Bacterial Genetics and Biotechnology
- BRCA gene mutations in cancer
Shaker Heights Public Library
2009-2011
Case Western Reserve University
2006-2007
Taipei Institute of Pathology
2005
Myriad Genetics
1995-1997
Oxidative modification of cytoplasmic RNA in vulnerable neurons is an important, well documented feature the pathophysiology Alzheimer disease. Here we report that RNA-bound iron plays a pivotal role for oxidation disease brain. The cytoplasm hippocampal showed significantly higher redox activity and iron(II) staining than age-matched controls. Notably, both were susceptible to RNase, suggesting physical association with RNA. Ultrastructural analysis further suggested endoplasmic reticulum...
Caspase-dependent apoptotic cell death has been extensively studied in cultured cells and during embryonic development, but the existence of analogous molecular pathways single-cell species is uncertain. This reduced enthusiasm for applying advanced genetic tools available yeast to study regulation. However, partial characterization mammals additional genetically encoded mechanisms, which lead a range dying morphologies necrosis, suggests potential applications genetics. In this light, we...
Insulin-signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to structural reorganization. To test functional coupling between insulin's "hinge opening" activation, we inserted an artificial ligand-dependent switch into insulin molecule. Ligand-binding disrupts internal tether designed stabilize hormone's native closed inactive conformation, thereby enabling productive engagement. This scheme exploited...
Abstract Background Since S. cerevisiae undergoes closed mitosis, the nuclear envelope of daughter nucleus is continuous with that maternal at anaphase. Nevertheless, several constitutents are not present in nucleus. The study aims to identify proteins which impact shape yeast and learn whether modifications passed on next mitotic generation. Esc1p protein localizes periphery nucleoplasm, can anchor chromatin, has been implicated targeted silencing both telomeres HMR. Results Upon increased...
An integrated approach involving physical mapping, identification of transcribed sequences, and computational analysis genomic sequence was used to generate a detailed transcription map the 1.0-Mb region containing breast cancer susceptibility locusBRCA2on chromosome 13q12–q13. This is included in genetic interval bounded byD13S1444andD13S310.Retrieved sequences from exon amplification or hybrid selection procedures were grouped into intervals subsequently units by clone overlap. Overlap...
Abstract Insulin signaling requires conformational change: whereas the free hormone and its receptor each adopt autoinhibited conformations, their binding leads to large-scale structural reorganization. To test coupling between insulin’s “opening” activation, we inserted an artificial ligand-dependent switch into insulin. Ligand disrupts internal tether designed stabilize hormone’s native closed inactive conformation, thereby enabling productive engagement. This scheme exploited a diol...