A5014311489- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Metabolism and Genetic Disorders
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Earthquake and Disaster Impact Studies
- Neurological and metabolic disorders
- Ion channel regulation and function
- Amino Acid Enzymes and Metabolism
- Autoimmune Neurological Disorders and Treatments
- Neuropeptides and Animal Physiology
- Urban and spatial planning
- Botulinum Toxin and Related Neurological Disorders
- Folate and B Vitamins Research
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Neuropathies and Disorders
- Vascular Malformations Diagnosis and Treatment
- Geotechnical Engineering and Soil Stabilization
- Thermochemical Biomass Conversion Processes
- Neurosurgical Procedures and Complications
- Diet and metabolism studies
- Cerebrovascular and Carotid Artery Diseases
- Earthquake and Tsunami Effects
- Intracerebral and Subarachnoid Hemorrhage Research
Tokyo Medical University Hospital
2014-2024
Aizawa Hospital
2015-2024
Tokyo Medical University
2011-2024
Eli Lilly (Japan)
2021
Tomishiro Central Hospital
2021
Shinshu University
2001-2018
Ōtani University
1999-2018
University of Occupational and Environmental Health Japan
2017
Astellas Pharma (Japan)
2017
Mitsubishi Heavy Industries (Japan)
1993-2012
To clarify the mechanism underlying improvement of parkinsonian signs by high-frequency electrical stimulation (HFS) subthalamic nucleus (STN), we investigated effects STN HFS on neuronal activity internal and external segment globus pallidus (GPi GPe, respectively) in two rhesus monkeys rendered administration 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. A scaled-down version chronic stimulating electrode used humans, consisting four metal contacts 0.50 mm length each separated mm, was...
Abstract The effects of posterior internal pallidal ablation (GPi pallidotomy) on parkinsonian signs and symptoms were studied in 15 patients with medically intracally intractable Parkinson's disease(PD). sensorimotor territory the portion globus pallidus adjacent optic tract capsule identified microelectrode recording stimulation. Radiofrequency lesions then created territory. Pallidotomy significantly improved all cardinal motor (tremor, rigidity, akinesia/bradykinesia, gait dysfunction)...
Microelectrode recording was performed in the basal ganglia of 3 patients with generalized dystonia and 1 patient hemiballismus secondary to a brainstem hemorrhage. Neuronal activity recorded from internal external segments globus pallidus assessed for mean discharge rate pattern spontaneous activity. The responses neurons segment passive active movements were also evaluated. Mean rates both pallidum considerably lower than those reported idiopathic Parkinson's disease. In addition, neuronal...
Therapy with human recombinant erythropoietin (EPO) has been accepted as effective for renal anemia in dialysis patients. However, studies rats have shown that correcting EPO may affect the progression of dysfunction. In humans, however, effect on residual function is a matter controversy. We, therefore, investigated whether long-term administration to predialysis patients influences function. Anemic at stage serum creatinine (Cr) concentration ranging from 2 4 (average 2.9) mg/dl and...
Object. The authors describe the microelectrode recording and stimulation techniques used for localizing caudal sensorimotor portion of globus pallidus internus (GPi) nearby structures (internal capsule optic tract) in patients undergoing GPi pallidotomy. Methods. Localization is achieved by developing a topographic map abovementioned based on physiological characteristics neurons basal ganglia microexcitable properties internal tract. location can be determined “form fitting” relevant...
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) or internal segment globus pallidus is a clinically successful treatment for motor symptoms Parkinson's disease. However, mechanisms by which HFS alleviates these are not understood. Whereas initial studies focused on HFS-induced changes in neuronal firing rates, recent suggest that patterns activity may correlate with symptom alleviation. We hypothesized effective STN reduces disorder basal ganglia thalamic circuit,...
