A5069579443- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- S100 Proteins and Annexins
- Neurological and metabolic disorders
- Medical and Biological Sciences
- Computational Drug Discovery Methods
- Neurological Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Geriatric Care and Nursing Homes
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurological disorders and treatments
- Nutritional Studies and Diet
- Blood Coagulation and Thrombosis Mechanisms
- Fractal and DNA sequence analysis
- Folate and B Vitamins Research
- Cancer Research and Treatment
- Electroconvulsive Therapy Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Advanced Neuroimaging Techniques and Applications
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Health and Medical Education
Sunagawa City Medical Center
2013-2024
Sapporo Medical University
1995-2002
Background and Purpose Dementia with Lewy bodies (DLB) needs to be distinguished from Alzheimer’s disease (AD) because of important differences in patient management outcome. Severe cardiac sympathetic degeneration occurs DLB, but not AD, offering a potential system for biological diagnostic marker. The primary aim this study was investigate the accuracy, ante-mortem differentiation probable DLB imaging ligand 123I-meta-iodobenzylguanidine (MIBG) which binds noradrenaline reuptake site,...
Background and purpose We previously reported the usefulness of iodine-123 metaiodobenzylguanidine ( 123 I-MIBG) myocardial scintigraphy for differentiation dementia with Lewy bodies (DLB) from Alzheimer’s disease (AD) in a cross-sectional multicentre study. The aim this study was, by using reassessed diagnosis after 3-year follow-up, to evaluate diagnostic accuracy I-MIBG probable DLB AD. Methods undertook follow-up 133 patients or possible AD who had undergone at baseline. An independent...
Aim Although dementia with Lewy bodies (DLB) is characterized by a variety of initial symptoms, there are almost no reports the symptoms DLB assessed in large number cases. We retrospectively evaluated 234 participants and DLB‐related at diagnosis any gender differences symptom profiles. Methods This study consisted probable who met diagnostic criteria outlined Fourth Consensus Report Consortium (2017). was confirmed based on several characteristic biomarkers for dopamine transporter imaging...
Nutritional epidemiology has shown that inadequate dietary protein intake is associated with poor brain function in the elderly population. The plasma free amino acid (PFAA) profile reflects nutritional status and may have potential to predict future changes cognitive function. Here, we report results of a 2-year interim analysis 3-year longitudinal study following mild impairment (MCI) participants.In multicenter prospective cohort design, MCI participants were recruited, fasting samples...
Many cases of dementia with Lewy bodies (DLB) present various psychotic features, including hallucinations, depression, catatonia, and delusions before the onset cognitive impairment. However, characteristic features these symptoms in prodromal DLB have not been sufficiently described.To clarify describe overt impairment.The authors analyzed 21 subjects who developed severe without were diagnosed as after longitudinal observation period. They then confirmed to through indicative supportive...
Background The apolipoprotein E (APOE) ε4 allele has been reported to be a risk factor for Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Previous neuropathological studies have demonstrated similar frequencies of the APOE in AD DLB. However, few ante-mortem on DLB shown lower than post-mortem studies. One reason this may inaccuracy diagnosis. We examined genotypes subjects AD, DLB, control group using latest diagnostic criteria MRI, SPECT, MIBG myocardial scintigraphy....
Alzheimer's disease (AD) differs from other forms of dementia in its relation to amyloid beta peptide (Aβ42). Using a cell culture model we previously identified annexin A5, Ca(2+), and phospholipid binding protein, as an AD biomarker. Plasma level A5 was significantly higher patients compared that control group. On the hand, has been share number clinical pathological features with Dementia Lewy bodies (DLB). The present study done examine whether or not plasma is specific marker for AD,...
<i>Background:</i> Supportive features in the diagnostic criteria for dementia with Lewy bodies (DLB) include occipital hypoperfusion and decreased cardiac uptake of <sup>123</sup>I-metaiodobenzylguanidine (MIBG). In this study, we performed both brain perfusion single photon emission computed tomography (SPECT) MIBG myocardial scintigraphy same subjects evaluated their sensitivity to detect characteristic DLB. <i>Methods:</i> Twenty-five patients probable...
Alzheimer's disease (AD) differs from other forms of dementia in its relation to amyloid beta peptide (Abeta). Abeta, a proteolytic product precursor proteins (APP), has toxic effect on neuronal cells, which involves perturbation their Ca(2+) homeostasis. This implies that changes protein expression cells with calcium stress should provide molecular marker for this disease. In the present study, we used supernatant cell culture after incubation or without Abeta and isolated Ca(2+)-dependent...
Aim People living with early‐onset dementia (EOD) have specific social needs. Epidemiological studies are needed to obtain current information and provide appropriate service planning. This study aimed clarify the prevalence subtype distribution of EOD, as well services frequently used by individuals EOD. Methods A multisite, population‐based, two‐step was conducted. Questionnaires were sent 26 416 candidate facilities in 12 areas a target population 11 630 322 inquire whether any EOD had...
<i>Background/Aims:</i> It is often difficult to distinguish idiopathic normal pressure hydrocephalus (iNPH) from other neurodegenerative disorders such as Alzheimer’s disease (AD). To understand the characteristic pattern of blood flow in iNPH, we performed brain perfusion SPECT and analyzed results by using easy Z-score imaging system (eZIS). <i>Methods:</i> Subjects were 12 patients with probable iNPH 10 AD prominent ventriculomegaly. They underwent...
Background Current diagnostic criteria recommend neuroimaging as a support tool for the clinical diagnosis of dementia with Lewy bodies (DLB). Because DLB causes characteristic impairments and disabilities, such neuroleptic hypersensitivity, which may significantly increase morbidity mortality, its prompt correct is very important. The aim this study was to evaluate extent accuracy can be increased by using different combinations brain perfusion single‐photon emission computed tomography...
Nutritional epidemiology has shown the importance of protein intake for maintaining brain function in elderly population. Mild cognitive impairment (MCI) may be associated with malnutrition, especially intake. We explored blood-based biomarkers linking nutritional status MCI a multicenter study. In total, 219 individuals (79.5 ± 5.7 year) from 10 institutions and 220 who were cognitively normal (CN, 76.3 6.6 four different cities Japan recruited. They divided into training (120 120 CN)...
Because dementia with Lewy bodies (DLB) has various psychiatric symptoms, early diagnosis in patients without parkinsonism is difficult. To reveal associations between regional brain perfusion and symptoms DLB parkinsonism, we quantified using an automated single-photon emission computed tomography analysis program, FineSRT. We statistically analyzed the differences groups, divided by presence or absence of symptoms. In depression, there were significant increases left angular gyrus right...
In addition to motor symptoms, patients with Parkinson disease (PD) experience various psychiatric comorbidities, including impulse control disorders (ICDs). Moreover, antiparkinsonian drugs sometimes cause symptoms. Antiparkinsonian and antipsychotic are competitive in pharmacodynamics, psychotropic drugs, antidepressants, may worsen symptoms or induce adverse reactions. Considering this conflicting situation, we examined the effectiveness of electroconvulsive therapy (ECT) on both PD.We...
The aim of this study was to investigate initial symptoms early-onset dementia (EOD) for each subtype.We conducted a nationwide, population-based EOD prevalence in Japan. Data were collected through service providers people with EOD. Initial assessed six domains: loss memory, difficulty word generation, irritability, motivation, increased mistakes the workplace or domestically, and unusual behaviours attitudes other than those listed.Participants 770 Characteristic observed subtype. Loss...