A5001792311- Drug Solubulity and Delivery Systems
- Essential Oils and Antimicrobial Activity
- Polysaccharides Composition and Applications
- Ethnobotanical and Medicinal Plants Studies
- Piperaceae Chemical and Biological Studies
- Moringa oleifera research and applications
- Ginger and Zingiberaceae research
- Phytochemistry and Biological Activities
- Advanced Drug Delivery Systems
- Gastrointestinal motility and disorders
- Chemical synthesis and alkaloids
- Topic Modeling
- Biological Control of Invasive Species
- Natural product bioactivities and synthesis
- Bee Products Chemical Analysis
- Safe Handling of Antineoplastic Drugs
- Biomedical Text Mining and Ontologies
- Botanical Research and Chemistry
- Insect-Plant Interactions and Control
- Marine Sponges and Natural Products
- Lichen and fungal ecology
- Sesquiterpenes and Asteraceae Studies
- Psidium guajava Extracts and Applications
- Aquaculture Nutrition and Growth
- Insect Pest Control Strategies
Georgia Institute of Technology
2025
Emory University
2025
University of Uyo
2009-2015
Alfred Health
2012
Animal and Plant Health Inspection Service
1993
This work introduces TrialSieve, a novel framework for biomedical information extraction that enhances clinical meta-analysis and drug repurposing. By extending traditional PICO (Patient, Intervention, Comparison, Outcome) methodologies, TrialSieve incorporates hierarchical, treatment group-based graphs, enabling more comprehensive quantitative comparisons of outcomes. was used to annotate 1609 PubMed abstracts, 170,557 annotations, 52,638 final spans, incorporating 20 unique annotation...
The in vitro combined effects of Nystatin and methanol extract leaves ofEuphorbia hirta against clinical isolates of Candida albicans were investigated using the Checkerboard technique. The organism was susceptible to with MIC 25 mg/ml, while had 0.165 mg/ml against C. albicans. Upon combination, some ratios showed synergistic others indicated indifferent activities against isolates. These results indicate that combinations nystatin could be in activity for ratio others. Key...
The analgesic activities of the aqueous extract of Carpolobia lutea was evaluated in mice and rats using mouse writhing, tail flick formalin induced pain tests. Analgesic studies were performed three models; writhing assay, test assay. (1500 to 2500 mg/kg) acetylsalicylic acid (100 produced a significant (P<0.05) inhibition second phase model, while antinoceptive effect was not first phase. also showed dose dependent acetic abdominal writhings. latency enhanced by extract. Oral...
The ethanolic leaf extract of Heinsia crinata, grown particularly for the in Niger Delta region Nigeria, was evaluated antiplasmodial activity Plasmodium berghei-infected mice as well hypoglycemic and antidiabetic activities alloxan-induced diabetic rats. H. crinata (450-1,350 mg/kg/day) exhibited significant (P < .05) blood schizonticidal both 4-day early infection test established with a considerable mean survival time, though not comparable to that standard drug, chloroquine (5...
The in vitro combined effects of erythromycin and methanol extract leaves ofEuphorbia hirta against clinical isolates of Staphylococcus aureus were investigated using the Checkerboard technique. The organism was susceptible to with MIC 25 mg/ml, while had 0.005 mg/ml. research aims investigate possible interaction that may exist when standardize herbal drugs are combined synthetic antimicrobials. Previously, stock solutions both were prepared in appropriate volume dimethylsulphoxide water...
The effect of the aqueous root extract Talinum triangulare on gastrointestinal system was evaluated in mice and rats using normal intestinal transit. Castor oil induced diarrhea castor enteropooling models. result obtained showed that, effects were dose dependent biphasic all models used. (500, 1000 2000 mg/kg) produced a significant (p < 0.05) decrease propulsion at mg/kg frequency defecation, severity and, afforded protection from treated with oil. Unlike atropine, significantly inhibited...
Control of rangeland grasshoppers with flaky wheat bran treated diflubenzuron and carbaryl was tested in South Dakota during 1988 1989. Diflubenzuron (0.75 or 1.0% [AI]/kg) delivered at 1.1 2.2 kg/ha (2.0% kg/ha. In 1989, treatments were equally effective. The 2-yr (1988 + 1989) combined total population reductions ranged from 34.9 ± 10.5% for the 0.75% (AI)/kg applied to 66.7 11.0% standard 2.0% AI/kg 57.9 6.0%. variability between applications two sites caused mainly by difference...
