A5101636743- Inflammatory mediators and NSAID effects
- NF-κB Signaling Pathways
- Lysosomal Storage Disorders Research
- Cellular transport and secretion
- Trypanosoma species research and implications
- Natural product bioactivities and synthesis
- Algal biology and biofuel production
- Virus-based gene therapy research
- Biological Activity of Diterpenoids and Biflavonoids
- Diatoms and Algae Research
- Helicobacter pylori-related gastroenterology studies
- Autism Spectrum Disorder Research
- Immune Response and Inflammation
- Bioactive natural compounds
- Chemokine receptors and signaling
- Estrogen and related hormone effects
- Bone Metabolism and Diseases
- Bone health and treatments
- Analytical Chemistry and Sensors
Beijing VDJBio (China)
2021
University of Illinois Chicago
2007-2012
Jesse Brown VA Medical Center
2007
Lipid rafts (LRs) are membrane realms characterized by high concentrations of cholesterol and sphingolipids. Often, they portrayed as scaffolds on which many different signaling molecules can assemble their cascades. The idea is garnering significant attention the consequences LR disruption have been shown to be manifest in multiple pathways. In this study, LRs brain twitcher (TWI) mouse, a bona-fide model for infant variants human globoid cell leukodystrophy or Krabbe disease, were...
Abstract This study characterized the therapeutic benefits of combining hematogenous cell replacement with lentiviral‐mediated gene transfer galactosylceramidase (GALC) in Twitcher mice, a bona fide model for Krabbe disease. Bone marrow cells and GALC‐lentiviral vectors were administered intravenously without any preconditioning to newborn pups before postnatal day 2. Treated Twitchers survived up 4 months age. GALC activity remained less than 5% normal values nervous system first 2 after...
Cyclooxygenase (COX)-2 expression and release of prostaglandins (PGs) by macrophages are consistent features lipopolysaccharide (LPS)-induced macrophage inflammation. The two major PGs, PGE2 PGD2, synthesized the prostanoid isomerases, PGE synthases (PGES) PGD (PGDS), respectively. Since profile individual role these isomerases-mediated inflammation in has not been defined, we examined LPS-stimulated PGs production pattern their primary cultured mouse bone marrow derived (BMDM). Our data...
Lysosomal β-galactosylceramidase deficiency results in demyelination and inflammation the nervous system causing neurological Krabbe disease. In Twitcher mouse model of this disease, we found that symptoms parallel progressive severe lymphopenia. Although lymphopoiesis is normal before disease onset, primary secondary lymphoid organs progressively degenerate afterward. This occurs despite preserved erythropoiesis leads to peripheral lymphopenia caused by reduced numbers T cell precursors...
Abstract Selective expression of cyclooxygenase 2 (COX-2) by macrophages could have an important role in the pathobiology inflammation. We reported a functional synergism between PU.1 and other transcription factors that contributes to COX-2 gene macrophages. resides nuclear compartment is activated phosphorylation bind cognate DNA elements containing 5′-GGAA/T-3′ motif, but involved kinase has not been discovered. tested hypothesis NF-κB-inducing (NIK) regulates through inducible PU.1. Our...
The paper aimed to investigate the effect of Pinoresinol diglucoside on differentiation and bone resorption osteoclast RAW264.7, evaluate osteoclasts. In order study differentiation, RANKL was used induce RAW264.7 cells differentiate into osteoclasts, different concentrations added intervene. CCK-8 method applied detect cell viability. TRAP staining employed observe morphology. Annexin V/PI flow cytometry apoptosis. Phalloidin F-actin formation osteoclasts resorption. WB effects...