A5033688509- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Advanced Optical Sensing Technologies
- 3D IC and TSV technologies
- Superconducting Materials and Applications
- Electronic Packaging and Soldering Technologies
- Bioinformatics and Genomic Networks
- Laser-Plasma Interactions and Diagnostics
- Advanced X-ray Imaging Techniques
- Cardiovascular Function and Risk Factors
- DNA and Nucleic Acid Chemistry
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Gyrotron and Vacuum Electronics Research
- Cardiac Fibrosis and Remodeling
- Photonic and Optical Devices
- Advanced biosensing and bioanalysis techniques
- Cardiovascular Disease and Adiposity
- Advanced X-ray and CT Imaging
- Magnetic confinement fusion research
- Nuclear Physics and Applications
- Electromagnetic Compatibility and Noise Suppression
- Adipose Tissue and Metabolism
- Laser Design and Applications
- Single-cell and spatial transcriptomics
Baker Heart and Diabetes Institute
2021-2025
University of Oxford
2024
Melbourne Clinic
2024
MediaTek (Taiwan)
2012-2023
National Tsing Hua University
2010-2020
Columbia University
2020
Johns Hopkins University
2011-2012
Johns Hopkins Medicine
2011
National Synchrotron Radiation Research Center
1995-2003
University of Wisconsin–Madison
2003
Background: Aortic stiffening is a consequence of hypertension and major contributor to end organ damage. A key driver aortic fibrosis involving the excess production extracellular matrix (ECM) proteins such as collagen, fibronectin laminin. The present study aimed identify cell types signalling mechanisms that contribute in hypertension. Methods Results: Male C57BL/6 mice (10-12-week-old) were randomly assigned 28-day angiotensin II (0.7 mg/kg/day) or vehicle (saline) infusion via osmotic...
In daily life, humans are exposed to the extremely low-frequency electromagnetic fields (ELF-EMFs) generated by electric appliances, and public concern is increasing regarding biological effects of such exposure. Numerous studies have yielded inconsistent results ELF-EMF Here we show that ELF-EMFs activate ATM-Chk2-p21 pathway in HaCaT cells, inhibiting cell proliferation. To present well-founded results, comprehensively evaluated at transcriptional, protein, cellular levels. Human cells...
Coronary microvascular dysfunction (CMD) is associated with cardiac and predictive of mortality in obesity, especially females. Clinical data further support that CMD associates development heart failure preserved ejection fraction mineralocorticoid receptor (MR) antagonism may be more efficacious obese female, versus male, HFpEF patients. Accordingly, we examined the impact smooth muscle cell (SMC)-specific MR deletion on obesity-associated coronary diastolic female mice. Obesity was...
Abstract Honokiol (HNK) is a phenolic compound isolated from the bark of houpu ( Magnolia officinalis ), plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti‐inflammatory activity, its effect on dendritic cells (DCs) during inflammatory reaction remains unclear. The present study investigates how affects lipopolysaccharide (LPS)‐stimulated human monocyte‐derived DCs. Our experimental results show inhibits response...
Over the past decade, gene expression microarray studies have greatly expanded our knowledge of genetic mechanisms human diseases. Meta-analysis substantial amounts accumulated data, by integrating valuable information from multiple studies, is becoming more important in research. However, collecting data special interest public repositories often present major practical problems. Moreover, including low-quality may significantly reduce meta-analysis efficiency.M2DB a curated database...
<title>Abstract</title> CD14 is a widely validated marker for monocyte/macrophage activity as well an inflammatory biomarker and upstream regulator of macrophage activity. We herein test the hypothesis that interventional blockade with murine analogue atibuclimab, anti-CD14 antibody, which has recently been reported to have favorable safety profile, prevents secondary immunological exacerbation cardiac injury in translational mouse model reperfused ST-elevation myocardial infarction (STEMI)...
Cordyceps sinensis (CS), a Chinese tonifying herb, has been widely used for centuries in Asian countries as medicine and health supplement. Although ample evidence indicates that CS can modulate immune responses, the functional effect of on dendritic cells (DCs) is still unclear. This study examines how affects human monocyte-derived DCs two physiological states: naïve LPS-induced inflammatory. Our experimental results demonstrate acts an activator maturation inducer immature by stimulating...
Background Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few have addressed influence estimating variance. Methodology/Principal Findings To break intra- and inter-individual variance clinical down to three levels–technical, anatomic, individual–we designed experiments algorithms investigate forms variances. As case study, group "inter-individual variable genes" were identified exemplify...
DNA samples are commonly frozen for storage. However, freezing can compromise the integrity of molecules. Considering wide applications molecules in nanotechnology, changes to at molecular level may cause undesirable outcomes. effects on have not been fully explored. To investigate impact integrity, and non-frozen bacteriophage lambda were studied using optical tweezers. Tension (5–35 pN) was applied mimic mechanical interactions between other biomolecules. The evaluated by measuring time...
Laser Compton scattering by relativistic electrons provides the energy information associated with electron beams in an accelerator. Determining beam this method depends primarily on signal to noise (S/N) ratio laser scattering. In study, we propose a enhance S/N synchronous measurement high peak power pulsed ${\mathrm{CO}}_{2}$ laser. method, gate trigger signals, and delay times of triggers are optimized obtain maximum ratio. storage ring Taiwan Light Source, \ensuremath{\gamma} ray...
Abstract In this study, science faculty and educators collaboratively developed a plan to evaluate an interdisciplinary curriculum its administration policy. The were engaged in determining criteria for evaluation interpreting data. collaborative stressed graduate attributes the affective domain provided dynamic revision. Four cohorts of students voluntarily completed scales that measured their attitudes toward course-taking patterns, career choice. results suggested students' involvement...
Tsai, M-L., Chang, K-Y., Chiang, C-S., Shu, W-Y., Weng, T-C., Chen, C. R., Huang, C-L., Lin, H-K. and Hsu, I. UVB Radiation Induces Persistent Activation of Ribosome Oxidative Phosphorylation Pathways. Radiat. Res. 171, 716–724 (2009).Ultraviolet B (UVB) radiation has strong biological effects modulates the expression many genes. The major pathways affected by remain controversial. In this work, we used a loop-design microarray approach applied rigorous statistical analyses to identify...
Following an increase in the use of electric appliances that can generate 50 or 60 Hz electromagnetic fields, concerns have intensified regarding biological effects extremely low-frequency fields (ELF-EMFs) on human health. Previous epidemiological studies suggested carcinogenic potential environmental exposure to ELF-EMFs, specifically at Hz. However, mechanism facilitating ELF-EMFs remains unclear. Cellular yielded inconsistent results ELF-EMFs. The might been due diverse cell types. In...
2.5D silicon interposer packages have been widely adopted for high-end applications such as datacenter, networking, and artificial intelligence. To meet the increasing demand higher performance greater bandwidth, die package sizes due to need levels of device integration. As size increases, chip-to-package interaction (CPI) will become more challenging manage. The main challenges with large 2.5 devices are warpage, C4 bump integrity, underfill cracking, mold compound delamination caused by...