Comparative evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol (PCM) granules and tablets was performed using acacia, gelatin, Sodium carboxyl methylcellulose (SCMC) standard binders for comparison. The properties such as; flow rate, angle repose, density, weight uniformity, crushing strength, friability, disintegration rate release profiles, were evaluated. compact had good properties. However, concentration influenced characteristics. SIG gave highest...
Ethylenediamine Tetraacetic Acid (EDTA) is a compound predominantly known for its chelating ability. It has also been found that in combination with antibacterial agents like benzakolium and chlorocresol, they were able to kill resistant bacteria. EDTA was used ciprofloxacin, fluoroquinolone, against Shigella sonnei. This done by determining their respective combined Minimum Inhibitory Concentration (MIC) using obtained MIC obtain fractional inhibitory concentration (F.I.C) order determine...
Journal of Pharmaceutical Research International (ISSN: 2456-9119) is dedicated to publish high quality papers in all areas pharmaceutical Science including drugs, community pharmacy, hospital clinical compounding consultant internet veterinary nuclear military pharmacy informatics, pharmaceutics, medicinal chemistry, pharmacognosy, pharmacotherapy, pharmacodynamics, pharmacokinetics, pharmacology, neuropharmacology, psychopharmacology, pharmacogenetics, pharmacogenomics,...
Six brands of fruit juice preparations made up three different batches per brand were used for the study. The purpose experiment was to identify and characterize microbial load (bioload) in these products using standard procedures. At end study, none samples found contain any viable microorganism. These findings showed that study high quality standard, therefore fit human consumption. Foods with a pH lower than 4 are considered as acid generally regarded not being susceptible spoilage by...
The effect of various preservatives such as Methyl paraben, Propyl benzoic acid and paraben (1:10) on a pectin – base ofloxacin vaginal gel was tested. Five batches pectin-based were assessed by antibiotic sensitive test, determination the minimum inhibitory concentration (MIC) bacterial (MBC) for both active drug preservative using Staphylococcus aureus Escherichia coli test organism. Physical properties colour, texture PH Pectinbased gels also examined. All showed susceptibility according...
<h3>Background</h3> The Baxter VialMate adaptor is a device used in the reconstitution of intravenously administered medicines. It connected directly between medicine phial and small infusion bag resulting closed system with potential advantages associated reducing errors, time required for drug preparation, consumable costs contamination. Evaluation magnitude these benefits to support routine adoption. <h3>Purpose</h3> To investigate: ▶physical compatibility parenteral vials ▶the difference...
The Larvicidal Activity of Methanol extract and fractions Myristica fragrans (Myristicaceae) was evaluated on larvae Anopheles gambiae. seeds were macerated in 100% redistilled n-hexane for 24 hours to the oil, then methanol 72hours, filtered concentrated dryness. crude M. exhibited % mortalities range 30.00 + 0.00 -100+0.00 LC50 0.02 mg/mL. N-hexane fraction equally as active with 25+ 1.00-100+0.00 0.02mg/mL. reference compound Nicotine had %mortality 15.00+ – 100.00+0.00 0.04mg/mL.
This study investigated the antinociceptive effects of methanolic extract stem wood ofMicrodermis puberula (Hook. F. Ex. Planch) in Swiss albino mice either sex with weights ranging from 17 to 25 g. Acetylsalicylic acid and morphine were used as standards for tests while distilled water was control. Acetic - induced mouse writhing reflex test hot plate determine peripheral central pain inhibition respectively, using five groups animals each model. The administered in three dosages: 600,...
Crushed Piper nigrum fruits are used for seasoning and flavouring of food. Some investigators have reported on its efficacy as an aid to the contraction uterus in diet post-partum women. This study aims at investigating effect P. salivary glands 3, 5 7 days administration orally. Adult male female Wistar rats (n = 30) weighing between 150 250 g were randomly assigned into experimental 24) control 6) groups. The groups received a mixed feed consistency crushed rat mash ratio 50:50 (Group A,...