A5034502482- Spectroscopy Techniques in Biomedical and Chemical Research
- Spectroscopy and Chemometric Analyses
- Biosensors and Analytical Detection
- Bacterial Identification and Susceptibility Testing
- Listeria monocytogenes in Food Safety
- Metabolomics and Mass Spectrometry Studies
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- Optical Coherence Tomography Applications
- Optical Imaging and Spectroscopy Techniques
- Digital Imaging for Blood Diseases
- Advanced Chemical Sensor Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
- Cell Image Analysis Techniques
- Advanced Fluorescence Microscopy Techniques
- Image Processing Techniques and Applications
- Identification and Quantification in Food
- Microfluidic and Capillary Electrophoresis Applications
- Water Quality Monitoring and Analysis
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mineral Processing and Grinding
- Bee Products Chemical Analysis
- Bladder and Urothelial Cancer Treatments
- Bacillus and Francisella bacterial research
- Radiomics and Machine Learning in Medical Imaging
Helmholtz Institute Jena
2016-2025
Friedrich Schiller University Jena
2016-2025
Leibniz Institute of Photonic Technology
2016-2025
Schiller International University
2014-2025
University of Bayreuth
2023-2024
InfectoGnostics Research Campus Jena
2014-2023
Czech Academy of Sciences, Institute of Computer Science
2023
Applied Research Associates
2021
Institute of Physical Chemistry
2017-2020
Technologies pour la Santé
2020
Significance Measuring activity patterns of microbes in their natural environment is essential for understanding ecosystems and the multifaceted interactions microorganisms with eukaryotes. In this study, we developed a technique that allows fast nondestructive measurements microbial communities on single-cell level. Microbial were amended heavy water (D 2 O), treatment does not change available substrate pool. After incubation, physiologically active cells are rapidly identified Raman...
Raman spectroscopy has been recognized to be a powerful tool for label-free discrimination of cells. Sampling methods are under development utilize the unique capabilities identify cells in body fluids such as saliva, urine or blood. The current study applied optical traps combination with acquire spectra single microfluidic glass channels. Optical were realized by two 1070 nm mode fibre lasers. Microflows controlled syringe pump system. A novel chip was designed inject cells, modify flow...
Medical diagnosis can be improved significantly by fast, highly sensitive and quantitative cell identification from easily accessible body fluids. Prominent examples are disseminated tumor cells circulating in the peripheral blood of cancer patients. These extremely rare therefore difficult to detect. In this contribution we present Raman spectroscopic characterization different that found such as leukocytes, leukemic solid cells. Leukocytes were isolated healthy donors. Breast carcinoma...
The first response to infection in the blood is mediated by leukocytes. As a result crucial information can be gained from hemogram. Conventional methods such as smears and automated sorting procedures are not capable of recording detailed biochemical different In this study, Raman spectroscopy has been applied investigate differences between leukocyte subtypes which have obtained healthy donors. imaging was able visualize same morphological features standard staining without need any label....
A closed droplet based lab-on-a-chip (LOC) device has been developed for the differentiation of six species mycobacteria, i.e., both Mycobacterium tuberculosis complex (MTC) and nontuberculous mycobacteria (NTM), using surface-enhanced Raman spectroscopy (SERS). The combination a fast simple bead-beating module disruption bacterial cell with LOC-SERS enables application an easy reliable system bacteria discrimination. Without extraction or further treatment sample, obtained SERS spectra are...
The common mistakes of cross-validation (CV) for the development chemometric models Raman based biological applications were investigated.
ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTRaman Spectroscopy and Imaging in BioanalyticsDana Cialla-MayDana Cialla-MayLeibniz-Institute of Photonic Technology, Member the Leibniz Research Alliance − Health Technologies, Albert-Einstein-Str. 9, 07745 Jena, GermanyInstitute Physical Chemistry Abbe Center Photonics, Friedrich Schiller University, Helmholtzweg 4, 07743 GermanyInfectoGnostics Campus Applied Research, Philosophenweg 7, GermanyMore by Dana Cialla-MayView Biography, Christoph...
Body fluids are easily accessible and contain valuable indices for medical diagnosis. Fascinating tools tumour cells circulating in the peripheral blood of cancer patients. As these extremely rare, they constitute a challenge clinical diagnostics. In this contribution we present Raman spectroscopic-based identification different single suspension that found patients including healthy like leukocytes erythrocytes, leukaemic originating from solid tumours. Leukocytes erythrocytes were isolated...
In the last decade Raman-spectroscopy has become an invaluable tool for biomedical diagnostics. However, a manual rating of subtle spectral differences between normal and abnormal disease states is not possible or practical. Thus it necessary to combine with chemometrics in order build statistical models predicting directly without intervention. Within chemometrical analysis number corrections have be applied receive robust models. Baseline correction important step pre-processing, which...
Experimental evidence of extremely high spatial resolution tip-enhanced Raman scattering (TERS) has been recently demonstrated. Here, we present a full quantum chemical description (at the density functional level theory) non-resonant effects on spectrum an adenine molecule mapped by tip, modeled as single silver atom or small cluster. We show pronounced changes in pattern and its intensities depending conformation nanoparticle-substrate system, concluding that contribution TERS can be sub-nm range.
Due to the steadily increasing number of cancer patients worldwide early diagnosis and treatment is a major field research. The mostly performed by an experienced pathologist via visual inspection histo-pathological stained tissue sections. To save valuable time, low quality cryosections are frequently analyzed with diagnostic accuracies that below those high embedded Thus, alternative means have be found enable for fast accurate as basis following clinical decision making. In this...
The emergence of antibacterial resistance and the development new drugs lead to a continuous change guidelines for medical treatments. Hence, analytical tools are required detection in biological fluids. In this study, first surface enhanced Raman scattering (SERS) nitroxoline (NTX) purified water spiked human urine samples is reported. Insights concerning nature molecule-metal interaction its influence on overall SERS signal provided. Furthermore, three randomly collected originating from...