A5101667526- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Pancreatitis Pathology and Treatment
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Colorectal Cancer Screening and Detection
- Hepatitis B Virus Studies
- Colorectal Cancer Surgical Treatments
- Gastrointestinal disorders and treatments
- MRI in cancer diagnosis
- Viral-associated cancers and disorders
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Abdominal vascular conditions and treatments
- Colorectal and Anal Carcinomas
- Cancer Mechanisms and Therapy
Hangzhou Medical College
2017-2025
Zhejiang Provincial People's Hospital
2016-2025
Shanxi Medical University
2024
Wuhan University
2024
Renmin Hospital of Wuhan University
2024
Qinghai University Affiliated Hospital
2013-2023
Qinghai University
2009-2021
Weatherford College
2020
National Natural Science Foundation of China
2020
Eastern Hepatobiliary Surgery Hospital
2020
Abstract Background Angiogenesis and tissue repair in chronic non-healing diabetic wounds remain critical clinical problems. Engineered MSC-derived exosomes have significant potential for the promotion of wound healing. Here, we discuss effects mechanisms eNOS-rich umbilical cord MSC (UCMSC-exo/eNOS) modified by genetic engineering optogenetic techniques on repair. Methods Umbilical mesenchymal stem cells were engineered to express two recombinant proteins. Large amounts eNOS loaded into...
In this paper, we use AdaBoost algorithm as a framework to design new classification algorithm. The combines the characteristics of SVM and algorithms. is used weak classifier cascade multiple classifiers form strong classifier, thus achieving more accurate classification. experiment, paper uses algorithm, carry out several comparison experiments. experimental results show that can achieve higher accuracy in data sets various sizes. At same time, moderate calculation speed, so proposed...
Gallbladder cancer is the most common malignancy of bile duct, with low 5-year survival rate and poor prognosis. Novel effective treatments are urgently needed for therapy this disease. Here, we showed that cordycepin, bioactive compound in genus Cordyceps, induced growth inhibition apoptosis cultured gallbladder cells (Mz-ChA-1, QBC939 GBC-SD lines). We found cordycepin inhibited mTOR complex 1 (mTORC1) activation down-regulated multiple drug resistant (MDR)/hypoxia-inducible factor 1α...
The presence of microvascular invasion (MVI) is a significant malignant pathological feature related to recurrence and survival after liver resection for hepatocellular carcinoma (HCC). This study aimed investigate the relationship between severity in grading MVI long-term oncological outcomes patients with early-stage HCC.A retrospective was conducted on prospectively maintained multicenter database who underwent curative Barcelona Clinic Liver Cancer stage 0/A HCC 2017 2020. Patients were...
Hepatectomy is the preferred treatment for solitary hepatocellular carcinoma (HCC) without macrovascular invasion and distant metastasis, but long-term survival remains unsatisfactory in certain patients. We sought to identify whether grading severity of microscopic vascular (MVI) was associated with recurrence among patients HCC.
Abstract Triple-negative breast cancer (TNBC) is currently the type of with worst prognosis; it lacks specific treatments, such as ER/PR antagonistic endocrine and anti-HER2 targeted therapies. Although immunotherapy immune checkpoints has shown some efficacy in many solid tumors, clinical data TNBC suggest significant limitations. The essence ferroptosis impaired metabolism intracellular lipid oxides, which turn causes activation abnormalities system, including ROS, not only plays an...
In this study, the clinical effectiveness of robot-assisted laparoscopic pancreatico-duodenectomy (RPD) and Total pancreaticoduodenectomy LPD were retrospectively reviewed. From December 2013 to September 2017, 20 patients underwent 80 pancreaticoduodenectomy. The data RPDs first LPDs reviewed retrospectively. There is no difference in operative time, estimated blood loss, length stay, rates complications mortality between RPD group. next 10 cases group had shorter times (p = 0.03) than...
Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and characterized by the co-expression of both CHCC cholangiocyte markers. This study aimed to clarify difference between DPHCC after surgery. Patients with surgery were collected. The clinical characteristics, patterns recurrence, survival outcomes patients compared. Multivariate analyses used determine independent risk factors that influence prognosis patients. (n = 141) account for...
Background Laparoscopic hepatectomy (LH) has achieved rapid progress over the last decade. However, it is still challenging to apply laparoscopy lesions located in segments I, VII, VIII, and IVa hepatic hilar region due difficulty operating around complex anatomical structures. In this study, we applied three-dimensional printing (3DP) indocyanine green (ICG) fluorescence imaging technology laparoscopic (CLH) explore effects value of modified procedure. Materials methods From January 2019...
Abstract Background The Naples Prognostic Score (NPS), integrating inflammatory and nutritional biomarkers, has been reported to be associated with the prognosis of various malignancies, but there is no report on intrahepatic cholangiocarcinoma (ICC). This study aimed explore prognostic value NPS in patients ICC. Methods Patients ICC after hepatectomy were collected, divided into three groups. factors determined by Cox regression analysis. Predictive efficacy was evaluated time-dependent...
Abstract Although robotic radical resection for hilar cholangiocarcinoma (HCCA) has been reported in some large hepatobiliary centers, biliary-enteric reconstruction (BER) remains a critical step that hampers the operation’s success. This study aimed to evaluate feasibility and quality of BER HCCA propose technical recommendations. A retrospective was conducted on patients with who underwent minimally invasive at Zhejiang Provincial People’s Hospital between January 2016 July 2023. 1:2...