<h3>Background:</h3> <i>PLA2G6</i> is the causative gene for infantile neuroaxonal dystrophy, neurodegeneration associated with brain iron accumulation, and Karak syndrome. Based on previous reports, patients mutations could show axonal dystonia, dementia, cerebellar signs. Recently, was also reported as early-onset <i>PARK14</i>-linked dystonia-parkinsonism. <h3>Methods:</h3> To clarify role of mutation in parkinsonism, we conducted analysis 29 selected very (≤30, mean 21.2 ± 8.4 years,...
No prospective study of gamma knife thalamotomy for intractable tremor has previously been reported.To clarify the safety and optimally effective conditions performing unilateral (GK) tremors Parkinson disease (PD) essential (ET), a systematic postirradiation 24-month follow-up was conducted at 6 institutions. We present results this multicenter collaborative trial.In total, 72 patients (PD characterized by tremor, n = 59; ET, 13) were registered Japanese Following our selective procedure,...
Chronic subdural hematoma (CSDH) is generally treated by burr hole irrigation. However, sometimes repeated recurrence observed, and treatment may consequently become difficult. We examined the efficacy of embolization middle meningeal artery (MMA) for such cases.We considered MMA three patients who had refractory CSDH with two were at risk showed signs after surgery. A microcatheter was advanced through as peripherally possible, performed 15-20% n-butyl-2-cyanoacrylate or 200 μm polyvinyl...
Abstract High frequency (>100Hz) electrical stimulation in both the external (GPe) and internal (GPi) segments of globus pallidus was effective improving parkinsonian motor signs. Improvement generally occurred at short latency (<5–10 seconds) GPe GPi but often (50% time) delayed GPi. Dyskinetic movements were observed during within more frequent (20% vs. 9%). These findings suggest that may ameliorate The mechanisms responsible for these observations, however, differ. tendency...
Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an effective tool for treatment of advanced Parkinson's disease. The mechanism by which STN DBS elicits its beneficial effect, however, remains unclear. We previously reported increased rate and produced a more regular periodic pattern neuronal activity internal segment globus pallidus (GPi). Here we extend our observations to neurons pallidal [ventralis lateralis pars oralis (VLo) ventralis anterior (VA)] cerebellar posterior...
Abstract We report on an autopsy findings of a 92‐year‐old male with hemiballism‐hemichorea associated hyperglycemia and striatal hyperintensity T1‐weighed magnetic resonance imaging (MRI), recently described clinicoradiological syndrome. Histologically, the putamen contralateral to hemiballism consisted multiple foci recent infarcts reactive astrocytic interneuronal response. Substrate responsible for MRI signal changes is still inconclusive. © Movement Disorder Society.
Effects of a xenoblotic estrogen, bisphenol A (BPA), on reproductive functions were investigated using adult male rats. BPA was dissolved into sesame oil and injected sc every day (1 mg/rat) for 14 days. Animals killed by decapitation after the final administration BPA, trunk blood, pituitary, testes collected. Plasma concentrations prolactin dramatically Increased pituitary contents slightly increased in group compared to control group. testosterone decreased plasma LH BPA-treated rats...
A family with dystonia associated dyschromatosis symmetrica hereditaria (DSH), mental deterioration, and tissue calcification is described. The proband possessed an adenosine deaminase acting on the RNA 1 gene (ADAR1) mutation Gly1007Arg. This ADAR1 could disturb editing at Q/R sites of glutamate receptor in brain increase Ca(2+) influx into neurons, which thought to induce deterioration. observations our raise possibility that might be a direct cause or predisposing factor for...
A 45-year-old Japanese woman with multiple sclerosis (MS) manifested hypersomnia in a relapse of MS. Magnetic resonance imaging revealed new bilateral hypothalamic lesions, and the hypocretin-1 level cerebrospinal fluid (CSF) was significantly low. Methylprednisolone pulse treatment successfully resolved left lesion, it normalized CSF. These findings suggest that hypocretin (orexin) system may be crucial to maintaining arousal lesions can cause